Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113996889> ?p ?o ?g. }
- W2113996889 endingPage "173" @default.
- W2113996889 startingPage "173" @default.
- W2113996889 abstract "S. aureus is a coloniser and pathogen of humans and mammals. Whole genome sequences of 58 strains of S. aureus in the public domain and data from multi-strain microarrays were compared to assess variation in the sequence of proteins known or putatively interacting with host.These included 24 surface proteins implicated in adhesion (ClfA, ClfB, Cna, Eap, Ebh, EbpS, FnBPA, FnBPB, IsaB, IsdA, IsdB, IsdH, SasB, SasC, SasD, SasF, SasG, SasH, SasK, SdrC, SdrD, SdrE, Spa and SraP) and 13 secreted proteins implicated in immune response evasion (Coa, Ecb, Efb, Emp, EsaC, EsxA, EssC, FLIPr, FLIPr like, Sbi, SCIN-B, SCIN-C, VWbp) located on the stable core genome. Many surface protein genes were missing or truncated, unlike immune evasion genes, and several distinct variants were identified. Domain variants were lineage specific. Unrelated lineages often possess the same sequence variant domains proving that horizontal transfer and recombination has contributed to their evolution. Surprisingly, sequenced strains from four animal S. aureus strains had surface and immune evasion proteins remarkably similar to those found in human strains, yet putative targets of these proteins vary substantially between different hosts. This suggests these proteins are not essential for virulence. However, the most variant protein domains were the putative functional regions and there is biological evidence that variants can be functional, arguing they do play a role.Surface and immune evasion genes are candidates for S. aureus vaccines, and their distribution and functionality is key. Vaccines should contain cocktails of antigens representing all variants or they will not protect against naturally occurring S. aureus populations." @default.
- W2113996889 created "2016-06-24" @default.
- W2113996889 creator A5055004932 @default.
- W2113996889 creator A5060811770 @default.
- W2113996889 date "2010-01-01" @default.
- W2113996889 modified "2023-10-10" @default.
- W2113996889 title "Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions" @default.
- W2113996889 cites W1482645296 @default.
- W2113996889 cites W1483247593 @default.
- W2113996889 cites W1508801011 @default.
- W2113996889 cites W1523347396 @default.
- W2113996889 cites W1546476211 @default.
- W2113996889 cites W1547119536 @default.
- W2113996889 cites W1572955611 @default.
- W2113996889 cites W1598705339 @default.
- W2113996889 cites W1601256941 @default.
- W2113996889 cites W1692166726 @default.
- W2113996889 cites W1908623921 @default.
- W2113996889 cites W1952842430 @default.
- W2113996889 cites W1965096019 @default.
- W2113996889 cites W1965704526 @default.
- W2113996889 cites W1966070420 @default.
- W2113996889 cites W1972138860 @default.
- W2113996889 cites W1975272084 @default.
- W2113996889 cites W1975864079 @default.
- W2113996889 cites W1979135961 @default.
- W2113996889 cites W1981240391 @default.
- W2113996889 cites W1984010753 @default.
- W2113996889 cites W1984346495 @default.
- W2113996889 cites W1988700176 @default.
- W2113996889 cites W1995105203 @default.
- W2113996889 cites W1998930337 @default.
- W2113996889 cites W2002264723 @default.
- W2113996889 cites W2004538785 @default.
- W2113996889 cites W2006571056 @default.
- W2113996889 cites W2007532386 @default.
- W2113996889 cites W2008704953 @default.
- W2113996889 cites W2009161972 @default.
- W2113996889 cites W2012952588 @default.
- W2113996889 cites W2017870685 @default.
- W2113996889 cites W2020012480 @default.
- W2113996889 cites W2022600772 @default.
- W2113996889 cites W2023189620 @default.
- W2113996889 cites W2027756270 @default.
- W2113996889 cites W2030904449 @default.
- W2113996889 cites W2033719139 @default.
- W2113996889 cites W2036114678 @default.
- W2113996889 cites W2037341401 @default.
- W2113996889 cites W2039898194 @default.
- W2113996889 cites W2040823934 @default.
- W2113996889 cites W2042834806 @default.
- W2113996889 cites W2043839045 @default.
- W2113996889 cites W2055664469 @default.
- W2113996889 cites W2060908601 @default.
- W2113996889 cites W2063609296 @default.
- W2113996889 cites W2064713408 @default.
- W2113996889 cites W2071677554 @default.
- W2113996889 cites W2073486093 @default.
- W2113996889 cites W2078335862 @default.
- W2113996889 cites W2078817197 @default.
- W2113996889 cites W2082111828 @default.
- W2113996889 cites W2085212468 @default.
- W2113996889 cites W2087967982 @default.
- W2113996889 cites W2089047063 @default.
- W2113996889 cites W2093388491 @default.
- W2113996889 cites W2093675450 @default.
- W2113996889 cites W2097787501 @default.
- W2113996889 cites W2098624337 @default.
- W2113996889 cites W2099361127 @default.
- W2113996889 cites W2099579829 @default.
- W2113996889 cites W2102074843 @default.
- W2113996889 cites W2104416613 @default.
- W2113996889 cites W2106882534 @default.
- W2113996889 cites W2107250639 @default.
- W2113996889 cites W2107558790 @default.
- W2113996889 cites W2108344826 @default.
- W2113996889 cites W2111113492 @default.
- W2113996889 cites W2111186812 @default.
- W2113996889 cites W2111457654 @default.
- W2113996889 cites W2112328529 @default.
- W2113996889 cites W2112340752 @default.
- W2113996889 cites W2113031999 @default.
- W2113996889 cites W2113651812 @default.
- W2113996889 cites W2115127793 @default.
- W2113996889 cites W2115838347 @default.
- W2113996889 cites W2117337399 @default.
- W2113996889 cites W2118618342 @default.
- W2113996889 cites W2119866231 @default.
- W2113996889 cites W2122710851 @default.
- W2113996889 cites W2123259899 @default.
- W2113996889 cites W2123555654 @default.
- W2113996889 cites W2124749002 @default.
- W2113996889 cites W2127727613 @default.
- W2113996889 cites W2129234516 @default.
- W2113996889 cites W2130176942 @default.
- W2113996889 cites W2133900619 @default.
- W2113996889 cites W2134177745 @default.
- W2113996889 cites W2139009894 @default.