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- W2114080768 abstract "Adherent cells remodel their cytoskeleton, including its directionality, in response to directional mechanical stimuli with consequent redistribution of intracellular forces and modulation of cell function. We analyzed the temporal and spatial changes in magnitude and directionality of the cytoplasmic creep compliance (Γ) in confluent cultures of bovine aortic endothelial cells subjected to continuous laminar flow shear stresses. We extended particle tracking microrheology to determine at each point in the cytoplasm the principal directions along which Γ is maximal and minimal. Under static condition, the cells have polygonal shapes without specific alignment. Although Γ of each cell exhibits directionality with varying principal directions, Γ averaged over the whole cell population is isotropic. After continuous laminar flow shear stresses, all cells gradually elongate and the directions of maximal and minimal Γ become, respectively, parallel and perpendicular to flow direction. This mechanical alignment is accompanied by a transition of the cytoplasm to be more fluid-like along the flow direction and more solid-like along the perpendicular direction; at the same time Γ increases at the downstream part of the cells. The resulting directional anisotropy and spatial inhomogeneity of cytoplasmic rheology may play an important role in mechanotransduction in adherent cells by providing a means to sense the direction of mechanical stimuli." @default.
- W2114080768 created "2016-06-24" @default.
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- W2114080768 date "2008-10-07" @default.
- W2114080768 modified "2023-10-01" @default.
- W2114080768 title "Anisotropic rheology and directional mechanotransduction in vascular endothelial cells" @default.
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- W2114080768 doi "https://doi.org/10.1073/pnas.0804573105" @default.
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