FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114212659> ?p ?o ?g. }

• W2114212659 endingPage "561" @default.
• W2114212659 startingPage "554" @default.
• W2114212659 abstract "The mechanism by which viruses cause exacerbations of chronic airway disease and the capacity of patients with cystic fibrosis (CF) to respond to viral infection are not precisely known.To determine the antiviral response to infection in patients with CF.Sputum was collected from patients with CF with respiratory exacerbation. Viruses were detected in multiplex polymerase chain reaction (PCR)-based assays. Gene expression of 84 antiviral response genes was measured, using a focused quantitative PCR gene array.We examined 36 samples from 23 patients with respiratory exacerbation. Fourteen samples tested virus-positive and 22 virus-negative. When we compared exacerbations associated with rhinovirus (RV, n = 9) and influenza (n = 5) with virus-negative specimens, we found distinct patterns of antiviral gene expression. RV was associated with greater than twofold induction of five genes, including those encoding the monocyte-attracting chemokines CXCL10, CXCL11, and CXCL9. Influenza was associated with overexpression of 20 genes, including those encoding the cytokines tumor necrosis factor and IL-12; the kinases MEK, TBK-1, and STAT-1; the apoptosis proteins caspase-8 and caspase-10; the influenza double-stranded RNA receptor RIG-I and its downstream effector MAVS; and pyrin, an IFN-stimulated protein involved in influenza resistance.We conclude that virus-induced exacerbations of CF are associated with immune responses tailored to specific infections. Influenza induced a more potent response consisting of inflammation, whereas RV infection had a pronounced effect on chemokine expression. As far as we are aware, this study is the first to compare specific responses to different viruses in live patients with chronic airway disease." @default.
• W2114212659 created "2016-06-24" @default.
• W2114212659 creator A5010161867 @default.
• W2114212659 creator A5027613904 @default.
• W2114212659 creator A5030739703 @default.
• W2114212659 creator A5036421485 @default.
• W2114212659 creator A5040845006 @default.
• W2114212659 creator A5042719032 @default.
• W2114212659 creator A5054089917 @default.
• W2114212659 creator A5081647219 @default.
• W2114212659 creator A5089178683 @default.
• W2114212659 date "2014-05-01" @default.
• W2114212659 modified "2023-10-14" @default.
• W2114212659 title "Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis" @default.
• W2114212659 cites W1521277996 @default.
• W2114212659 cites W1940414999 @default.
• W2114212659 cites W1974189255 @default.
• W2114212659 cites W1984870545 @default.
• W2114212659 cites W1990323340 @default.
• W2114212659 cites W2001636316 @default.
• W2114212659 cites W2004817354 @default.
• W2114212659 cites W2016675332 @default.
• W2114212659 cites W2025877008 @default.
• W2114212659 cites W2038044678 @default.
• W2114212659 cites W2041669657 @default.
• W2114212659 cites W2048053168 @default.
• W2114212659 cites W2048204433 @default.
• W2114212659 cites W2051149320 @default.
• W2114212659 cites W2056291443 @default.
• W2114212659 cites W2057089799 @default.
• W2114212659 cites W2062368346 @default.
• W2114212659 cites W2067374081 @default.
• W2114212659 cites W2067706259 @default.
• W2114212659 cites W2072498692 @default.
• W2114212659 cites W2073463392 @default.
• W2114212659 cites W2075009759 @default.
• W2114212659 cites W2075282927 @default.
• W2114212659 cites W2075427110 @default.
• W2114212659 cites W2076700294 @default.
• W2114212659 cites W2079096997 @default.
• W2114212659 cites W2094167812 @default.
• W2114212659 cites W2099542884 @default.
• W2114212659 cites W2099595302 @default.
• W2114212659 cites W2100861375 @default.
• W2114212659 cites W2104774207 @default.
• W2114212659 cites W2107286925 @default.
• W2114212659 cites W2110067513 @default.
• W2114212659 cites W2110599341 @default.
• W2114212659 cites W2119972555 @default.
• W2114212659 cites W2122010894 @default.
• W2114212659 cites W2126205901 @default.
• W2114212659 cites W2132942986 @default.
• W2114212659 cites W2134478496 @default.
• W2114212659 cites W2136054419 @default.
• W2114212659 cites W2138192279 @default.
• W2114212659 cites W2138802389 @default.
• W2114212659 cites W2141109742 @default.
• W2114212659 cites W2151989284 @default.
• W2114212659 cites W2152350894 @default.
• W2114212659 cites W2163982249 @default.
• W2114212659 cites W2165612110 @default.
• W2114212659 cites W2167324457 @default.
• W2114212659 cites W2172082722 @default.
• W2114212659 cites W2337822896 @default.
• W2114212659 doi "https://doi.org/10.1513/annalsats.201310-346oc" @default.
• W2114212659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4225796" @default.
• W2114212659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24641803" @default.
• W2114212659 hasPublicationYear "2014" @default.
• W2114212659 type Work @default.
• W2114212659 sameAs 2114212659 @default.
• W2114212659 citedByCount "25" @default.
• W2114212659 countsByYear W21142126592014 @default.
• W2114212659 countsByYear W21142126592015 @default.
• W2114212659 countsByYear W21142126592016 @default.
• W2114212659 countsByYear W21142126592017 @default.
• W2114212659 countsByYear W21142126592018 @default.
• W2114212659 countsByYear W21142126592020 @default.
• W2114212659 countsByYear W21142126592022 @default.
• W2114212659 countsByYear W21142126592023 @default.
• W2114212659 crossrefType "journal-article" @default.
• W2114212659 hasAuthorship W2114212659A5010161867 @default.
• W2114212659 hasAuthorship W2114212659A5027613904 @default.
• W2114212659 hasAuthorship W2114212659A5030739703 @default.
• W2114212659 hasAuthorship W2114212659A5036421485 @default.
• W2114212659 hasAuthorship W2114212659A5040845006 @default.
• W2114212659 hasAuthorship W2114212659A5042719032 @default.
• W2114212659 hasAuthorship W2114212659A5054089917 @default.
• W2114212659 hasAuthorship W2114212659A5081647219 @default.
• W2114212659 hasAuthorship W2114212659A5089178683 @default.
• W2114212659 hasBestOaLocation W21142126592 @default.
• W2114212659 hasConcept C126322002 @default.
• W2114212659 hasConcept C13373296 @default.
• W2114212659 hasConcept C159047783 @default.
• W2114212659 hasConcept C17502307 @default.
• W2114212659 hasConcept C203014093 @default.
• W2114212659 hasConcept C2522874641 @default.
• W2114212659 hasConcept C2776938444 @default.
• W2114212659 hasConcept C2777546802 @default.

• next