FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114090139> ?p ?o ?g. }

• W2114090139 endingPage "105" @default.
• W2114090139 startingPage "90" @default.
• W2114090139 abstract "Oxaliplatin is a relatively new platinum analogue that is currently used in pharmacotherapy of metastatic colorectal cancer. Its dose-limiting toxicity is sensory neuropathy, which can be modulated by infusion of calcium and magnesium. Oxaliplatin exerts its anti-tumour effects by platinum-adduct formation, binding to cellular proteins and possibly interfering with RNA synthesis as well. If they are not removed from DNA, oxaliplatin adducts are lethal. Cellular defense mechanisms prevent adduct formation (e.g., glutathione-S-transferase) or remove DNA adducts (e.g., nucleotide excision repair). Depending on the activity of necessary enzymes in these cellular defense pathways, oxaliplatin induced damage varies from one individual to another. There is growing evidence that polymorphisms in genes coding for DNA repair enzymes and metabolic inactivation routes contribute to the interindividual differences in anti-tumour efficacy and toxicity of oxaliplatin. Single nucleotide polymorphisms (SNPs) may yield inactive enzymes, or increased gene transcription and hence increased enzyme production. This review covers findings of recent investigations on the associations of SNPs and clinical outcome after oxaliplatin chemotherapy in metastatic colorectal cancer." @default.
• W2114090139 created "2016-06-24" @default.
• W2114090139 creator A5025935523 @default.
• W2114090139 creator A5030957904 @default.
• W2114090139 creator A5063903295 @default.
• W2114090139 date "2005-04-01" @default.
• W2114090139 modified "2023-10-02" @default.
• W2114090139 title "Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy" @default.
• W2114090139 cites W114710312 @default.
• W2114090139 cites W145530960 @default.
• W2114090139 cites W145577621 @default.
• W2114090139 cites W1500146879 @default.
• W2114090139 cites W1541218357 @default.
• W2114090139 cites W1571883215 @default.
• W2114090139 cites W1572569028 @default.
• W2114090139 cites W1802949207 @default.
• W2114090139 cites W1964821477 @default.
• W2114090139 cites W1968469810 @default.
• W2114090139 cites W1969819377 @default.
• W2114090139 cites W1980043895 @default.
• W2114090139 cites W1982563907 @default.
• W2114090139 cites W1983585864 @default.
• W2114090139 cites W1986876550 @default.
• W2114090139 cites W1993532042 @default.
• W2114090139 cites W1998226812 @default.
• W2114090139 cites W2000983378 @default.
• W2114090139 cites W2001959293 @default.
• W2114090139 cites W2004103693 @default.
• W2114090139 cites W2013889785 @default.
• W2114090139 cites W2016083786 @default.
• W2114090139 cites W2019118465 @default.
• W2114090139 cites W2019967255 @default.
• W2114090139 cites W2022594395 @default.
• W2114090139 cites W2027245434 @default.
• W2114090139 cites W2035114393 @default.
• W2114090139 cites W2039633811 @default.
• W2114090139 cites W2040289024 @default.
• W2114090139 cites W2045714155 @default.
• W2114090139 cites W2061353549 @default.
• W2114090139 cites W2063919832 @default.
• W2114090139 cites W2065829703 @default.
• W2114090139 cites W2084408059 @default.
• W2114090139 cites W2098645377 @default.
• W2114090139 cites W2099154608 @default.
• W2114090139 cites W2102550332 @default.
• W2114090139 cites W2103438630 @default.
• W2114090139 cites W2105483695 @default.
• W2114090139 cites W2108023430 @default.
• W2114090139 cites W2108081406 @default.
• W2114090139 cites W2108208897 @default.
• W2114090139 cites W2111025829 @default.
• W2114090139 cites W2111413471 @default.
• W2114090139 cites W2113745932 @default.
• W2114090139 cites W2115731832 @default.
• W2114090139 cites W2119320819 @default.
• W2114090139 cites W2119963779 @default.
• W2114090139 cites W2121368761 @default.
• W2114090139 cites W2123133140 @default.
• W2114090139 cites W2127449669 @default.
• W2114090139 cites W2128403792 @default.
• W2114090139 cites W2137234355 @default.
• W2114090139 cites W2139848821 @default.
• W2114090139 cites W2141481588 @default.
• W2114090139 cites W2143238378 @default.
• W2114090139 cites W2144486308 @default.
• W2114090139 cites W2148361462 @default.
• W2114090139 cites W2148622949 @default.
• W2114090139 cites W2156214772 @default.
• W2114090139 cites W2160234875 @default.
• W2114090139 cites W2162542458 @default.
• W2114090139 cites W2165978958 @default.
• W2114090139 cites W2170475716 @default.
• W2114090139 cites W2171232394 @default.
• W2114090139 cites W2171366906 @default.
• W2114090139 cites W2175773713 @default.
• W2114090139 cites W2182816319 @default.
• W2114090139 cites W2219851884 @default.
• W2114090139 cites W2226350586 @default.
• W2114090139 cites W2281733501 @default.
• W2114090139 cites W2285405079 @default.
• W2114090139 cites W2299418281 @default.
• W2114090139 cites W2331348829 @default.
• W2114090139 cites W2604284359 @default.
• W2114090139 cites W2604610201 @default.
• W2114090139 cites W2749154569 @default.
• W2114090139 doi "https://doi.org/10.1016/j.ctrv.2004.12.006" @default.
• W2114090139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15847979" @default.
• W2114090139 hasPublicationYear "2005" @default.
• W2114090139 type Work @default.
• W2114090139 sameAs 2114090139 @default.
• W2114090139 citedByCount "162" @default.
• W2114090139 countsByYear W21140901392012 @default.
• W2114090139 countsByYear W21140901392013 @default.
• W2114090139 countsByYear W21140901392014 @default.
• W2114090139 countsByYear W21140901392015 @default.
• W2114090139 countsByYear W21140901392016 @default.
• W2114090139 countsByYear W21140901392017 @default.
• W2114090139 countsByYear W21140901392018 @default.

• next