FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114011696> ?p ?o ?g. }

• W2114011696 endingPage "H82" @default.
• W2114011696 startingPage "H76" @default.
• W2114011696 abstract "Pulmonary hypertension is characterized by increased vascular resistance due to smooth muscle cell hyper-activity and excess deposition of extracellular matrix (ECM) in the vessel wall. We investigated the possibility that changes in cell-ECM interactions may play an active role in this process by modifying the contractile response of pulmonary vascular smooth muscle (PVSM) cells. Contractility was measured within individual cultured PVSM cells, when resting or stimulated with vasoactive agents, by quantitating changes in stiffness of the cytoskeleton (CSK) using magnetic twisting cytometry (N. Wang, J. P. Butler, and D. E. Ingber. Science 260: 1124-1127, 1993). Control studies confirmed that changes in CSK stiffness closely paralleled alterations in cell contraction and relaxation as measured in response to endothelin-1 (ET-1) and dibutyryl guanosine 3',5'-cyclic monophosphate (cGMP), respectively, in a collagen gel contraction assay. CSK stiffness and contractile tone in cultured PVSM cells increased in direct proportion as the density of fibronectin (FN) coating was raised from 10 to 500 ng/well in 96-well plates. Dibutyryl cGMP had no effect in cells on low FN, although it completely inhibited the FN-dependent increase in CSK stiffness on higher ECM densities. In contrast, ET-1 induced the greatest increase in CSK stiffness on the intermediate FN density (100 ng/well). The reduced sensitivity to ET-1 on high FN was not due to dysfunction of the contractile apparatus nor to changes in protein tyrosine phosphorylation. Taken together, these results show that ECM can modulate PVSM cell contractility and suggest that the changes in ECM observed in hypertensive vessels could play an important role in the etiology of this disease." @default.
• W2114011696 created "2016-06-24" @default.
• W2114011696 creator A5005669988 @default.
• W2114011696 creator A5037009590 @default.
• W2114011696 creator A5038554310 @default.
• W2114011696 creator A5043839950 @default.
• W2114011696 date "1998-01-01" @default.
• W2114011696 modified "2023-10-18" @default.
• W2114011696 title "Extracellular matrix and pulmonary hypertension: control of vascular smooth muscle cell contractility" @default.
• W2114011696 cites W1151817746 @default.
• W2114011696 cites W1519015673 @default.
• W2114011696 cites W1526496445 @default.
• W2114011696 cites W1578582539 @default.
• W2114011696 cites W1875615308 @default.
• W2114011696 cites W1964653374 @default.
• W2114011696 cites W1983352401 @default.
• W2114011696 cites W1997087774 @default.
• W2114011696 cites W1997814407 @default.
• W2114011696 cites W2002499520 @default.
• W2114011696 cites W2023800215 @default.
• W2114011696 cites W2024885580 @default.
• W2114011696 cites W2026327508 @default.
• W2114011696 cites W2026899181 @default.
• W2114011696 cites W2032295238 @default.
• W2114011696 cites W2045195255 @default.
• W2114011696 cites W2051417262 @default.
• W2114011696 cites W2052766715 @default.
• W2114011696 cites W2056327748 @default.
• W2114011696 cites W2067070004 @default.
• W2114011696 cites W2070064760 @default.
• W2114011696 cites W2089547011 @default.
• W2114011696 cites W2091281748 @default.
• W2114011696 cites W2109594092 @default.
• W2114011696 cites W2109803081 @default.
• W2114011696 cites W2117705371 @default.
• W2114011696 cites W2118461920 @default.
• W2114011696 cites W2130837666 @default.
• W2114011696 cites W2150102283 @default.
• W2114011696 cites W2322775779 @default.
• W2114011696 cites W2416541063 @default.
• W2114011696 doi "https://doi.org/10.1152/ajpheart.1998.274.1.h76" @default.
• W2114011696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9458854" @default.
• W2114011696 hasPublicationYear "1998" @default.
• W2114011696 type Work @default.
• W2114011696 sameAs 2114011696 @default.
• W2114011696 citedByCount "42" @default.
• W2114011696 countsByYear W21140116962012 @default.
• W2114011696 countsByYear W21140116962013 @default.
• W2114011696 countsByYear W21140116962014 @default.
• W2114011696 countsByYear W21140116962015 @default.
• W2114011696 countsByYear W21140116962016 @default.
• W2114011696 countsByYear W21140116962017 @default.
• W2114011696 countsByYear W21140116962018 @default.
• W2114011696 countsByYear W21140116962019 @default.
• W2114011696 countsByYear W21140116962022 @default.
• W2114011696 crossrefType "journal-article" @default.
• W2114011696 hasAuthorship W2114011696A5005669988 @default.
• W2114011696 hasAuthorship W2114011696A5037009590 @default.
• W2114011696 hasAuthorship W2114011696A5038554310 @default.
• W2114011696 hasAuthorship W2114011696A5043839950 @default.
• W2114011696 hasConcept C126322002 @default.
• W2114011696 hasConcept C134018914 @default.
• W2114011696 hasConcept C163415756 @default.
• W2114011696 hasConcept C185592680 @default.
• W2114011696 hasConcept C189165786 @default.
• W2114011696 hasConcept C2779395532 @default.
• W2114011696 hasConcept C28406088 @default.
• W2114011696 hasConcept C2992686903 @default.
• W2114011696 hasConcept C39133596 @default.
• W2114011696 hasConcept C55493867 @default.
• W2114011696 hasConcept C71924100 @default.
• W2114011696 hasConcept C86492073 @default.
• W2114011696 hasConcept C86803240 @default.
• W2114011696 hasConceptScore W2114011696C126322002 @default.
• W2114011696 hasConceptScore W2114011696C134018914 @default.
• W2114011696 hasConceptScore W2114011696C163415756 @default.
• W2114011696 hasConceptScore W2114011696C185592680 @default.
• W2114011696 hasConceptScore W2114011696C189165786 @default.
• W2114011696 hasConceptScore W2114011696C2779395532 @default.
• W2114011696 hasConceptScore W2114011696C28406088 @default.
• W2114011696 hasConceptScore W2114011696C2992686903 @default.
• W2114011696 hasConceptScore W2114011696C39133596 @default.
• W2114011696 hasConceptScore W2114011696C55493867 @default.
• W2114011696 hasConceptScore W2114011696C71924100 @default.
• W2114011696 hasConceptScore W2114011696C86492073 @default.
• W2114011696 hasConceptScore W2114011696C86803240 @default.
• W2114011696 hasIssue "1" @default.
• W2114011696 hasLocation W21140116961 @default.
• W2114011696 hasLocation W21140116962 @default.
• W2114011696 hasOpenAccess W2114011696 @default.
• W2114011696 hasPrimaryLocation W21140116961 @default.
• W2114011696 hasRelatedWork W1987177416 @default.
• W2114011696 hasRelatedWork W2077755216 @default.
• W2114011696 hasRelatedWork W2122859970 @default.
• W2114011696 hasRelatedWork W2130809134 @default.
• W2114011696 hasRelatedWork W2405863577 @default.
• W2114011696 hasRelatedWork W4250247120 @default.
• W2114011696 hasRelatedWork W4322493124 @default.

• next