FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114019504> ?p ?o ?g. }

• W2114019504 endingPage "167" @default.
• W2114019504 startingPage "157" @default.
• W2114019504 abstract "ABSTRACT: The human testis-specific lactate dehydrogenase c gene (hLdhc) is transcribed only in cells of the germinal epithelium. Recently hLdhc was reported to express in a broad spectrum of tumors with relatively high frequency in lung cancer, melanoma, and breast cancer, and in some prostate cancers. Two melanoma cell lines that express the hLdhc gene, A375M and C81–61, were identified and were used to characterize the hLdhc promoter and explore transcriptional regulation of this gene. A 110-bp core promoter, including a conserved GC box and cyclic adenosine monophosphate—responsive element (CRE), were identified as essential for basal promoter activity. The methylation status of the CpG island (CGI) in the hLdhc core promoter sequence was analyzed in hLdhc-expressing and nonexpressing cells and human prostate tumor tissues. The CGI in 2 cell lines expressing the gene was hypomethylated whereas the DNA from cells that did not express hLdhc was hypermethylated. The role of methylation in regulating this promoter was confirmed by experimental induction of hLdhc transcription with the methylation inhibitor 5′aza-deoxycytidine. Quantitative analyses of the methylation level in the CGI were performed in prostate tumor tissues by pyrosequencing. Overall, these experiments demonstrated that hLdhc expression in cancer cells was regulated by transcription factor Sp1 and CREB and promoter CGI methylation. In addition, these findings suggest the possibility of developing a biomarker for cancer diagnosis/prognosis based on DNA methylation of the Ldhc gene." @default.
• W2114019504 created "2016-06-24" @default.
• W2114019504 creator A5086040906 @default.
• W2114019504 creator A5089689990 @default.
• W2114019504 date "2008-10-30" @default.
• W2114019504 modified "2023-09-23" @default.
• W2114019504 title "Homo sapiens Lactate Dehydrogenase c (Ldhc) Gene Expression in Cancer Cells Is Regulated by Transcription Factor Sp1, CREB, and CpG Island Methylation" @default.
• W2114019504 cites W1481966721 @default.
• W2114019504 cites W1483737968 @default.
• W2114019504 cites W1484293540 @default.
• W2114019504 cites W1486257535 @default.
• W2114019504 cites W1504303645 @default.
• W2114019504 cites W1589013348 @default.
• W2114019504 cites W1601298699 @default.
• W2114019504 cites W1784857457 @default.
• W2114019504 cites W1800793451 @default.
• W2114019504 cites W1967064280 @default.
• W2114019504 cites W1968263601 @default.
• W2114019504 cites W1988499910 @default.
• W2114019504 cites W1990946086 @default.
• W2114019504 cites W1993947858 @default.
• W2114019504 cites W2006987944 @default.
• W2114019504 cites W2015260506 @default.
• W2114019504 cites W2028994134 @default.
• W2114019504 cites W2040149948 @default.
• W2114019504 cites W2042174530 @default.
• W2114019504 cites W2047837922 @default.
• W2114019504 cites W2057921510 @default.
• W2114019504 cites W2058218780 @default.
• W2114019504 cites W2069119371 @default.
• W2114019504 cites W2079842158 @default.
• W2114019504 cites W2096856481 @default.
• W2114019504 cites W2100475900 @default.
• W2114019504 cites W2116646376 @default.
• W2114019504 cites W2133410632 @default.
• W2114019504 cites W2158438223 @default.
• W2114019504 cites W2164065953 @default.
• W2114019504 cites W2167553025 @default.
• W2114019504 cites W2221405021 @default.
• W2114019504 cites W964221608 @default.
• W2114019504 doi "https://doi.org/10.2164/jandrol.108.005785" @default.
• W2114019504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18930904" @default.
• W2114019504 hasPublicationYear "2008" @default.
• W2114019504 type Work @default.
• W2114019504 sameAs 2114019504 @default.
• W2114019504 citedByCount "36" @default.
• W2114019504 countsByYear W21140195042012 @default.
• W2114019504 countsByYear W21140195042013 @default.
• W2114019504 countsByYear W21140195042014 @default.
• W2114019504 countsByYear W21140195042015 @default.
• W2114019504 countsByYear W21140195042016 @default.
• W2114019504 countsByYear W21140195042017 @default.
• W2114019504 countsByYear W21140195042018 @default.
• W2114019504 countsByYear W21140195042020 @default.
• W2114019504 countsByYear W21140195042021 @default.
• W2114019504 countsByYear W21140195042022 @default.
• W2114019504 countsByYear W21140195042023 @default.
• W2114019504 crossrefType "journal-article" @default.
• W2114019504 hasAuthorship W2114019504A5086040906 @default.
• W2114019504 hasAuthorship W2114019504A5089689990 @default.
• W2114019504 hasBestOaLocation W21140195041 @default.
• W2114019504 hasConcept C101762097 @default.
• W2114019504 hasConcept C104317684 @default.
• W2114019504 hasConcept C140173407 @default.
• W2114019504 hasConcept C150194340 @default.
• W2114019504 hasConcept C153911025 @default.
• W2114019504 hasConcept C190727270 @default.
• W2114019504 hasConcept C2779277951 @default.
• W2114019504 hasConcept C33288867 @default.
• W2114019504 hasConcept C37080517 @default.
• W2114019504 hasConcept C41091548 @default.
• W2114019504 hasConcept C502942594 @default.
• W2114019504 hasConcept C54355233 @default.
• W2114019504 hasConcept C86803240 @default.
• W2114019504 hasConceptScore W2114019504C101762097 @default.
• W2114019504 hasConceptScore W2114019504C104317684 @default.
• W2114019504 hasConceptScore W2114019504C140173407 @default.
• W2114019504 hasConceptScore W2114019504C150194340 @default.
• W2114019504 hasConceptScore W2114019504C153911025 @default.
• W2114019504 hasConceptScore W2114019504C190727270 @default.
• W2114019504 hasConceptScore W2114019504C2779277951 @default.
• W2114019504 hasConceptScore W2114019504C33288867 @default.
• W2114019504 hasConceptScore W2114019504C37080517 @default.
• W2114019504 hasConceptScore W2114019504C41091548 @default.
• W2114019504 hasConceptScore W2114019504C502942594 @default.
• W2114019504 hasConceptScore W2114019504C54355233 @default.
• W2114019504 hasConceptScore W2114019504C86803240 @default.
• W2114019504 hasIssue "2" @default.
• W2114019504 hasLocation W21140195041 @default.
• W2114019504 hasLocation W21140195042 @default.
• W2114019504 hasOpenAccess W2114019504 @default.
• W2114019504 hasPrimaryLocation W21140195041 @default.
• W2114019504 hasRelatedWork W1547949787 @default.
• W2114019504 hasRelatedWork W2054263979 @default.
• W2114019504 hasRelatedWork W2094569740 @default.
• W2114019504 hasRelatedWork W2126769386 @default.
• W2114019504 hasRelatedWork W2664211259 @default.
• W2114019504 hasRelatedWork W2900423390 @default.

• next