FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114215087> ?p ?o ?g. }

• W2114215087 endingPage "62" @default.
• W2114215087 startingPage "58" @default.
• W2114215087 abstract "In this pro-con debate, we will analyse the relevance of data supporting the prime role of uraemic toxins versus salt and volume overload as the main driver for the impressive mortality and morbidity characteristic of any end-stage re- nal disease patient. Firstly, we are going to review the circumstantial evidence and associated studies/clinical observational data which only weakly suggest that uraemic solutes are indeed linked to damage to the body and its constituents, especially the car- diovascular (CV) system. At the same time, we will equally thoroughly discuss the 'fact' that decreasing salt and fluid load is essential for any dialysed patient. Evidence in favour of a prominent role for uraemic toxins is appealing from a pathophysiological point of view, but unfortunately is mis- leading in real life practice. Evidence in favour of salt and water reduction is overwhelmingly stronger. This difference in apparent evidence strength notwith- standing the weaker support for uraemic toxins does not take away from clinical importance of minimizing uraemic tox- icity load in the large majority of the dialysis population. filtration (HDF) or more frequent/longer dialysis, was only partially associated with better results. Moreover, in the ma- jority of the positive studies, alternative interpretations of the results is possible, including a contribution of better volume control achievable with these particular dialysis techniques. Some 'observational' studies (2-7) showed a beneficial effect of high-flux versus low-flux synthetic dialysis mem- branes on survival, whereas prospective random controlled trials (RCTs) were inconclusive. In the Haemodialysis (HEMO) study, the largest random- ized clinical trial conducted in haemodialysis (HD) so far, patients were randomized to either a high-dialysis dose (achieved eKt/V ¼ 1.53 � 0.09, sp Kt/V ¼ 1.71 � 0.11) or a standard-dose goal (achieved eKt/V ¼ 1.16 � 0.08, sp Kt/V ¼ 1.32 � 0.09) and to dialysis with either high-flux dialysers (b2-microglobulin clearance of > 20 mL/min) or to low-flux dialysers—(b2-microglobulin clearance < 10 mL/ min). The results showed that a higher HD dose was not associated with a lower mortality risk compared with con- ventional HD dose (8). Thus, while a minimumKt/V ,a ccord- ing to the guidelines, is mandatory, the HEMO study clearly demonstrated that there are no advantages in further increas- ing the urea Kt/V, even in the high-flux membrane group. At the same time, each 10 mg/L increase in b2-M level was associated with an 11% increase in mortality, even after ad- justment for years on dialysis and residual kidney function. These results deserve further specifically designed studies in order to clarify if it is a matter of larger molecule removal or better fluid removal. In the other large trial in the field, the Membrane Perme- ability Outcome study, there was no significant difference in survival between high- and low-flux groups when all patients were included in the analysis (9). However, patients with serum albumin � 40 g/L on enrolment and with diabetes had a significantly better survival in the high-flux arm. High-flux dialysis was associated with a significantly lower accumulation of b2-microglobulin. Again, it is important to clarify if the better outcome was related to larger molecule removal or better fluid removal. Compared with conventional HD, HDF could theoretically offer some advantages: better clearance of middle- and" @default.
• W2114215087 created "2016-06-24" @default.
• W2114215087 creator A5046429359 @default.
• W2114215087 creator A5071768099 @default.
• W2114215087 creator A5085317331 @default.
• W2114215087 date "2012-01-01" @default.
• W2114215087 modified "2023-10-17" @default.
• W2114215087 title "Uraemic toxins versus volume and water as the major factor that matters with dialysis" @default.
• W2114215087 cites W1501077658 @default.
• W2114215087 cites W1588165263 @default.
• W2114215087 cites W1778417577 @default.
• W2114215087 cites W1960352796 @default.
• W2114215087 cites W1989631524 @default.
• W2114215087 cites W1996669601 @default.
• W2114215087 cites W2003701024 @default.
• W2114215087 cites W2005792758 @default.
• W2114215087 cites W2006863228 @default.
• W2114215087 cites W2009326517 @default.
• W2114215087 cites W2011578243 @default.
• W2114215087 cites W2027119414 @default.
• W2114215087 cites W2036233716 @default.
• W2114215087 cites W2048325364 @default.
