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• W2113997222 startingPage "4458" @default.
• W2113997222 abstract "In populations that are small and asexual, mutations with slight negative effects on fitness will drift to fixation more often than in large or sexual populations in which they will be eliminated by selection. If such mutations occur in substantial numbers, the combined effects of long-term asexuality and small population size may result in substantial accumulation of mildly deleterious substitutions. Prokaryotic endosymbionts of animals that are transmitted maternally for very long periods are effectively asexual and experience smaller effective population size than their free-living relatives. The contrast between such endosymbionts and related free-living bacteria allows us to test whether a population structure imposing frequent bottlenecks and asexuality does lead to an accumulation of slightly deleterious substitutions. Here we show that several independently derived insect endosymbionts, each with a long history of maternal transmission, have accumulated destabilizing base substitutions in the highly conserved 16S rRNA. Stabilities of Domain I of this subunit are 15–25% lower in endosymbionts than in closely related free-living bacteria. By mapping destabilizing substitutions onto a reconstructed phylogeny, we show that decreased ribosomal stability has evolved separately in each endosymbiont lineage. Our phylogenetic approach allows us to demonstrate statistical significance for this pattern: becoming endosymbiotic predictably results in decreased stability of rRNA secondary structure." @default.
• W2113997222 created "2016-06-24" @default.
• W2113997222 creator A5013005155 @default.
• W2113997222 creator A5034815249 @default.
• W2113997222 date "1998-04-14" @default.
• W2113997222 modified "2023-10-16" @default.
• W2113997222 title "Deleterious mutations destabilize ribosomal RNA in endosymbiotic bacteria" @default.
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• W2113997222 doi "https://doi.org/10.1073/pnas.95.8.4458" @default.
• W2113997222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22511" @default.
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