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- W2114202267 abstract "Elucidation of protective mechanisms against ischemia-reperfusion injury is vital to the advancement of therapeutics for ischemic heart disease. Our laboratory has previously shown that cardiac-specific overexpression of fibroblast growth factor-2 (FGF2) results in increased recovery of contractile function and decreased infarct size following ischemia-reperfusion injury and has established a role for the mitogen-activated protein kinase (MAPK) signaling cascade in the cardioprotective effect of FGF2. We now show an additional role for the protein kinase C (PKC) signaling cascade in the mediation of FGF2-induced cardioprotection. Overexpression of FGF2 ( FGF2 Tg) in the heart resulted in decreased translocation of PKC-δ but had no effect on PKC-α, -ε, or -ζ. In addition, multiple alterations in PKC isoform translocation occur during ischemia-reperfusion injury in FGF2 Tg hearts as assessed by Western blot analysis and confocal immunofluorescent microscopy. Treatment of FGF2 Tg and nontransgenic (NTg) hearts with the PKC inhibitor bisindolylmaleimide (1 μmol/l) revealed the necessity of PKC signaling for FGF2-induced reduction of contractile dysfunction and myocardial infarct size following ischemia-reperfusion injury. Western blot analysis of FGF2 Tg and NTg hearts subjected to ischemia-reperfusion injury in the presence of a PKC pathway inhibitor (bisindolylmaleimide, 1 μmol/l), an mitogen/extracellular signal-regulated kinase/extracellular signal-regulated kinase (MEK/ERK) pathway inhibitor (U-0126, 2.5 μmol/l), or a p38 pathway inhibitor (SB-203580, 2 μmol/l) revealed a complicated signaling network between the PKC and MAPK signaling cascades that may participate in FGF2-induced cardioprotection. Together, these data suggest that FGF2-induced cardioprotection is mediated via a PKC-dependent pathway and that the PKC and MAPK signaling cascades are integrally connected downstream of FGF2." @default.
- W2114202267 created "2016-06-24" @default.
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- W2114202267 date "2007-07-01" @default.
- W2114202267 modified "2023-09-23" @default.
- W2114202267 title "The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2" @default.
- W2114202267 cites W125482507 @default.
- W2114202267 cites W1481175 @default.
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- W2114202267 cites W1517887854 @default.
- W2114202267 cites W1586155899 @default.
- W2114202267 cites W1597893467 @default.
- W2114202267 cites W1602807836 @default.
- W2114202267 cites W1641731911 @default.
- W2114202267 cites W1755902553 @default.
- W2114202267 cites W1767727568 @default.
- W2114202267 cites W1806836340 @default.
- W2114202267 cites W1963970071 @default.
- W2114202267 cites W1964646716 @default.
- W2114202267 cites W1967526945 @default.
- W2114202267 cites W1973005880 @default.
- W2114202267 cites W1974635628 @default.
- W2114202267 cites W1981527120 @default.
- W2114202267 cites W1993160438 @default.
- W2114202267 cites W1995493673 @default.
- W2114202267 cites W2018133517 @default.
- W2114202267 cites W201874790 @default.
- W2114202267 cites W2022546498 @default.
- W2114202267 cites W2023224518 @default.
- W2114202267 cites W2023494473 @default.
- W2114202267 cites W2026750322 @default.
- W2114202267 cites W2028565349 @default.
- W2114202267 cites W2032144305 @default.
- W2114202267 cites W2036628331 @default.
- W2114202267 cites W2046525768 @default.
- W2114202267 cites W2048832222 @default.
- W2114202267 cites W2061052988 @default.
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- W2114202267 cites W2072564164 @default.
- W2114202267 cites W2072939316 @default.
- W2114202267 cites W2074190381 @default.
- W2114202267 cites W2074301028 @default.
- W2114202267 cites W2075898803 @default.
- W2114202267 cites W2077041439 @default.
- W2114202267 cites W2077172545 @default.
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- W2114202267 cites W2095661018 @default.
- W2114202267 cites W2106727226 @default.
- W2114202267 cites W2109283410 @default.
- W2114202267 cites W2116286593 @default.
- W2114202267 cites W2119537724 @default.
- W2114202267 cites W2120689455 @default.
- W2114202267 cites W2126241200 @default.
- W2114202267 cites W2127322949 @default.
- W2114202267 cites W2129742695 @default.
- W2114202267 cites W2134643192 @default.
- W2114202267 cites W2138812267 @default.
- W2114202267 cites W2139834613 @default.
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- W2114202267 cites W2146989813 @default.
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- W2114202267 cites W2165779745 @default.
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- W2114202267 doi "https://doi.org/10.1152/ajpheart.00804.2006" @default.
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- W2114202267 hasPublicationYear "2007" @default.
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