FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114163372> ?p ?o ?g. }

• W2114163372 endingPage "257" @default.
• W2114163372 startingPage "249" @default.
• W2114163372 abstract "Chemokines were shown to govern the trafficking of immune cells and may also play important roles in the survival and activation of these cells. We report here that under physiological conditions, the bone marrow (BM), spleen, blood and liver of Ccr5, but not of Ccr1-deficient mice, contain reduced numbers of NK cells. NK cells in the BM of Ccr5-deficient mice proliferate to a lesser extent compared to WT mice. Furthermore, spleen NK cells derived from Ccr5-deficient mice that were transplanted into irradiated recipients failed to proliferate in the host. Ccr5, but not Ccr1-deficient NK cells, failed to migrate in vitro in response to RANTES and MIP-1β but not MIP-1β or SDF-1 and had reduced activation, lower expression levels of NK cell markers and a slightly reduced capacity to adhere to target cells and stimulate their killing. Using the polyI:C mouse model for NK trafficking, we found that in the absence of Ccr5, but not Ccr1, NK cells failed to accumulate in the liver. In contrast, using the influenza viral infection as a model to evaluate NK cell proliferation, we found that Ccr5-deficient NK cells in the BM had a higher proliferation rate than WT NK cells. These results suggest a role for Ccr5 in NK cell proliferation and circulation under physiological conditions and a complex role for Ccr5 in determining the fate of NK cells under pathological conditions." @default.
• W2114163372 created "2016-06-24" @default.
• W2114163372 creator A5014494339 @default.
• W2114163372 creator A5027697717 @default.
• W2114163372 creator A5054164689 @default.
• W2114163372 creator A5058925624 @default.
• W2114163372 creator A5060037363 @default.
• W2114163372 creator A5062667726 @default.
• W2114163372 creator A5072991940 @default.
• W2114163372 creator A5075688675 @default.
• W2114163372 creator A5078781359 @default.
• W2114163372 creator A5090206769 @default.
• W2114163372 date "2011-06-01" @default.
• W2114163372 modified "2023-10-16" @default.
• W2114163372 title "Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions" @default.
• W2114163372 cites W1501500713 @default.
• W2114163372 cites W1534709281 @default.
• W2114163372 cites W1580179014 @default.
• W2114163372 cites W1914256230 @default.
• W2114163372 cites W1944461161 @default.
• W2114163372 cites W1964742561 @default.
• W2114163372 cites W1976620258 @default.
• W2114163372 cites W1980307352 @default.
• W2114163372 cites W1980349196 @default.
• W2114163372 cites W1984051873 @default.
• W2114163372 cites W1984704941 @default.
• W2114163372 cites W2001793164 @default.
• W2114163372 cites W2009342562 @default.
• W2114163372 cites W2015785347 @default.
• W2114163372 cites W2017162467 @default.
• W2114163372 cites W2019061269 @default.
• W2114163372 cites W2029129294 @default.
• W2114163372 cites W2043246373 @default.
• W2114163372 cites W2043851305 @default.
• W2114163372 cites W2049059614 @default.
• W2114163372 cites W2063591664 @default.
• W2114163372 cites W2070835609 @default.
• W2114163372 cites W2073244735 @default.
• W2114163372 cites W2078811876 @default.
• W2114163372 cites W2089684997 @default.
• W2114163372 cites W2096449627 @default.
• W2114163372 cites W2101208385 @default.
• W2114163372 cites W2103178838 @default.
• W2114163372 cites W2105489252 @default.
• W2114163372 cites W2111876649 @default.
• W2114163372 cites W2120996101 @default.
• W2114163372 cites W2125163646 @default.
• W2114163372 cites W2135279391 @default.
• W2114163372 cites W2143576416 @default.
• W2114163372 cites W2146778105 @default.
• W2114163372 cites W2151751317 @default.
• W2114163372 cites W2162620968 @default.
• W2114163372 cites W2170739757 @default.
• W2114163372 cites W4243023915 @default.
• W2114163372 doi "https://doi.org/10.1016/j.cyto.2011.01.011" @default.
• W2114163372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21376626" @default.
• W2114163372 hasPublicationYear "2011" @default.
• W2114163372 type Work @default.
• W2114163372 sameAs 2114163372 @default.
• W2114163372 citedByCount "27" @default.
• W2114163372 countsByYear W21141633722012 @default.
• W2114163372 countsByYear W21141633722013 @default.
• W2114163372 countsByYear W21141633722014 @default.
• W2114163372 countsByYear W21141633722015 @default.
• W2114163372 countsByYear W21141633722016 @default.
• W2114163372 countsByYear W21141633722017 @default.
• W2114163372 countsByYear W21141633722018 @default.
• W2114163372 countsByYear W21141633722019 @default.
• W2114163372 countsByYear W21141633722020 @default.
• W2114163372 countsByYear W21141633722021 @default.
• W2114163372 countsByYear W21141633722022 @default.
• W2114163372 crossrefType "journal-article" @default.
• W2114163372 hasAuthorship W2114163372A5014494339 @default.
• W2114163372 hasAuthorship W2114163372A5027697717 @default.
• W2114163372 hasAuthorship W2114163372A5054164689 @default.
• W2114163372 hasAuthorship W2114163372A5058925624 @default.
• W2114163372 hasAuthorship W2114163372A5060037363 @default.
• W2114163372 hasAuthorship W2114163372A5062667726 @default.
• W2114163372 hasAuthorship W2114163372A5072991940 @default.
• W2114163372 hasAuthorship W2114163372A5075688675 @default.
• W2114163372 hasAuthorship W2114163372A5078781359 @default.
• W2114163372 hasAuthorship W2114163372A5090206769 @default.
• W2114163372 hasConcept C12823836 @default.
• W2114163372 hasConcept C129013479 @default.
• W2114163372 hasConcept C129374314 @default.
• W2114163372 hasConcept C13373296 @default.
• W2114163372 hasConcept C149532602 @default.
• W2114163372 hasConcept C154317977 @default.
• W2114163372 hasConcept C202751555 @default.
• W2114163372 hasConcept C203014093 @default.
• W2114163372 hasConcept C2776090121 @default.
• W2114163372 hasConcept C2780007613 @default.
• W2114163372 hasConcept C2780931953 @default.
• W2114163372 hasConcept C45635710 @default.
• W2114163372 hasConcept C55493867 @default.
• W2114163372 hasConcept C86803240 @default.
• W2114163372 hasConcept C8891405 @default.
• W2114163372 hasConcept C95444343 @default.

• next