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• W2114131567 endingPage "759" @default.
• W2114131567 startingPage "743" @default.
• W2114131567 abstract "Phage shock protein A (PspA) belongs to the highy conserved PspA/IM30 family and is a key component of the stress inducible Psp system in Escherichia coli. One of its central roles is the regulatory interaction with the transcriptional activator of this system, the σ(54) enhancer-binding protein PspF, a member of the AAA+ protein family. The PspA/F regulatory system has been intensively studied and serves as a paradigm for AAA+ enzyme regulation by trans-acting factors. However, the molecular mechanism of how exactly PspA controls the activity of PspF and hence σ(54) -dependent expression of the psp genes is still unclear. To approach this question, we identified the minimal PspF-interacting domain of PspA, solved its structure, determined its affinity to PspF and the dissociation kinetics, identified residues that are potentially important for PspF regulation and analyzed effects of their mutation on PspF in vivo and in vitro. Our data indicate that several characteristics of AAA+ regulation in the PspA·F complex resemble those of the AAA+ unfoldase ClpB, with both proteins being regulated by a structurally highly conserved coiled-coil domain. The convergent evolution of both regulatory domains points to a general mechanism to control AAA+ activity for divergent physiologic tasks via coiled-coil domains." @default.
• W2114131567 created "2016-06-24" @default.
• W2114131567 creator A5003446676 @default.
• W2114131567 creator A5019872414 @default.
• W2114131567 creator A5026100017 @default.
• W2114131567 creator A5045212144 @default.
• W2114131567 creator A5052825940 @default.
• W2114131567 creator A5059889901 @default.
• W2114131567 creator A5060985280 @default.
• W2114131567 creator A5066432463 @default.
• W2114131567 creator A5074351885 @default.
• W2114131567 creator A5084477612 @default.
• W2114131567 date "2015-09-10" @default.
• W2114131567 modified "2023-10-04" @default.
• W2114131567 title "PspF-binding domain PspA_1-144and the PspA·F complex: New insights into the coiled-coil-dependent regulation of AAA+ proteins" @default.
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