FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114133030> ?p ?o ?g. }

• W2114133030 endingPage "241" @default.
• W2114133030 startingPage "232" @default.
• W2114133030 abstract "Abstract Cells undergoing malignant transformation often exhibit a shift in cellular metabolism from oxidative phosphorylation to glycolysis. This glycolytic shift, called the Warburg effect, provides a mechanistic basis for targeting glycolysis to suppress carcinogenesis through the use of dietary caloric restriction and energy restriction-mimetic agents (ERMA). We recently reported the development of a novel class of ERMAs that exhibits high potency in eliciting starvation-associated cellular responses and epigenetic changes in cancer cells though glucose uptake inhibition. The lead ERMA in this class, OSU-CG5, decreases the production of ATP and NADH in LNCaP prostate cancer cells. In this study, we examined the effect of OSU-CG5 on the severity of preneoplastic lesions in male transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Daily oral treatment with OSU-CG5 at 100 mg/kg from 6 to 10 weeks of age resulted in a statistically significant decrease in the weight of urogenital tract and microdissected dorsal, lateral, and anterior prostatic lobes relative to vehicle controls. The suppressive effect of OSU-CG5 was evidenced by marked decreases in Ki67 immunostaining and proliferating cell nuclear antigen (PCNA) expression in the prostate. OSU-CG5 treatment was not associated with evidence of systemic toxicity. Microarray analysis indicated a central role for Akt, and Western blot analysis showed reduced phosphorylation and/or expression levels of Akt, Src, androgen receptor, and insulin-like growth factor-1 receptor in prostate lobes. These findings support further investigation of OSU-CG5 as a potential chemopreventive agent. Cancer Prev Res; 6(3); 232–41. ©2012 AACR." @default.
• W2114133030 created "2016-06-24" @default.
• W2114133030 creator A5011929463 @default.
• W2114133030 creator A5013392249 @default.
• W2114133030 creator A5030754741 @default.
• W2114133030 creator A5045074386 @default.
• W2114133030 creator A5056252373 @default.
• W2114133030 creator A5059929283 @default.
• W2114133030 creator A5061453297 @default.
• W2114133030 creator A5067139092 @default.
• W2114133030 creator A5074982960 @default.
• W2114133030 date "2013-03-01" @default.
• W2114133030 modified "2023-09-23" @default.
• W2114133030 title "Suppression of Prostate Epithelial Proliferation and Intraprostatic Progrowth Signaling in Transgenic Mice by a New Energy Restriction-Mimetic Agent" @default.
• W2114133030 cites W1991429659 @default.
• W2114133030 cites W1991685814 @default.
• W2114133030 cites W2009368851 @default.
• W2114133030 cites W2010057554 @default.
• W2114133030 cites W2014548867 @default.
• W2114133030 cites W2018212924 @default.
• W2114133030 cites W2019755500 @default.
• W2114133030 cites W2022101765 @default.
• W2114133030 cites W2022131162 @default.
• W2114133030 cites W2028505781 @default.
• W2114133030 cites W2033414387 @default.
• W2114133030 cites W2058648933 @default.
• W2114133030 cites W2063509147 @default.
• W2114133030 cites W2063646341 @default.
• W2114133030 cites W2068262029 @default.
• W2114133030 cites W2072451938 @default.
• W2114133030 cites W2084541894 @default.
• W2114133030 cites W2092787533 @default.
• W2114133030 cites W2096104754 @default.
• W2114133030 cites W2097259163 @default.
• W2114133030 cites W2102405465 @default.
• W2114133030 cites W2117072956 @default.
• W2114133030 cites W2119602224 @default.
• W2114133030 cites W2122291110 @default.
• W2114133030 cites W2123970190 @default.
• W2114133030 cites W2125840439 @default.
• W2114133030 cites W2130693972 @default.
• W2114133030 cites W2134253034 @default.
• W2114133030 cites W2140885702 @default.
• W2114133030 cites W2151493389 @default.
• W2114133030 cites W2157414760 @default.
• W2114133030 cites W2157820793 @default.
• W2114133030 cites W2158696397 @default.
• W2114133030 cites W2158955581 @default.
• W2114133030 cites W2322803810 @default.
• W2114133030 doi "https://doi.org/10.1158/1940-6207.capr-12-0057" @default.
• W2114133030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3835199" @default.
• W2114133030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23275006" @default.
• W2114133030 hasPublicationYear "2013" @default.
• W2114133030 type Work @default.
• W2114133030 sameAs 2114133030 @default.
• W2114133030 citedByCount "11" @default.
• W2114133030 countsByYear W21141330302013 @default.
• W2114133030 countsByYear W21141330302014 @default.
• W2114133030 countsByYear W21141330302015 @default.
• W2114133030 countsByYear W21141330302020 @default.
• W2114133030 crossrefType "journal-article" @default.
• W2114133030 hasAuthorship W2114133030A5011929463 @default.
• W2114133030 hasAuthorship W2114133030A5013392249 @default.
• W2114133030 hasAuthorship W2114133030A5030754741 @default.
• W2114133030 hasAuthorship W2114133030A5045074386 @default.
• W2114133030 hasAuthorship W2114133030A5056252373 @default.
• W2114133030 hasAuthorship W2114133030A5059929283 @default.
• W2114133030 hasAuthorship W2114133030A5061453297 @default.
• W2114133030 hasAuthorship W2114133030A5067139092 @default.
• W2114133030 hasAuthorship W2114133030A5074982960 @default.
• W2114133030 hasBestOaLocation W21141330301 @default.
• W2114133030 hasConcept C121608353 @default.
• W2114133030 hasConcept C126322002 @default.
• W2114133030 hasConcept C134018914 @default.
• W2114133030 hasConcept C2776235491 @default.
• W2114133030 hasConcept C2777609662 @default.
• W2114133030 hasConcept C2779723316 @default.
• W2114133030 hasConcept C2780192828 @default.
• W2114133030 hasConcept C2780940892 @default.
• W2114133030 hasConcept C502942594 @default.
• W2114133030 hasConcept C555283112 @default.
• W2114133030 hasConcept C62478195 @default.
• W2114133030 hasConcept C71924100 @default.
• W2114133030 hasConcept C75217442 @default.
• W2114133030 hasConcept C86554907 @default.
• W2114133030 hasConcept C86803240 @default.
• W2114133030 hasConcept C95444343 @default.
• W2114133030 hasConceptScore W2114133030C121608353 @default.
• W2114133030 hasConceptScore W2114133030C126322002 @default.
• W2114133030 hasConceptScore W2114133030C134018914 @default.
• W2114133030 hasConceptScore W2114133030C2776235491 @default.
• W2114133030 hasConceptScore W2114133030C2777609662 @default.
• W2114133030 hasConceptScore W2114133030C2779723316 @default.
• W2114133030 hasConceptScore W2114133030C2780192828 @default.
• W2114133030 hasConceptScore W2114133030C2780940892 @default.
• W2114133030 hasConceptScore W2114133030C502942594 @default.
• W2114133030 hasConceptScore W2114133030C555283112 @default.
• W2114133030 hasConceptScore W2114133030C62478195 @default.

• next