FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114190147> ?p ?o ?g. }

• W2114190147 abstract "Abstract Background Remission of multiple sclerosis during periods of high ovarian hormone secretion (such as pregnancy) has led to a great deal of interest in the potential for estrogens to treat autoimmune disease. Previous work has established that 17β-estradiol can inhibit onset of experimental autoimmune encephalomyelitis (EAE), while ethinyl estradiol (EE) can reduce the severity of established disease. In the current study, the influence of estrogen receptor-α (ERα) and the G-protein coupled estrogen receptor (GPR30 or GPER) on EE's ability to treat EAE was explored. Results EE reduced disease severity in wild-type and ERα knockout (ERKO) mice, but did not alter disease in the GPR30KO group. Production of anti-inflammatory IL-10 increased in EE-ERKO mice (which showed reduced disease) but not in EE-GPR30KO mice (who did not have improved disease). Conclusions Differential production of IL-10 following EE treatment in ERKO and GPR30KO animals may be responsible for the distinctly different effects on disease severity. Increased IL-10 in ERKO-EE compared to ERKO-Controls is likely to be an important factor in reducing established disease. The inability of EE to reduce disease in GPR30KO mice indicates an important but still undefined role for GPR30 in regulating immune reactivity." @default.
• W2114190147 created "2016-06-24" @default.
• W2114190147 creator A5000848787 @default.
• W2114190147 creator A5005092225 @default.
• W2114190147 creator A5027761713 @default.
• W2114190147 creator A5087867695 @default.
• W2114190147 date "2010-04-19" @default.
• W2114190147 modified "2023-10-06" @default.
• W2114190147 title "GPR30, but not estrogen receptor-α, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol" @default.
• W2114190147 cites W1512229668 @default.
• W2114190147 cites W1519566824 @default.
• W2114190147 cites W1531784929 @default.
• W2114190147 cites W1928494949 @default.
• W2114190147 cites W1967825074 @default.
• W2114190147 cites W1979898922 @default.
• W2114190147 cites W2004361944 @default.
• W2114190147 cites W2022072580 @default.
• W2114190147 cites W2025531932 @default.
• W2114190147 cites W2035868659 @default.
• W2114190147 cites W2042197302 @default.
• W2114190147 cites W2054568941 @default.
• W2114190147 cites W2060089716 @default.
• W2114190147 cites W2086539844 @default.
• W2114190147 cites W2088783992 @default.
• W2114190147 cites W2108806659 @default.
• W2114190147 cites W2113836432 @default.
• W2114190147 cites W2131958114 @default.
• W2114190147 cites W2138622901 @default.
• W2114190147 cites W2141269411 @default.
• W2114190147 cites W2157275878 @default.
• W2114190147 cites W2159203244 @default.
• W2114190147 cites W2319459971 @default.
• W2114190147 doi "https://doi.org/10.1186/1471-2172-11-20" @default.
• W2114190147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2864220" @default.
• W2114190147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20403194" @default.
• W2114190147 hasPublicationYear "2010" @default.
• W2114190147 type Work @default.
• W2114190147 sameAs 2114190147 @default.
• W2114190147 citedByCount "65" @default.
• W2114190147 countsByYear W21141901472012 @default.
• W2114190147 countsByYear W21141901472013 @default.
• W2114190147 countsByYear W21141901472014 @default.
• W2114190147 countsByYear W21141901472015 @default.
• W2114190147 countsByYear W21141901472016 @default.
• W2114190147 countsByYear W21141901472017 @default.
• W2114190147 countsByYear W21141901472018 @default.
• W2114190147 countsByYear W21141901472019 @default.
• W2114190147 countsByYear W21141901472020 @default.
• W2114190147 countsByYear W21141901472021 @default.
• W2114190147 countsByYear W21141901472022 @default.
• W2114190147 countsByYear W21141901472023 @default.
• W2114190147 crossrefType "journal-article" @default.
• W2114190147 hasAuthorship W2114190147A5000848787 @default.
• W2114190147 hasAuthorship W2114190147A5005092225 @default.
• W2114190147 hasAuthorship W2114190147A5027761713 @default.
• W2114190147 hasAuthorship W2114190147A5087867695 @default.
• W2114190147 hasBestOaLocation W21141901471 @default.
• W2114190147 hasConcept C121608353 @default.
• W2114190147 hasConcept C126322002 @default.
• W2114190147 hasConcept C134018914 @default.
• W2114190147 hasConcept C166471694 @default.
• W2114190147 hasConcept C203014093 @default.
• W2114190147 hasConcept C2777164284 @default.
• W2114190147 hasConcept C2778486448 @default.
• W2114190147 hasConcept C2779075594 @default.
• W2114190147 hasConcept C2779134260 @default.
• W2114190147 hasConcept C2780640218 @default.
• W2114190147 hasConcept C530470458 @default.
• W2114190147 hasConcept C71924100 @default.
• W2114190147 hasConcept C84606932 @default.
• W2114190147 hasConcept C8891405 @default.
• W2114190147 hasConceptScore W2114190147C121608353 @default.
• W2114190147 hasConceptScore W2114190147C126322002 @default.
• W2114190147 hasConceptScore W2114190147C134018914 @default.
• W2114190147 hasConceptScore W2114190147C166471694 @default.
• W2114190147 hasConceptScore W2114190147C203014093 @default.
• W2114190147 hasConceptScore W2114190147C2777164284 @default.
• W2114190147 hasConceptScore W2114190147C2778486448 @default.
• W2114190147 hasConceptScore W2114190147C2779075594 @default.
• W2114190147 hasConceptScore W2114190147C2779134260 @default.
• W2114190147 hasConceptScore W2114190147C2780640218 @default.
• W2114190147 hasConceptScore W2114190147C530470458 @default.
• W2114190147 hasConceptScore W2114190147C71924100 @default.
• W2114190147 hasConceptScore W2114190147C84606932 @default.
• W2114190147 hasConceptScore W2114190147C8891405 @default.
• W2114190147 hasIssue "1" @default.
• W2114190147 hasLocation W21141901471 @default.
• W2114190147 hasLocation W21141901472 @default.
• W2114190147 hasLocation W21141901473 @default.
• W2114190147 hasLocation W21141901474 @default.
• W2114190147 hasLocation W21141901475 @default.
• W2114190147 hasOpenAccess W2114190147 @default.
• W2114190147 hasPrimaryLocation W21141901471 @default.
• W2114190147 hasRelatedWork W1712028553 @default.
• W2114190147 hasRelatedWork W1992293805 @default.
• W2114190147 hasRelatedWork W2068408721 @default.
• W2114190147 hasRelatedWork W2093476509 @default.
• W2114190147 hasRelatedWork W2101821182 @default.
• W2114190147 hasRelatedWork W2109882125 @default.
• W2114190147 hasRelatedWork W2150216118 @default.

• next