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- W2114051710 abstract "Bis-(3'-5')-cyclic-di-guanosine monophosphate (c-di-GMP) is a bacterial signalling molecule produced by diguanylate cyclases (DGC, carrying GGDEF domains) and degraded by specific phosphodiesterases (PDE, carrying EAL domains). Neither its full physiological impact nor its effector mechanisms are currently understood. Also, the existence of multiple GGDEF/EAL genes in the genomes of most species raises questions about output specificity and robustness of c-di-GMP signalling. Using microarray and gene fusion analyses, we demonstrate that at least five of the 29 GGDEF/EAL genes in Escherichia coli are not only stationary phase-induced under the control of the general stress response master regulator sigma(S) (RpoS), but also exhibit differential control by additional environmental and temporal signals. Two of the corresponding proteins, YdaM (GGDEF only) and YciR (GGDEF + EAL), which in vitro show DGC and PDE activity, respectively, play an antagonistic role in the expression of the biofilm-associated curli fimbriae. This control occurs at the level of transcription of the curli and cellulose regulator CsgD. Moreover, we show that H-NS positively affects curli expression by inversely controlling the expression of ydaM and yciR. Furthermore, we demonstrate a temporally fine-tuned GGDEF cascade in which YdaM controls the expression of another GGDEF protein, YaiC. By genome-wide microarray analysis, evidence is provided that YdaM and YciR strongly and nearly exclusively control CsgD-regulated genes. We conclude that specific GGDEF/EAL proteins have very distinct expression patterns, and when present in physiological amounts, can act in a highly precise, non-global and perhaps microcompartmented manner on a few or even a single specific target(s)." @default.
- W2114051710 created "2016-06-24" @default.
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- W2114051710 date "2006-10-13" @default.
- W2114051710 modified "2023-10-12" @default.
- W2114051710 title "Cyclic‐di‐GMP‐mediated signalling within the σ<sup>S</sup> network of <i>Escherichia coli</i>" @default.
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- W2114051710 cites W1579756873 @default.
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- W2114051710 cites W1834673123 @default.
- W2114051710 cites W1886214354 @default.
- W2114051710 cites W1963147033 @default.
- W2114051710 cites W1966873172 @default.
- W2114051710 cites W1971004618 @default.
- W2114051710 cites W1974095677 @default.
- W2114051710 cites W1976347829 @default.
- W2114051710 cites W1977820570 @default.
- W2114051710 cites W1982658095 @default.
- W2114051710 cites W1990657825 @default.
- W2114051710 cites W1992733431 @default.
- W2114051710 cites W2001035552 @default.
- W2114051710 cites W2002013652 @default.
- W2114051710 cites W2004938907 @default.
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- W2114051710 cites W2146429915 @default.
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- W2114051710 cites W2151490567 @default.
- W2114051710 cites W2152155545 @default.
- W2114051710 cites W2153624566 @default.
- W2114051710 cites W2155581972 @default.
- W2114051710 cites W2158345344 @default.
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- W2114051710 doi "https://doi.org/10.1111/j.1365-2958.2006.05440.x" @default.
- W2114051710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17010156" @default.
- W2114051710 hasPublicationYear "2006" @default.
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