FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114197748> ?p ?o ?g. }

• W2114197748 endingPage "201" @default.
• W2114197748 startingPage "194" @default.
• W2114197748 abstract "Stiff-man syndrome (SMS) is a rare disorder of the central nervous system thought to result from an impairment of γ-aminobutyric acid (GABA)ergic neurotransmission. Autoantibodies to the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD), present in about 60% of SMS patients, have suggested an autoimmune pathogenesis of SMS. By using serum or cerebrospinal fluid from 25 SMS patients, we assessed the effect of GAD autoantibodies (GAD-A) on GAD enzymatic activity in vitro; 83% of GAD-A–positive SMS sera reduced GABA production in crude rat cerebellar extracts, whereas GAD-A− sera from SMS patients or healthy blood donors did not alter the enzyme activity. Inhibition of GABA synthesis by SMS sera was dose dependent and mediated by the purified IgG fraction of the sera. Human monoclonal GAD65-A and IgG purified from serum of GAD-A–positive patients with insulin-dependent diabetes or autoimmune polyendocrine syndrome did not effect GAD activity, suggesting that a specific epitope recognition of GAD-A mediates inhibition of GAD. The disease-specific detection of GAD-inhibitory antibodies is compatible with their functional involvement in the etiopathology of SMS; the relevance of such antibodies in vivo, however, remains to be determined." @default.
• W2114197748 created "2016-06-24" @default.
• W2114197748 creator A5028355843 @default.
• W2114197748 creator A5035620085 @default.
• W2114197748 creator A5050017885 @default.
• W2114197748 creator A5062153453 @default.
• W2114197748 creator A5087571933 @default.
• W2114197748 date "1998-08-01" @default.
• W2114197748 modified "2023-10-16" @default.
• W2114197748 title "Inhibition of ?-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome" @default.
• W2114197748 cites W1661585222 @default.
• W2114197748 cites W1978885851 @default.
• W2114197748 cites W1987913280 @default.
• W2114197748 cites W1989593817 @default.
• W2114197748 cites W1993398185 @default.
• W2114197748 cites W1995687031 @default.
• W2114197748 cites W1997222580 @default.
• W2114197748 cites W1998735846 @default.
• W2114197748 cites W2026959935 @default.
• W2114197748 cites W2029863714 @default.
• W2114197748 cites W2033833022 @default.
• W2114197748 cites W2039596527 @default.
• W2114197748 cites W2059076391 @default.
• W2114197748 cites W2072652145 @default.
• W2114197748 cites W2075290922 @default.
• W2114197748 cites W2081293878 @default.
• W2114197748 cites W2083873191 @default.
• W2114197748 cites W2097692330 @default.
• W2114197748 cites W2104960492 @default.
• W2114197748 cites W2109997219 @default.
• W2114197748 cites W2127744525 @default.
• W2114197748 cites W2161020257 @default.
• W2114197748 cites W2165301894 @default.
• W2114197748 cites W2167340154 @default.
• W2114197748 cites W2170684107 @default.
• W2114197748 cites W2327060038 @default.
• W2114197748 cites W2341009442 @default.
• W2114197748 doi "https://doi.org/10.1002/ana.410440209" @default.
• W2114197748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9708541" @default.
• W2114197748 hasPublicationYear "1998" @default.
• W2114197748 type Work @default.
• W2114197748 sameAs 2114197748 @default.
• W2114197748 citedByCount "208" @default.
• W2114197748 countsByYear W21141977482012 @default.
• W2114197748 countsByYear W21141977482013 @default.
• W2114197748 countsByYear W21141977482014 @default.
• W2114197748 countsByYear W21141977482015 @default.
• W2114197748 countsByYear W21141977482016 @default.
• W2114197748 countsByYear W21141977482017 @default.
• W2114197748 countsByYear W21141977482018 @default.
• W2114197748 countsByYear W21141977482019 @default.
• W2114197748 countsByYear W21141977482020 @default.
• W2114197748 countsByYear W21141977482021 @default.
• W2114197748 countsByYear W21141977482022 @default.
• W2114197748 countsByYear W21141977482023 @default.
• W2114197748 crossrefType "journal-article" @default.
• W2114197748 hasAuthorship W2114197748A5028355843 @default.
• W2114197748 hasAuthorship W2114197748A5035620085 @default.
• W2114197748 hasAuthorship W2114197748A5050017885 @default.
• W2114197748 hasAuthorship W2114197748A5062153453 @default.
• W2114197748 hasAuthorship W2114197748A5087571933 @default.
• W2114197748 hasConcept C126322002 @default.
• W2114197748 hasConcept C134018914 @default.
• W2114197748 hasConcept C150903083 @default.
• W2114197748 hasConcept C159654299 @default.
• W2114197748 hasConcept C163764329 @default.
• W2114197748 hasConcept C17077164 @default.
• W2114197748 hasConcept C181199279 @default.
• W2114197748 hasConcept C185592680 @default.
• W2114197748 hasConcept C195616568 @default.
• W2114197748 hasConcept C203014093 @default.
• W2114197748 hasConcept C207001950 @default.
• W2114197748 hasConcept C2776443654 @default.
• W2114197748 hasConcept C2779177108 @default.
• W2114197748 hasConcept C2780627266 @default.
• W2114197748 hasConcept C542903549 @default.
• W2114197748 hasConcept C55493867 @default.
• W2114197748 hasConcept C71924100 @default.
• W2114197748 hasConcept C86803240 @default.
• W2114197748 hasConcept C9497952 @default.
• W2114197748 hasConceptScore W2114197748C126322002 @default.
• W2114197748 hasConceptScore W2114197748C134018914 @default.
• W2114197748 hasConceptScore W2114197748C150903083 @default.
• W2114197748 hasConceptScore W2114197748C159654299 @default.
• W2114197748 hasConceptScore W2114197748C163764329 @default.
• W2114197748 hasConceptScore W2114197748C17077164 @default.
• W2114197748 hasConceptScore W2114197748C181199279 @default.
• W2114197748 hasConceptScore W2114197748C185592680 @default.
• W2114197748 hasConceptScore W2114197748C195616568 @default.
• W2114197748 hasConceptScore W2114197748C203014093 @default.
• W2114197748 hasConceptScore W2114197748C207001950 @default.
• W2114197748 hasConceptScore W2114197748C2776443654 @default.
• W2114197748 hasConceptScore W2114197748C2779177108 @default.
• W2114197748 hasConceptScore W2114197748C2780627266 @default.
• W2114197748 hasConceptScore W2114197748C542903549 @default.
• W2114197748 hasConceptScore W2114197748C55493867 @default.
• W2114197748 hasConceptScore W2114197748C71924100 @default.
• W2114197748 hasConceptScore W2114197748C86803240 @default.

• next