FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114036903> ?p ?o ?g. }

• W2114036903 endingPage "110" @default.
• W2114036903 startingPage "104" @default.
• W2114036903 abstract "Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia caused by the expansion of a hematopoietic progenitor cell that has acquired a mutation in the X-linked PIGA gene. PNH occurs on the background of bone marrow failure. Bone marrow failure and the presence of the abnormal cells account for the clinical phenotype of patients with PNH including hemolysis, cytopenia, and thrombophilia. PIGA is essential for the synthesis of glycosyl phosphatidylinositol (GPI) anchor molecules. PNH blood cells are therefore deficient in all proteins that use such an anchor molecule for attachment to the cell membrane. Two of these proteins regulate complement activation on the cell surface. Their deficiency therefore explains the exquisite sensitivity of PNH red blood cells to complement-mediated lysis. Complement-mediated lysis of red blood cells is intravascular, and intravascular hemolysis contributes significantly to the morbidity and mortality in patients with this condition. PNH is an outstanding example of how an increased understanding of pathophysiology may directly improve the diagnosis, care, and treatment of disease." @default.
• W2114036903 created "2016-06-24" @default.
• W2114036903 creator A5004217093 @default.
• W2114036903 creator A5058541998 @default.
• W2114036903 date "2008-01-01" @default.
• W2114036903 modified "2023-09-25" @default.
• W2114036903 title "The Pathophysiology of Disease in Patients with Paroxysmal Nocturnal Hemoglobinuria" @default.
• W2114036903 cites W121114518 @default.
• W2114036903 cites W1543877010 @default.
• W2114036903 cites W16534552 @default.
• W2114036903 cites W1664701446 @default.
• W2114036903 cites W1717575538 @default.
• W2114036903 cites W1795738503 @default.
• W2114036903 cites W1967949665 @default.
• W2114036903 cites W1970244706 @default.
• W2114036903 cites W1977982396 @default.
• W2114036903 cites W1978903726 @default.
• W2114036903 cites W1981635229 @default.
• W2114036903 cites W1985084429 @default.
• W2114036903 cites W1985967879 @default.
• W2114036903 cites W1990050859 @default.
• W2114036903 cites W1990943556 @default.
• W2114036903 cites W2002969519 @default.
• W2114036903 cites W2009387411 @default.
• W2114036903 cites W2019332372 @default.
• W2114036903 cites W2023377972 @default.
• W2114036903 cites W2030654802 @default.
• W2114036903 cites W2031941125 @default.
• W2114036903 cites W2033447059 @default.
• W2114036903 cites W2036431051 @default.
• W2114036903 cites W2040803934 @default.
• W2114036903 cites W2050603236 @default.
• W2114036903 cites W2054323447 @default.
• W2114036903 cites W2058082996 @default.
• W2114036903 cites W2061828150 @default.
• W2114036903 cites W2081978633 @default.
• W2114036903 cites W2087821203 @default.
• W2114036903 cites W2111315591 @default.
• W2114036903 cites W2116791780 @default.
• W2114036903 cites W2119152928 @default.
• W2114036903 cites W2129963947 @default.
• W2114036903 cites W2130696459 @default.
• W2114036903 cites W2131155793 @default.
• W2114036903 cites W2134914390 @default.
• W2114036903 cites W2141510833 @default.
• W2114036903 cites W2163165457 @default.
• W2114036903 cites W2169248562 @default.
• W2114036903 cites W2171912009 @default.
• W2114036903 cites W2229128134 @default.
• W2114036903 cites W2263840830 @default.
• W2114036903 cites W2323202050 @default.
• W2114036903 cites W2340165058 @default.
• W2114036903 cites W2340473219 @default.
• W2114036903 doi "https://doi.org/10.1182/asheducation-2008.1.104" @default.
• W2114036903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19074066" @default.
• W2114036903 hasPublicationYear "2008" @default.
• W2114036903 type Work @default.
• W2114036903 sameAs 2114036903 @default.
• W2114036903 citedByCount "32" @default.
• W2114036903 countsByYear W21140369032012 @default.
• W2114036903 countsByYear W21140369032013 @default.
• W2114036903 countsByYear W21140369032014 @default.
• W2114036903 countsByYear W21140369032015 @default.
• W2114036903 countsByYear W21140369032016 @default.
• W2114036903 countsByYear W21140369032017 @default.
• W2114036903 countsByYear W21140369032019 @default.
• W2114036903 countsByYear W21140369032020 @default.
• W2114036903 countsByYear W21140369032021 @default.
• W2114036903 countsByYear W21140369032022 @default.
• W2114036903 countsByYear W21140369032023 @default.
• W2114036903 crossrefType "journal-article" @default.
• W2114036903 hasAuthorship W2114036903A5004217093 @default.
• W2114036903 hasAuthorship W2114036903A5058541998 @default.
• W2114036903 hasBestOaLocation W21140369031 @default.
• W2114036903 hasConcept C10162356 @default.
• W2114036903 hasConcept C109159458 @default.
• W2114036903 hasConcept C111684460 @default.
• W2114036903 hasConcept C126322002 @default.
• W2114036903 hasConcept C184404459 @default.
• W2114036903 hasConcept C203014093 @default.
• W2114036903 hasConcept C2776175824 @default.
• W2114036903 hasConcept C2777346216 @default.
• W2114036903 hasConcept C2777991916 @default.
• W2114036903 hasConcept C2778639011 @default.
• W2114036903 hasConcept C2779902561 @default.
• W2114036903 hasConcept C2780007613 @default.
• W2114036903 hasConcept C2780366003 @default.
• W2114036903 hasConcept C2780525284 @default.
• W2114036903 hasConcept C28328180 @default.
• W2114036903 hasConcept C71924100 @default.
• W2114036903 hasConcept C79196540 @default.
• W2114036903 hasConcept C86803240 @default.
• W2114036903 hasConcept C8891405 @default.
• W2114036903 hasConcept C95444343 @default.
• W2114036903 hasConceptScore W2114036903C10162356 @default.
• W2114036903 hasConceptScore W2114036903C109159458 @default.
• W2114036903 hasConceptScore W2114036903C111684460 @default.
• W2114036903 hasConceptScore W2114036903C126322002 @default.

• next