FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114083417> ?p ?o ?g. }

• W2114083417 endingPage "1375" @default.
• W2114083417 startingPage "1375" @default.
• W2114083417 abstract "In response to our recent article which demonstrated discordance in expression of estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) between matched primary breast cancer and nodal metastases [1.Aitken S.J. Thomas J.S. Langdon S.P. et al.Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases.Ann Oncol. 2010; 21: 1254-1261Abstract Full Text Full Text PDF PubMed Scopus (145) Google Scholar], Lopez-Bonet and Menendez [2.Lopez-Bonet E. Menendez J.A. Discordant expression of molecular markers between primary and nodal metastases: a histopathological manifestation of the ‘self (stem cell)-seeding’ nature of breast cancer disease?.Ann Oncol. 2010; 21: 901-902Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar] raise the intriguing possibility that these observations might represent a histopathological manifestation of the self-seeding nature of breast cancer, originally proposed by Norton and Massague [3.Norton L. Massague J. Is cancer a disease of self-seeding?.Nat Med. 2006; 12: 875-878Crossref PubMed Scopus (288) Google Scholar]. In this model, cancer growth can be explained not just by local spread but also by relocation of cancer cells via circulatory flow either to the primary site or to distant sites, where tumor growth then continues by proliferation, angiogenesis, and self-seeding. Lopez-Bonet and Menendez [2.Lopez-Bonet E. Menendez J.A. Discordant expression of molecular markers between primary and nodal metastases: a histopathological manifestation of the ‘self (stem cell)-seeding’ nature of breast cancer disease?.Ann Oncol. 2010; 21: 901-902Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar] go on to indicate that by comparing differences in immunohistochemical (IHC) profiles in primary and metastatic disease, it might be possible to investigate the dynamics of flow between primary and distant disease from a self-seeding perspective and ultimately elucidate which gene sets mediate the biological processes of metastasis either back to the primary site or to a distant site. According to this model, in node-positive breast tumors which are, by definition, biologically aggressive, those tumors with the same IHC-detected profiles in primary and metastatic disease are predicted to be smaller than those with discordant IHC profiles since smaller tumors with metastases already possess metastasis-competent gene sets mediating balanced traffic between local and distant sites. Larger tumors have unbalanced and discontinuous seeding and a self-determining local microevolution at the different sites mediated by different gene sets. In our study, tumors with the same molecular phenotype (defined by ER, PgR and HER2 staining) in primary and nodal metastases are significantly smaller than those with discordant molecular phenotypes between primary and nodal metastases (27.1 versus 32.0 mm, P = 0.036, student’s t-test), in keeping with this hypothesis. No significant differences were seen in the histological grade or the number of positive nodes between similar or discordant groups; however, this does not disprove the hypothesis since grade is a relatively nonquantitative measure of those parameters which might be expected to be different between sites (e.g. proliferation) and the number of positive nodes might be influenced by other factors independent of seeding capacity, such as circulation dynamics. These data support the notion that IHC profiling of primary and distant disease in this way might prove a useful surrogate of the dynamics of tumor spread. Therefore, molecular definition of cohorts of primary and distant breast cancer using quantitative immunofluorescence might provide useful experimental comparators in order to elucidate common pathways of growth and metastasis to local or distant sites. Including these subpopulations in any systematic analysis of gene expression of primary and distant breast cancer might help establish mechanisms of metastasis. Breakthrough Breast Cancer; Scottish Funding Council (Strategic Research Development Grant) (HR070005). Molecular pathology on tissue was supported by the Edinburgh Cancer Research UK Experimental Cancer Medicine Centre." @default.
• W2114083417 created "2016-06-24" @default.
• W2114083417 creator A5009340780 @default.
• W2114083417 creator A5013140743 @default.
• W2114083417 creator A5041581672 @default.
• W2114083417 creator A5067780711 @default.
• W2114083417 creator A5076006917 @default.
