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• W2114230130 endingPage "20" @default.
• W2114230130 startingPage "1" @default.
• W2114230130 abstract "A low voltage-activated potassium current, IKL, is found in auditory neuron types that have low excitability and precisely preserve the temporal pattern of activity present in their presynaptic inputs. The gene Kcna1 codes for Kv1.1 potassium channel subunits, which combine in expression systems to produce channel tetramers with properties similar to those of IKL, including sensitivity to dendrotoxin (DTX). Kv1.1 is strongly expressed in neurons with IKL, including auditory neurons of the medial nucleus of the trapezoid body (MNTB). We therefore decided to investigate how the absence of Kv1.1 affected channel properties and function in MNTB neurons from mice lacking Kcna1. We used the whole cell version of the patch clamp technique to record from MNTB neurons in brainstem slices from Kcna1-null (-/-) mice and their wild-type (+/+) and heterozygous (+/-) littermates. There was an IKL in voltage-clamped -/- MNTB neurons, but it was about half the amplitude of the IKL in +/+ neurons, with otherwise similar properties. Consistent with this, -/- MNTB neurons were more excitable than their +/+ counterparts; they fired more than twice as many action potentials (APs) during current steps, and the threshold current amplitude required to generate an AP was roughly halved. +/- MNTB neurons had excitability and IKL amplitudes identical to the +/+ neurons. The IKL remaining in -/- neurons was blocked by DTX, suggesting the underlying channels contained subunits Kv1.2 and/or Kv1.6 (also DTX-sensitive). DTX increased excitability further in the already hyperexcitable -/- MNTB neurons, suggesting that -/- IKL limited excitability despite its reduced amplitude in the absence of Kv1.1 subunits." @default.
• W2114230130 created "2016-06-24" @default.
• W2114230130 creator A5008043781 @default.
• W2114230130 creator A5013735387 @default.
• W2114230130 creator A5034866576 @default.
• W2114230130 date "2003-02-28" @default.
• W2114230130 modified "2023-09-26" @default.
• W2114230130 title "Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1" @default.
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• W2114230130 doi "https://doi.org/10.1113/jphysiol.2002.035568" @default.
• W2114230130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2342794" @default.
• W2114230130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12611922" @default.
• W2114230130 hasPublicationYear "2003" @default.
• W2114230130 type Work @default.

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