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- W2114134119 abstract "Recent studies have provided evidence for non-canonical imprinting effects that are associated with allele-specific expression biases at the tissue level in mice. These imprinting effects have features that are distinct from canonical imprinting effects that involve allele silencing. Here, I discuss some of the evidence for non-canonical imprinting effects in the context of random X-inactivation and epigenetic allele-specific expression effects on the autosomes. I propose several mechanisms that may underlie non-canonical imprinting effects and outline future directions and approaches to study these effects at the cellular level in vivo. The growing evidence for complex allele-specific expression effects that are cell- and developmental stage-specific has opened a new frontier for study. Currently, the function of these effects and the underlying regulatory mechanisms are largely unknown." @default.
- W2114134119 created "2016-06-24" @default.
- W2114134119 creator A5000831778 @default.
- W2114134119 date "2014-09-04" @default.
- W2114134119 modified "2023-09-25" @default.
- W2114134119 title "Known unknowns for allele-specific expression and genomic imprinting effects" @default.
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- W2114134119 doi "https://doi.org/10.12703/p6-75" @default.
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