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- W2114018387 abstract "The immune response consists of (1) antibody production and (2) a cell-mediated response which is expressed as delayed hypersensitivity. According to Good,1 this two-component system arises from the differentiation of stem cells from the bone marrow. One path leads to the establishment of epithelial buds in the intestinal tract, which produce plasma cells. These plasma cells spread to peripheral lymphoid tissues and ultimately lead to antibody formation. In the other path the stem cells contribute to the formation of the thymus gland, which is induced to become a lymphoid organ capable of controlling the production of small lymphocytes. These lymphocytes mediate delayed hypersensitivity and homograft rejection. In the chicken, the thymus controls the small lymphocytes; the of Fabricius in the hindgut gives rise to lymphoid cells, which are the precursors of antibody-making cells. In man, this separation of the immunological system is not as clearcut. Good provides evidence that adenoids, tonsils, and Peyers patches may be bursa equivalents, but the thymus of man controls some as¬ pects of antibody production as well as cellmediated responses. The cellular immunity system (thymus dependent) combines with the immunoglobulin-producing system (bursal dependent) in lymph nodes to complete the immunological defense system. In the normal baby, the thymus is fully developed at birth and the lymph nodes are well populated by thymus-primed small lymphocytes. However, the delayed hyper¬ sensitivity system (thymus dependent) does not reach full maturity until 5 months of age. The gut lymphoid tissue is also well de¬ veloped at birth, but lymph follicles and plasma cells appear only after the baby is antigenically challenged (ie, infection). An¬ tibody production (bursal dependent) is not fully developed until 7 to 9 months of age. During this critical developmental period, the infant is protected to some degree by immunoglobulins (IgG) received during fetal life. Immunological deficiency syndromes arise when the central lymphoid system fails to mature. The most severe form of arrested maturation of the immune mechanism is the Swiss lymphopenic agammaglobulinemia in which the thymus and the equivalents" @default.
- W2114018387 created "2016-06-24" @default.
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- W2114018387 date "1967-09-01" @default.
- W2114018387 modified "2023-09-26" @default.
- W2114018387 title "Selected Reviews of the Literature" @default.
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- W2114018387 doi "https://doi.org/10.1001/archderm.1967.01610030108018" @default.
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