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- W2114125544 abstract "It has been known for more than half a century that the tumor microvasculature is hyperpermeable to plasma proteins. However, the identity of the leaky vessels and the consequences of vascular hyperpermeability have received little attention. This article places tumor vascular hyperpermeability in a broader context, relating it to (1) the low-level basal permeability of the normal vasculature; (2) the acute, short-term hyperpermeability induced by vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) and other vascular permeabilizing agents; and (3) the chronic hyperpermeability associated with longer-term exposure to agents such as VPF/VEGF-A that accompanies many types of pathological angiogenesis. Leakage of plasma protein-rich fluids is important because it activates the clotting system, depositing an extravascular fibrin gel provisional matrix that serves as the first step in stroma generation." @default.
- W2114125544 created "2016-06-24" @default.
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- W2114125544 date "2011-10-12" @default.
- W2114125544 modified "2023-10-14" @default.
- W2114125544 title "Vascular Hyperpermeability, Angiogenesis, and Stroma Generation" @default.
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- W2114125544 doi "https://doi.org/10.1101/cshperspect.a006544" @default.
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