Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114094740> ?p ?o ?g. }
- W2114094740 endingPage "387" @default.
- W2114094740 startingPage "378" @default.
- W2114094740 abstract "It is unclear what factors control the secretion of pulmonary surface active material from alveolar type II cells in vivo. Other workers have suggested that cholinergic stimuli, adrenergic stimuli, and prostaglandins may all stimulate secretion. We isolated type II cells from the lungs of rats by treatment with elastase, discontinuous density centrifugation, and adherence in primary culture. β-Adrenergic agonists, but not cholinergic agonists, caused an increase in the release of [14C]disaturated phosphatidylcholine, the major component of surface-active material, from type II cells in culture. The β-adrenergic effect was stereo-selective, (−)-isoproterenol being 50 times more potent than (+)-isoproterenol. Terbutaline, 10 μM, a noncatecholamine β-2 adrenergic agonist, caused a release of 2.0±0.5 (mean±SD) times the basal release of [14C]disaturated phosphatidylcholine in 3 h; the concentration of terbutaline causing half maximal stimulation was 800 nM. The terbutaline effect was blocked by propranolol, a β-adrenergic antagonist (calculated Kd = 6 nM), but not by phentolamine, an α-adrenergic antagonist. Isobutylmethylxanthine, a phosphodiesterase inhibitor, and 8-Br cyclic AMP, but not 8-Br cyclic guanosine monophosphate, also stimulated release. We conclude that type II cells secrete disaturated phosphatidylcholine in response to treatment with adrenergic stimulation." @default.
- W2114094740 created "2016-06-24" @default.
- W2114094740 creator A5009526225 @default.
- W2114094740 creator A5032305865 @default.
- W2114094740 date "1979-03-01" @default.
- W2114094740 modified "2023-10-15" @default.
- W2114094740 title "Pulmonary Alveolar Type II Cells Isolated from Rats" @default.
- W2114094740 cites W1568806088 @default.
- W2114094740 cites W1578828922 @default.
- W2114094740 cites W1593155586 @default.
- W2114094740 cites W1631610937 @default.
- W2114094740 cites W1739677062 @default.
- W2114094740 cites W1800995402 @default.
- W2114094740 cites W1833212931 @default.
- W2114094740 cites W1840067061 @default.
- W2114094740 cites W1889564238 @default.
- W2114094740 cites W1966497279 @default.
- W2114094740 cites W1972718866 @default.
- W2114094740 cites W1975176230 @default.
- W2114094740 cites W1983981610 @default.
- W2114094740 cites W1989688933 @default.
- W2114094740 cites W1990944361 @default.
- W2114094740 cites W1992933633 @default.
- W2114094740 cites W2004314923 @default.
- W2114094740 cites W2012455234 @default.
- W2114094740 cites W2025337760 @default.
- W2114094740 cites W2048674770 @default.
- W2114094740 cites W2054602475 @default.
- W2114094740 cites W2059496748 @default.
- W2114094740 cites W2063094866 @default.
- W2114094740 cites W2074631079 @default.
- W2114094740 cites W2077915285 @default.
- W2114094740 cites W2083975017 @default.
- W2114094740 cites W2094142408 @default.
- W2114094740 cites W2116453093 @default.
- W2114094740 cites W2119077292 @default.
- W2114094740 cites W2155502587 @default.
- W2114094740 cites W2168526937 @default.
- W2114094740 cites W2181010858 @default.
- W2114094740 cites W2196365430 @default.
- W2114094740 cites W2232511631 @default.
- W2114094740 cites W2252659591 @default.
- W2114094740 cites W2271873189 @default.
- W2114094740 cites W2338096946 @default.
- W2114094740 cites W2346960455 @default.
- W2114094740 cites W2403171862 @default.
- W2114094740 cites W2408496749 @default.
- W2114094740 cites W2413983995 @default.
- W2114094740 cites W2414233442 @default.
- W2114094740 cites W2414741912 @default.
- W2114094740 cites W2416428166 @default.
- W2114094740 cites W2419597834 @default.
- W2114094740 cites W2425922456 @default.
- W2114094740 cites W83218127 @default.
- W2114094740 cites W2164352421 @default.
- W2114094740 doi "https://doi.org/10.1172/jci109313" @default.
- W2114094740 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/371964" @default.
- W2114094740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34631" @default.
- W2114094740 hasPublicationYear "1979" @default.
- W2114094740 type Work @default.
- W2114094740 sameAs 2114094740 @default.
- W2114094740 citedByCount "336" @default.
- W2114094740 countsByYear W21140947402013 @default.
- W2114094740 countsByYear W21140947402014 @default.
- W2114094740 countsByYear W21140947402015 @default.
- W2114094740 countsByYear W21140947402016 @default.
- W2114094740 countsByYear W21140947402017 @default.
- W2114094740 countsByYear W21140947402018 @default.
- W2114094740 countsByYear W21140947402019 @default.
- W2114094740 crossrefType "journal-article" @default.
- W2114094740 hasAuthorship W2114094740A5009526225 @default.
- W2114094740 hasAuthorship W2114094740A5032305865 @default.
- W2114094740 hasBestOaLocation W21140947401 @default.
- W2114094740 hasConcept C126322002 @default.
- W2114094740 hasConcept C134018914 @default.
- W2114094740 hasConcept C158453852 @default.
- W2114094740 hasConcept C170493617 @default.
- W2114094740 hasConcept C181199279 @default.
- W2114094740 hasConcept C185592680 @default.
- W2114094740 hasConcept C22885893 @default.
- W2114094740 hasConcept C24998067 @default.
- W2114094740 hasConcept C2776042228 @default.
- W2114094740 hasConcept C2776330855 @default.
- W2114094740 hasConcept C2776766087 @default.
- W2114094740 hasConcept C2776885963 @default.
- W2114094740 hasConcept C2778151854 @default.
- W2114094740 hasConcept C2778196918 @default.
- W2114094740 hasConcept C2778918659 @default.
- W2114094740 hasConcept C2780252434 @default.
- W2114094740 hasConcept C2780253649 @default.
- W2114094740 hasConcept C2908653273 @default.
- W2114094740 hasConcept C41625074 @default.
- W2114094740 hasConcept C49039625 @default.
- W2114094740 hasConcept C55493867 @default.
- W2114094740 hasConcept C62826618 @default.
- W2114094740 hasConcept C71924100 @default.
- W2114094740 hasConcept C86803240 @default.
- W2114094740 hasConceptScore W2114094740C126322002 @default.