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• W2114053889 abstract "Amoeboid motility requires spatiotemporal coordination of biochemical pathways regulating force generation and consists of the quasi-periodic repetition of a motility cycle driven by actin polymerization and actomyosin contraction. Using new analytical tools and statistical methods, we provide, for the first time, a statistically significant quantification of the spatial distribution of the traction forces generated at each phase of the cycle (protrusion, contraction, retraction, and relaxation). We show that cells are constantly under tensional stress and that wild-type cells develop two opposing pole forces pulling the front and back toward the center whose strength is modulated up and down periodically in each cycle. We demonstrate that nonmuscular myosin II complex (MyoII) cross-linking and motor functions have different roles in controlling the spatiotemporal distribution of traction forces, the changes in cell shape, and the duration of all the phases. We show that the time required to complete each phase is dramatically increased in cells with altered MyoII motor function, demonstrating that it is required not only for contraction but also for protrusion. Concomitant loss of MyoII actin cross-linking leads to a force redistribution throughout the cell perimeter pulling inward toward the center. However, it does not reduce significantly the magnitude of the traction forces, uncovering a non-MyoII-mediated mechanism for the contractility of the cell." @default.
• W2114053889 created "2016-06-24" @default.
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• W2114053889 creator A5085766513 @default.
• W2114053889 date "2010-02-01" @default.
• W2114053889 modified "2023-10-13" @default.
• W2114053889 title "Myosin II Is Essential for the Spatiotemporal Organization of Traction Forces during Cell Motility" @default.
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• W2114053889 doi "https://doi.org/10.1091/mbc.e09-08-0703" @default.
• W2114053889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2814786" @default.
• W2114053889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19955212" @default.
• W2114053889 hasPublicationYear "2010" @default.
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