Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113997279> ?p ?o ?g. }
- W2113997279 endingPage "R165" @default.
- W2113997279 startingPage "R157" @default.
- W2113997279 abstract "Changes in body temperature and cell infiltration, mediated by cytokines including tumor necrosis factor-alpha (TNF-alpha), occur during inflammation, but a role of body temperature on inflammatory responses remains obscure. Intraperitoneal injection of 10% casein to mice resulted in transient hypothermia followed by neutrophil accumulation in peritoneal cavities. Peritoneal TNF-alpha was rapidly raised, and pretreatment of mice with an anti-TNF-alpha antibody promoted temperature restoration and partially inhibited neutrophil accumulation. To investigate direct effects of body temperature on neutrophils, peritoneal or peripheral blood neutrophils were cultured at 35 degrees C or 37 degrees C with or without recombinant murine TNF-alpha (100 ng/ml) or a protein synthesis inhibitor cycloheximide (1 microg/ml). Significant inhibition of spontaneous and TNF-alpha-induced apoptosis was obtained at 35 degrees C compared with 37 degrees C, an effect that was not altered by the addition of cycloheximide. Moreover, phagocytic ability of peritoneal neutrophils was significantly enhanced by incubating them at the lower temperature. These results indicate that mild hypothermia induced by endogenous TNF-alpha has enhancing roles on neutrophil survival and function during peritoneal inflammation." @default.
- W2113997279 created "2016-06-24" @default.
- W2113997279 creator A5009514473 @default.
- W2113997279 creator A5009869151 @default.
- W2113997279 creator A5033169316 @default.
- W2113997279 creator A5048501177 @default.
- W2113997279 creator A5052987799 @default.
- W2113997279 creator A5065312521 @default.
- W2113997279 creator A5069455514 @default.
- W2113997279 creator A5081226334 @default.
- W2113997279 creator A5085153622 @default.
- W2113997279 date "2000-01-01" @default.
- W2113997279 modified "2023-10-13" @default.
- W2113997279 title "Role of hypothermia induced by tumor necrosis factor on apoptosis and function of inflammatory neutrophils in mice" @default.
- W2113997279 cites W103399905 @default.
- W2113997279 cites W146301169 @default.
- W2113997279 cites W1485908957 @default.
- W2113997279 cites W1511231027 @default.
- W2113997279 cites W1557233561 @default.
- W2113997279 cites W1582917949 @default.
- W2113997279 cites W1671402482 @default.
- W2113997279 cites W1759927303 @default.
- W2113997279 cites W1843938011 @default.
- W2113997279 cites W1869332987 @default.
- W2113997279 cites W1925319210 @default.
- W2113997279 cites W1951903104 @default.
- W2113997279 cites W1968442371 @default.
- W2113997279 cites W1971816456 @default.
- W2113997279 cites W1979398938 @default.
- W2113997279 cites W1987522424 @default.
- W2113997279 cites W1989845690 @default.
- W2113997279 cites W1992071813 @default.
- W2113997279 cites W1992094377 @default.
- W2113997279 cites W1998961163 @default.
- W2113997279 cites W2024374980 @default.
- W2113997279 cites W2024871040 @default.
- W2113997279 cites W2040207044 @default.
- W2113997279 cites W2045709932 @default.
- W2113997279 cites W2049181771 @default.
- W2113997279 cites W2059628979 @default.
- W2113997279 cites W2071210647 @default.
- W2113997279 cites W2071607561 @default.
- W2113997279 cites W2077405616 @default.
- W2113997279 cites W2091987421 @default.
- W2113997279 cites W2132097733 @default.
- W2113997279 cites W2147434746 @default.
- W2113997279 cites W2156243671 @default.
- W2113997279 cites W2170063404 @default.
- W2113997279 cites W2174163572 @default.
- W2113997279 cites W2203052352 @default.
- W2113997279 cites W2246115909 @default.
- W2113997279 cites W2264168722 @default.
- W2113997279 cites W288673730 @default.
- W2113997279 cites W33406616 @default.
- W2113997279 cites W83442576 @default.
- W2113997279 doi "https://doi.org/10.1152/ajpregu.2000.278.1.r157" @default.
- W2113997279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10644634" @default.
- W2113997279 hasPublicationYear "2000" @default.
- W2113997279 type Work @default.
- W2113997279 sameAs 2113997279 @default.
- W2113997279 citedByCount "12" @default.
- W2113997279 countsByYear W21139972792014 @default.
- W2113997279 crossrefType "journal-article" @default.
- W2113997279 hasAuthorship W2113997279A5009514473 @default.
- W2113997279 hasAuthorship W2113997279A5009869151 @default.
- W2113997279 hasAuthorship W2113997279A5033169316 @default.
- W2113997279 hasAuthorship W2113997279A5048501177 @default.
- W2113997279 hasAuthorship W2113997279A5052987799 @default.
- W2113997279 hasAuthorship W2113997279A5065312521 @default.
- W2113997279 hasAuthorship W2113997279A5069455514 @default.
- W2113997279 hasAuthorship W2113997279A5081226334 @default.
- W2113997279 hasAuthorship W2113997279A5085153622 @default.
- W2113997279 hasConcept C105702510 @default.
- W2113997279 hasConcept C126322002 @default.
- W2113997279 hasConcept C134018914 @default.
- W2113997279 hasConcept C153400128 @default.
- W2113997279 hasConcept C153911025 @default.
- W2113997279 hasConcept C159985019 @default.
- W2113997279 hasConcept C17991360 @default.
- W2113997279 hasConcept C185592680 @default.
- W2113997279 hasConcept C190283241 @default.
- W2113997279 hasConcept C192562407 @default.
- W2113997279 hasConcept C203014093 @default.
- W2113997279 hasConcept C2776914184 @default.
- W2113997279 hasConcept C2777390192 @default.
- W2113997279 hasConcept C2777983669 @default.
- W2113997279 hasConcept C2778128677 @default.
- W2113997279 hasConcept C2778536324 @default.
- W2113997279 hasConcept C2778690821 @default.
- W2113997279 hasConcept C3675279 @default.
- W2113997279 hasConcept C503630168 @default.
- W2113997279 hasConcept C55493867 @default.
- W2113997279 hasConcept C71924100 @default.
- W2113997279 hasConcept C86803240 @default.
- W2113997279 hasConceptScore W2113997279C105702510 @default.
- W2113997279 hasConceptScore W2113997279C126322002 @default.
- W2113997279 hasConceptScore W2113997279C134018914 @default.
- W2113997279 hasConceptScore W2113997279C153400128 @default.