Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114072069> ?p ?o ?g. }
- W2114072069 abstract "Animal models of osteoarthritis are extensively used for investigating disease pathways and for preclinical testing of novel therapies. Their predictive utility, however, has often been questioned, mainly because preclinical efficacy of novel therapeutics is poorly translated in clinical trials. In the current narrative review, we consider the preclinical models that were used to support undertaking clinical trials for disease-modifying osteoarthritis drugs, and compare outcomes between clinical and preclinical studies. We discuss this in light of the 1999 Food and Drug Administration draft guidelines for industry for use in the development of drugs, devices, and biological products intended for the treatment of osteoarthritis, which raised five considerations on the usefulness of osteoarthritis models. We systematically discuss what has been learnt regarding these five points since 1999, with emphasis on replicating distinct risk factors and subtypes of human osteoarthritis, and on comprehensive evaluation of the disease in animals, including pathology of all joint tissues, biomarker analysis, and assessment of pain and joint function. Finally, we discuss lessons learnt and propose some recommendations for how the evidence from preclinical research might be strengthened with a view to improving success in clinical translation." @default.
- W2114072069 created "2016-06-24" @default.
- W2114072069 creator A5023553044 @default.
- W2114072069 creator A5067359842 @default.
- W2114072069 date "2015-09-14" @default.
- W2114072069 modified "2023-10-07" @default.
- W2114072069 title "On the predictive utility of animal models of osteoarthritis" @default.
- W2114072069 cites W131970863 @default.
- W2114072069 cites W143370592 @default.
- W2114072069 cites W1489821983 @default.
- W2114072069 cites W1497380422 @default.
- W2114072069 cites W1534458869 @default.
- W2114072069 cites W1560638706 @default.
- W2114072069 cites W1573431383 @default.
- W2114072069 cites W1584507582 @default.
- W2114072069 cites W1633314908 @default.
- W2114072069 cites W1707747547 @default.
- W2114072069 cites W171392482 @default.
- W2114072069 cites W1718779047 @default.
- W2114072069 cites W178991289 @default.
- W2114072069 cites W1833090196 @default.
- W2114072069 cites W1965665343 @default.
- W2114072069 cites W1967105697 @default.
- W2114072069 cites W1969123415 @default.
- W2114072069 cites W1971088842 @default.
- W2114072069 cites W1972070267 @default.
- W2114072069 cites W1972622558 @default.
- W2114072069 cites W1974006781 @default.
- W2114072069 cites W1977362731 @default.
- W2114072069 cites W1979683246 @default.
- W2114072069 cites W1981352055 @default.
- W2114072069 cites W1982429227 @default.
- W2114072069 cites W1982735238 @default.
- W2114072069 cites W1982917662 @default.
- W2114072069 cites W1985973049 @default.
- W2114072069 cites W1987402568 @default.
- W2114072069 cites W1994841765 @default.
- W2114072069 cites W1994880204 @default.
- W2114072069 cites W1994922556 @default.
- W2114072069 cites W1997362383 @default.
- W2114072069 cites W1999158053 @default.
- W2114072069 cites W2002251686 @default.
- W2114072069 cites W2005381591 @default.
- W2114072069 cites W2006301331 @default.
- W2114072069 cites W2007936528 @default.
- W2114072069 cites W2009446773 @default.
- W2114072069 cites W2009627812 @default.
- W2114072069 cites W2011227409 @default.
- W2114072069 cites W2011578056 @default.
- W2114072069 cites W2013743316 @default.
- W2114072069 cites W2014796138 @default.
- W2114072069 cites W2014980907 @default.
- W2114072069 cites W2017700873 @default.
- W2114072069 cites W2019382321 @default.
- W2114072069 cites W2022219238 @default.
- W2114072069 cites W2022494152 @default.
- W2114072069 cites W2022675941 @default.
- W2114072069 cites W2022830774 @default.
- W2114072069 cites W2023454848 @default.
- W2114072069 cites W2023881992 @default.
- W2114072069 cites W2025797414 @default.
- W2114072069 cites W2026025998 @default.
- W2114072069 cites W2026123588 @default.
- W2114072069 cites W2028920679 @default.
- W2114072069 cites W2032267692 @default.
- W2114072069 cites W2034124533 @default.
- W2114072069 cites W2034714544 @default.
- W2114072069 cites W2035464830 @default.
- W2114072069 cites W2036295102 @default.
- W2114072069 cites W2036703631 @default.
- W2114072069 cites W2038089520 @default.
- W2114072069 cites W2038345799 @default.
- W2114072069 cites W2039078594 @default.
- W2114072069 cites W2040266551 @default.
- W2114072069 cites W2041173066 @default.
- W2114072069 cites W2041369782 @default.
- W2114072069 cites W2042604647 @default.
- W2114072069 cites W2045089882 @default.
- W2114072069 cites W2046266055 @default.
- W2114072069 cites W2046334149 @default.
- W2114072069 cites W2047284055 @default.
- W2114072069 cites W2047734268 @default.
- W2114072069 cites W2050228742 @default.
- W2114072069 cites W2051725755 @default.
- W2114072069 cites W2052666670 @default.
- W2114072069 cites W2053830789 @default.
- W2114072069 cites W2056369910 @default.
- W2114072069 cites W2056743394 @default.
- W2114072069 cites W2058435889 @default.
- W2114072069 cites W2059034217 @default.
- W2114072069 cites W2059075721 @default.
- W2114072069 cites W2059670411 @default.
- W2114072069 cites W2060951121 @default.
- W2114072069 cites W2062652371 @default.
- W2114072069 cites W2063391683 @default.
- W2114072069 cites W2063676853 @default.
- W2114072069 cites W2065295131 @default.
- W2114072069 cites W2069897989 @default.
- W2114072069 cites W2071718640 @default.
- W2114072069 cites W2072709321 @default.