FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114008462> ?p ?o ?g. }

• W2114008462 abstract "Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson’s disease, folding, post-translational modification and recycling of the synaptic protein α-synuclein are clearly altered, leading to a progressive accumulation of pathogenic protein species and the formation of intracellular inclusion bodies. Altered protein folding is one of the first steps of an increasingly understood cascade in which α-synuclein forms complex oligomers and finally distinct protein aggregates, termed Lewy bodies and Lewy neurites. In neurons, an elaborated network of chaperone and co-chaperone proteins is instrumental in mediating protein folding and re-folding. In addition to their direct influence on client proteins, chaperones interact with protein degradation pathways such as the ubiquitin-proteasome-system or autophagy in order to ensure the effective removal of irreversibly misfolded and potentially pathogenic proteins. Because of the vital role of proper protein folding for protein homeostasis, a growing number of studies have evaluated the contribution of chaperone proteins to neurodegeneration. We herein review our current understanding of the involvement of chaperones, co-chaperones and chaperone-mediated autophagy in synucleinopathies with a focus on the Hsp90 and Hsp70 chaperone system. We discuss genetic and pathological studies in Parkinson’s disease as well as experimental studies in models of synucleinopathies that explore molecular chaperones and protein degradation pathways as a novel therapeutic target. To this end, we examine the capacity of chaperones to prevent or modulate neurodegeneration and summarize the current progress in models of Parkinson’s disease and related neurodegenerative disorders." @default.
• W2114008462 created "2016-06-24" @default.
• W2114008462 creator A5010141041 @default.
• W2114008462 creator A5041028445 @default.
• W2114008462 creator A5062627951 @default.
• W2114008462 date "2013-12-01" @default.
• W2114008462 modified "2023-10-14" @default.
• W2114008462 title "Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies" @default.
• W2114008462 cites W101009958 @default.
• W2114008462 cites W12160438 @default.
• W2114008462 cites W1496790952 @default.
• W2114008462 cites W1507128123 @default.
• W2114008462 cites W1515506492 @default.
• W2114008462 cites W1531738304 @default.
• W2114008462 cites W1541950149 @default.
• W2114008462 cites W1573542929 @default.
• W2114008462 cites W1578813045 @default.
• W2114008462 cites W1588992473 @default.
• W2114008462 cites W1590614500 @default.
• W2114008462 cites W1605837172 @default.
• W2114008462 cites W1830116125 @default.
• W2114008462 cites W1965778124 @default.
• W2114008462 cites W1967138582 @default.
• W2114008462 cites W1968303698 @default.
• W2114008462 cites W1968322176 @default.
• W2114008462 cites W1968892625 @default.
• W2114008462 cites W1970085309 @default.
• W2114008462 cites W1971108880 @default.
• W2114008462 cites W1975200549 @default.
• W2114008462 cites W1975279744 @default.
• W2114008462 cites W1976065095 @default.
• W2114008462 cites W1977603207 @default.
• W2114008462 cites W1977977555 @default.
• W2114008462 cites W1978324338 @default.
• W2114008462 cites W1979591162 @default.
• W2114008462 cites W1979915419 @default.
• W2114008462 cites W1986522432 @default.
• W2114008462 cites W1990012982 @default.
• W2114008462 cites W1990232129 @default.
• W2114008462 cites W1990473626 @default.
• W2114008462 cites W1992241406 @default.
• W2114008462 cites W1993467627 @default.
• W2114008462 cites W1995191747 @default.
• W2114008462 cites W1995620782 @default.
• W2114008462 cites W1997524825 @default.
• W2114008462 cites W1997604339 @default.
• W2114008462 cites W1997849090 @default.
• W2114008462 cites W1999049525 @default.
• W2114008462 cites W1999391103 @default.
• W2114008462 cites W2002091021 @default.
• W2114008462 cites W2002410880 @default.
• W2114008462 cites W2002917813 @default.
• W2114008462 cites W2004123088 @default.
• W2114008462 cites W2004758931 @default.
• W2114008462 cites W2005622137 @default.
• W2114008462 cites W2009113642 @default.
• W2114008462 cites W2009556855 @default.
• W2114008462 cites W2010612415 @default.
• W2114008462 cites W2010623074 @default.
• W2114008462 cites W2010648364 @default.
• W2114008462 cites W2011332000 @default.
• W2114008462 cites W2012717721 @default.
• W2114008462 cites W2013429682 @default.
• W2114008462 cites W2013944211 @default.
• W2114008462 cites W2014520750 @default.
• W2114008462 cites W2014749287 @default.
• W2114008462 cites W2015109832 @default.
• W2114008462 cites W2015697740 @default.
• W2114008462 cites W2018633688 @default.
• W2114008462 cites W2021919397 @default.
• W2114008462 cites W2022555554 @default.
• W2114008462 cites W2022964430 @default.
• W2114008462 cites W2024820040 @default.
• W2114008462 cites W2026175550 @default.
• W2114008462 cites W2026717532 @default.
• W2114008462 cites W2027096397 @default.
• W2114008462 cites W2027098023 @default.
• W2114008462 cites W2028955297 @default.
• W2114008462 cites W2030630183 @default.
• W2114008462 cites W2030667534 @default.
• W2114008462 cites W2032817175 @default.
• W2114008462 cites W2033177577 @default.
• W2114008462 cites W2033325995 @default.
• W2114008462 cites W2034723794 @default.
• W2114008462 cites W2034887565 @default.
• W2114008462 cites W2035989121 @default.
• W2114008462 cites W2037262355 @default.
• W2114008462 cites W2038272035 @default.
• W2114008462 cites W2038348009 @default.
• W2114008462 cites W2039425688 @default.
• W2114008462 cites W2039676434 @default.
• W2114008462 cites W2039895875 @default.
• W2114008462 cites W2040042139 @default.
• W2114008462 cites W2041134571 @default.
• W2114008462 cites W2041679645 @default.
• W2114008462 cites W2042018401 @default.
• W2114008462 cites W2042778705 @default.
• W2114008462 cites W2043291430 @default.
• W2114008462 cites W2043428491 @default.
• W2114008462 cites W2044537731 @default.

• next