• W2114215087 cites W2049937445 @default.
• W2114215087 cites W2056169637 @default.
• W2114215087 cites W2064296101 @default.
• W2114215087 cites W2067368112 @default.
• W2114215087 cites W2083362503 @default.
• W2114215087 cites W2084614341 @default.
• W2114215087 cites W2089009763 @default.
• W2114215087 cites W2089341196 @default.
• W2114215087 cites W2095083866 @default.
• W2114215087 cites W2102324358 @default.
• W2114215087 cites W2105379431 @default.
• W2114215087 cites W2106967227 @default.
• W2114215087 cites W2109012519 @default.
• W2114215087 cites W2109921402 @default.
• W2114215087 cites W2115611820 @default.
• W2114215087 cites W2118291100 @default.
• W2114215087 cites W2124204552 @default.
• W2114215087 cites W2125707967 @default.
• W2114215087 cites W2133808321 @default.
• W2114215087 cites W2134113277 @default.
• W2114215087 cites W2137230081 @default.
• W2114215087 cites W2137938257 @default.
• W2114215087 cites W2149448546 @default.
• W2114215087 cites W2156690704 @default.
• W2114215087 cites W2160119333 @default.
• W2114215087 cites W2161437331 @default.
• W2114215087 cites W2162787538 @default.
• W2114215087 cites W2167215662 @default.
• W2114215087 cites W2171091764 @default.
• W2114215087 doi "https://doi.org/10.1093/ndt/gfr636" @default.
• W2114215087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22287702" @default.
• W2114215087 hasPublicationYear "2012" @default.
• W2114215087 type Work @default.
• W2114215087 sameAs 2114215087 @default.
• W2114215087 citedByCount "12" @default.
• W2114215087 countsByYear W21142150872012 @default.
• W2114215087 countsByYear W21142150872013 @default.
• W2114215087 countsByYear W21142150872014 @default.
• W2114215087 countsByYear W21142150872015 @default.
• W2114215087 countsByYear W21142150872016 @default.
• W2114215087 countsByYear W21142150872018 @default.
• W2114215087 countsByYear W21142150872022 @default.
• W2114215087 crossrefType "journal-article" @default.
• W2114215087 hasAuthorship W2114215087A5046429359 @default.
• W2114215087 hasAuthorship W2114215087A5071768099 @default.
• W2114215087 hasAuthorship W2114215087A5085317331 @default.
• W2114215087 hasBestOaLocation W21142150871 @default.
• W2114215087 hasConcept C121332964 @default.
• W2114215087 hasConcept C126322002 @default.
• W2114215087 hasConcept C126894567 @default.
• W2114215087 hasConcept C177713679 @default.
• W2114215087 hasConcept C20556612 @default.
• W2114215087 hasConcept C2778063415 @default.
• W2114215087 hasConcept C2779978075 @default.
• W2114215087 hasConcept C2994496059 @default.
• W2114215087 hasConcept C62520636 @default.
• W2114215087 hasConcept C71924100 @default.
• W2114215087 hasConceptScore W2114215087C121332964 @default.
• W2114215087 hasConceptScore W2114215087C126322002 @default.
• W2114215087 hasConceptScore W2114215087C126894567 @default.
• W2114215087 hasConceptScore W2114215087C177713679 @default.
• W2114215087 hasConceptScore W2114215087C20556612 @default.
• W2114215087 hasConceptScore W2114215087C2778063415 @default.
• W2114215087 hasConceptScore W2114215087C2779978075 @default.
• W2114215087 hasConceptScore W2114215087C2994496059 @default.
• W2114215087 hasConceptScore W2114215087C62520636 @default.
• W2114215087 hasConceptScore W2114215087C71924100 @default.
• W2114215087 hasIssue "1" @default.
• W2114215087 hasLocation W21142150871 @default.
• W2114215087 hasLocation W21142150872 @default.
• W2114215087 hasOpenAccess W2114215087 @default.
• W2114215087 hasPrimaryLocation W21142150871 @default.
• W2114215087 hasRelatedWork W2056606314 @default.
• W2114215087 hasRelatedWork W2417281742 @default.
• W2114215087 hasRelatedWork W2556420081 @default.
• W2114215087 hasRelatedWork W2735484227 @default.

• next