FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114117815> ?p ?o ?g. }

• W2114117815 endingPage "186" @default.
• W2114117815 startingPage "181" @default.
• W2114117815 abstract "Problem statement: The role of 5-HT has been investigated in many behavioral activities.Thus, studies using raphe lesion showed that 5-HT is involved in sleep, general activity levels,habituation, aggression, pain sensitivity and morphine analgesia, avoidance behavior, self-stimulationand water consumption. Approach: The metabolic interaction between serotonin (5-hydroxytrptamine) and indole-3-aldehyde and xanthine via aldehyde oxidase (EC 1.2.3.1) and xanthineoxidase (EC 1.1.3.22), respectively, were studied in liver tissue homogenate of Dunkin-Hartley guineapigs by following the decrease in substrate concentration using spectrophotometer. Homogenates ofliver were incubated with indole-3-aldehyde in the presence and absence of serotonin or(chlorpromazine and allopurinol a potent and selective inhibitors for aldehyde oxidase and xanthineoxidase, respectively). Oxidation of indole-3-aldehyde to indole-3-acetic acid was reduced up to 63.2%in the presence of serotonin (100 µM), while oxidation of xanthine to uric acid was reduced up to 51.6% under the same conditions. Results: In comparison, incubation of the substrates with their specific inhibitors (100 µM of chlorpromazine and 100 µM allopurinol) give almost complete inhibition. These results demonstrate that in the guinea pig liver a metabolic interaction between serotonin and indole-3-aldehyde or xanthine via molybdenum hydroxylases system may take place in liver, which is the main tissue for xenobiotics detoxification. Conclusion: The overall conclusion from this research is that serotonin could be a protector for neurons and other tissue from the insult of oxidation of aldehydes and xanthines by molybdenum hydroxylases." @default.
• W2114117815 created "2016-06-24" @default.
• W2114117815 creator A5014942731 @default.
• W2114117815 creator A5040656999 @default.
• W2114117815 creator A5083702254 @default.
• W2114117815 date "2010-03-01" @default.
• W2114117815 modified "2023-09-27" @default.
• W2114117815 title "<i>In Vitro</i> Interaction of 5-Hydroxytrptamine with Cytosolic Molybdenum Hydroxylases as a Potential Inhibitor for Initial Rates Activities" @default.
• W2114117815 cites W1974782548 @default.
• W2114117815 cites W1977340264 @default.
• W2114117815 cites W1985881006 @default.
• W2114117815 cites W1988394934 @default.
• W2114117815 cites W1995544598 @default.
• W2114117815 cites W2001277124 @default.
• W2114117815 cites W2002366750 @default.
• W2114117815 cites W2004969635 @default.
• W2114117815 cites W2011680511 @default.
• W2114117815 cites W2020460680 @default.
• W2114117815 cites W2031694081 @default.
• W2114117815 cites W2038174426 @default.
• W2114117815 cites W2038556042 @default.
• W2114117815 cites W2040835124 @default.
• W2114117815 cites W2045290451 @default.
• W2114117815 cites W2048434982 @default.
• W2114117815 cites W2055360560 @default.
• W2114117815 cites W2062053200 @default.
• W2114117815 cites W2064826671 @default.
• W2114117815 cites W2065583447 @default.
• W2114117815 cites W2066698911 @default.
• W2114117815 cites W2072853796 @default.
• W2114117815 cites W2081622555 @default.
• W2114117815 cites W2082010745 @default.
• W2114117815 cites W2089084925 @default.
• W2114117815 cites W2094056283 @default.
• W2114117815 cites W2100438158 @default.
• W2114117815 cites W2124177365 @default.
• W2114117815 cites W2155757287 @default.
• W2114117815 cites W2165452325 @default.
• W2114117815 cites W2423630542 @default.
• W2114117815 doi "https://doi.org/10.3844/ajbbsp.2010.181.186" @default.
• W2114117815 hasPublicationYear "2010" @default.
• W2114117815 type Work @default.
• W2114117815 sameAs 2114117815 @default.
• W2114117815 citedByCount "0" @default.
• W2114117815 crossrefType "journal-article" @default.
• W2114117815 hasAuthorship W2114117815A5014942731 @default.
• W2114117815 hasAuthorship W2114117815A5040656999 @default.
• W2114117815 hasAuthorship W2114117815A5083702254 @default.
• W2114117815 hasBestOaLocation W21141178151 @default.
• W2114117815 hasConcept C126322002 @default.
• W2114117815 hasConcept C151400659 @default.
• W2114117815 hasConcept C170493617 @default.
• W2114117815 hasConcept C181199279 @default.
• W2114117815 hasConcept C185592680 @default.
• W2114117815 hasConcept C2775864247 @default.
• W2114117815 hasConcept C2778102346 @default.
• W2114117815 hasConcept C2779470414 @default.
• W2114117815 hasConcept C2779840689 @default.
• W2114117815 hasConcept C2780261098 @default.
• W2114117815 hasConcept C55493867 @default.
• W2114117815 hasConcept C71924100 @default.
• W2114117815 hasConcept C86803240 @default.
• W2114117815 hasConcept C98274493 @default.
• W2114117815 hasConceptScore W2114117815C126322002 @default.
• W2114117815 hasConceptScore W2114117815C151400659 @default.
• W2114117815 hasConceptScore W2114117815C170493617 @default.
• W2114117815 hasConceptScore W2114117815C181199279 @default.
• W2114117815 hasConceptScore W2114117815C185592680 @default.
• W2114117815 hasConceptScore W2114117815C2775864247 @default.
• W2114117815 hasConceptScore W2114117815C2778102346 @default.
• W2114117815 hasConceptScore W2114117815C2779470414 @default.
• W2114117815 hasConceptScore W2114117815C2779840689 @default.
• W2114117815 hasConceptScore W2114117815C2780261098 @default.
• W2114117815 hasConceptScore W2114117815C55493867 @default.
• W2114117815 hasConceptScore W2114117815C71924100 @default.
• W2114117815 hasConceptScore W2114117815C86803240 @default.
• W2114117815 hasConceptScore W2114117815C98274493 @default.
• W2114117815 hasIssue "3" @default.
• W2114117815 hasLocation W21141178151 @default.
• W2114117815 hasOpenAccess W2114117815 @default.
• W2114117815 hasPrimaryLocation W21141178151 @default.
• W2114117815 hasRelatedWork W1510746941 @default.
• W2114117815 hasRelatedWork W1997442234 @default.
• W2114117815 hasRelatedWork W2010403283 @default.
• W2114117815 hasRelatedWork W2046360546 @default.
• W2114117815 hasRelatedWork W2054005538 @default.
• W2114117815 hasRelatedWork W2054266698 @default.
• W2114117815 hasRelatedWork W2064624515 @default.
• W2114117815 hasRelatedWork W2068595224 @default.
• W2114117815 hasRelatedWork W2071861802 @default.
• W2114117815 hasRelatedWork W2078673639 @default.
• W2114117815 hasRelatedWork W2123658510 @default.
• W2114117815 hasRelatedWork W2131069678 @default.
• W2114117815 hasRelatedWork W2157418130 @default.
• W2114117815 hasRelatedWork W2221899918 @default.
• W2114117815 hasRelatedWork W2319104114 @default.
• W2114117815 hasRelatedWork W2395393493 @default.
• W2114117815 hasRelatedWork W2465839450 @default.

• next