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- W2114171774 abstract "The role of the noradrenergic system in quasi-morphine abstinence behaviour induced by di-n-propylacetate (DPA) in rats has been studied. Depletion of noradrenaline (NA), by treatment with FLA-63, decreased the number of body shakes and the extent of horizontal activity evoked by DPA. Almost total suppression of these symptoms was obtained by injection of 20 ng morphine bilaterally into the locus coeruleus (LC). Destruction of the LC system by electrolytic lesion of the LC or by injection of 6-hyrodroxy-dopamine into the dorsal bundle revealed that degeneration of the NA system by at least 80% appears to be necessary to decrease the number of body shakes. It is concluded that the noradrenergic LC system fulfills a modulatory role in quasi-morphine abstinence behaviour induced by DPA." @default.
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- W2114171774 date "1982-09-01" @default.
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- W2114171774 title "Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Participation of the locus coeruleus system" @default.
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- W2114171774 doi "https://doi.org/10.1016/0006-8993(82)91255-0" @default.
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