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• W2114208892 abstract "In vitro culture of human thymocytes resulted in the development of cells with natural killer (NK) activity and the acquisition of a pan-NK antigen (NKH1) by a large number of thymocytes. The ability to kill the NK-sensitive target, K562, was restricted to thymocytes expressing the NKH1 antigen. All NKH1+ thymocytes displayed a mature T cell phenotype, T3+T11+T8+T4−. Both the acquisition of NK activity and the development of cells with the NKH1+ phenotype could be suppressed by culturing thymocytes in the presence of adherent mononuclear cells. These results suggest that adherent accessory cells have the ability to regulate the development of T cell lineage NK cells." @default.
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• W2114208892 date "1987-01-01" @default.
• W2114208892 modified "2023-09-23" @default.
• W2114208892 title "Development of natural killer cells in human thymocyte culture: regulation by accessory cells" @default.
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• W2114208892 doi "https://doi.org/10.1002/eji.1830170514" @default.
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