• W2114083417 date "2010-06-01" @default.
• W2114083417 modified "2023-09-24" @default.
• W2114083417 title "Reply to: Discordant expression of molecular markers between primary and nodal metastases: a histopathological manifestation of the ‘self (stem cell)-seeding’ nature of breast cancer disease?" @default.
• W2114083417 cites W2024331903 @default.
• W2114083417 cites W2113233663 @default.
• W2114083417 cites W2146511459 @default.
• W2114083417 doi "https://doi.org/10.1093/annonc/mdq046" @default.
• W2114083417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20215137" @default.
• W2114083417 hasPublicationYear "2010" @default.
• W2114083417 type Work @default.
• W2114083417 sameAs 2114083417 @default.
• W2114083417 citedByCount "0" @default.
• W2114083417 crossrefType "journal-article" @default.
• W2114083417 hasAuthorship W2114083417A5009340780 @default.
• W2114083417 hasAuthorship W2114083417A5013140743 @default.
• W2114083417 hasAuthorship W2114083417A5041581672 @default.
• W2114083417 hasAuthorship W2114083417A5067780711 @default.
• W2114083417 hasAuthorship W2114083417A5076006917 @default.
• W2114083417 hasBestOaLocation W21140834171 @default.
• W2114083417 hasConcept C121608353 @default.
• W2114083417 hasConcept C126322002 @default.
• W2114083417 hasConcept C142724271 @default.
• W2114083417 hasConcept C143998085 @default.
• W2114083417 hasConcept C2779013556 @default.
• W2114083417 hasConcept C2780283643 @default.
• W2114083417 hasConcept C2780394083 @default.
• W2114083417 hasConcept C502942594 @default.
• W2114083417 hasConcept C530470458 @default.
• W2114083417 hasConcept C55427017 @default.
• W2114083417 hasConcept C71924100 @default.
• W2114083417 hasConcept C84606932 @default.
• W2114083417 hasConceptScore W2114083417C121608353 @default.
• W2114083417 hasConceptScore W2114083417C126322002 @default.
• W2114083417 hasConceptScore W2114083417C142724271 @default.
• W2114083417 hasConceptScore W2114083417C143998085 @default.
• W2114083417 hasConceptScore W2114083417C2779013556 @default.
• W2114083417 hasConceptScore W2114083417C2780283643 @default.
• W2114083417 hasConceptScore W2114083417C2780394083 @default.
• W2114083417 hasConceptScore W2114083417C502942594 @default.
• W2114083417 hasConceptScore W2114083417C530470458 @default.
• W2114083417 hasConceptScore W2114083417C55427017 @default.
• W2114083417 hasConceptScore W2114083417C71924100 @default.
• W2114083417 hasConceptScore W2114083417C84606932 @default.
• W2114083417 hasIssue "6" @default.
• W2114083417 hasLocation W21140834171 @default.
• W2114083417 hasLocation W21140834172 @default.
• W2114083417 hasOpenAccess W2114083417 @default.
• W2114083417 hasPrimaryLocation W21140834171 @default.
• W2114083417 hasRelatedWork W2224319365 @default.
• W2114083417 hasRelatedWork W2358524972 @default.
• W2114083417 hasRelatedWork W2791088259 @default.
• W2114083417 hasRelatedWork W2998402275 @default.
• W2114083417 hasRelatedWork W3114532332 @default.
• W2114083417 hasRelatedWork W3175984978 @default.
• W2114083417 hasRelatedWork W3206864557 @default.
• W2114083417 hasRelatedWork W4283771460 @default.
• W2114083417 hasRelatedWork W4311669536 @default.
• W2114083417 hasRelatedWork W4361824799 @default.
• W2114083417 hasVolume "21" @default.
• W2114083417 isParatext "false" @default.
• W2114083417 isRetracted "false" @default.
• W2114083417 magId "2114083417" @default.
• W2114083417 workType "article" @default.