Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114242407> ?p ?o ?g. }
- W2114242407 abstract "The ubiquitous α-catulin acts as a scaffold for distinct signalosomes including RhoA/ROCK; however, its function is not well understood. While α-catulin has homology to the cytoskeletal linkers α-catenin and vinculin, it appears to be functionally divergent. Here we further investigated α-catulin function in pulmonary vascular endothelial cells (VEC) on the premise that α-catulin has a unique cytoskeletal role. Examination of endogenous α-catulin intracellular localization by immunofluorescence revealed a highly organized cytosolic filamentous network suggestive of a cytoskeletal system in a variety of cultured VEC. Double-immunofluorescence analyses of VEC showed endogenous α-catulin co-localization with vimentin intermediate filaments. Similar to vimentin, α-catulin was found to distribute into detergent-soluble and -insoluble fractions. Treatment of VEC with withaferinA, an agent that targets vimentin filaments, disrupted the α-catulin network distribution and altered α-catulin solubility. Vimentin participates in cell migration, and withaferinA was found to inhibit VEC migration in vitro; similarly, α-catulin knock-down reduced VEC migration. Based on previous reports showing that ROCK modulates vimentin, we found that ROCK depletion attenuated VEC migration; furthermore, α-catulin depletion was shown to reduce ROCK-induced signaling. These findings indicate that α-catulin has a unique function in co-localization with vimentin filaments that contributes to VEC migration via a pathway that may involve ROCK signaling. J. Cell. Physiol. 231: 934-943, 2016. © 2015 Wiley Periodicals, Inc." @default.
- W2114242407 created "2016-06-24" @default.
- W2114242407 creator A5010237095 @default.
- W2114242407 creator A5021816444 @default.
- W2114242407 creator A5032763063 @default.
- W2114242407 creator A5048247289 @default.
- W2114242407 creator A5051301255 @default.
- W2114242407 creator A5056848755 @default.
- W2114242407 creator A5057580828 @default.
- W2114242407 creator A5061539249 @default.
- W2114242407 creator A5067984012 @default.
- W2114242407 date "2015-09-17" @default.
- W2114242407 modified "2023-10-17" @default.
- W2114242407 title "Alpha-Catulin Co-Localizes With Vimentin Intermediate Filaments and Functions in Pulmonary Vascular Endothelial Cell Migration via ROCK" @default.
- W2114242407 cites W1510189348 @default.
- W2114242407 cites W1908632331 @default.
- W2114242407 cites W1944127753 @default.
- W2114242407 cites W1970289555 @default.
- W2114242407 cites W1970989847 @default.
- W2114242407 cites W1977906490 @default.
- W2114242407 cites W1981207857 @default.
- W2114242407 cites W1998186648 @default.
- W2114242407 cites W2008679290 @default.
- W2114242407 cites W2012340416 @default.
- W2114242407 cites W2017101886 @default.
- W2114242407 cites W2031096972 @default.
- W2114242407 cites W2036431767 @default.
- W2114242407 cites W2038954901 @default.
- W2114242407 cites W2040195528 @default.
- W2114242407 cites W2044467611 @default.
- W2114242407 cites W2053257956 @default.
- W2114242407 cites W2057875185 @default.
- W2114242407 cites W2061126410 @default.
- W2114242407 cites W2063220206 @default.
- W2114242407 cites W2075305683 @default.
- W2114242407 cites W2080944141 @default.
- W2114242407 cites W2082001892 @default.
- W2114242407 cites W2082388485 @default.
- W2114242407 cites W2086242462 @default.
- W2114242407 cites W2097712502 @default.
- W2114242407 cites W2101850916 @default.
- W2114242407 cites W2102312968 @default.
- W2114242407 cites W2105820147 @default.
- W2114242407 cites W2112634792 @default.
- W2114242407 cites W2117347109 @default.
- W2114242407 cites W2124143346 @default.
- W2114242407 cites W2125273210 @default.
- W2114242407 cites W2141807385 @default.
- W2114242407 cites W2146264066 @default.
- W2114242407 cites W2153366778 @default.
- W2114242407 cites W2166598280 @default.
- W2114242407 cites W2172210768 @default.
- W2114242407 cites W2418007592 @default.
- W2114242407 doi "https://doi.org/10.1002/jcp.25185" @default.
- W2114242407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26377600" @default.
- W2114242407 hasPublicationYear "2015" @default.
- W2114242407 type Work @default.
- W2114242407 sameAs 2114242407 @default.
- W2114242407 citedByCount "7" @default.
- W2114242407 countsByYear W21142424072016 @default.
- W2114242407 countsByYear W21142424072017 @default.
- W2114242407 countsByYear W21142424072018 @default.
- W2114242407 countsByYear W21142424072021 @default.
- W2114242407 crossrefType "journal-article" @default.
- W2114242407 hasAuthorship W2114242407A5010237095 @default.
- W2114242407 hasAuthorship W2114242407A5021816444 @default.
- W2114242407 hasAuthorship W2114242407A5032763063 @default.
- W2114242407 hasAuthorship W2114242407A5048247289 @default.
- W2114242407 hasAuthorship W2114242407A5051301255 @default.
- W2114242407 hasAuthorship W2114242407A5056848755 @default.
- W2114242407 hasAuthorship W2114242407A5057580828 @default.
- W2114242407 hasAuthorship W2114242407A5061539249 @default.
- W2114242407 hasAuthorship W2114242407A5067984012 @default.
- W2114242407 hasConcept C137738243 @default.
- W2114242407 hasConcept C142669718 @default.
- W2114242407 hasConcept C147447768 @default.
- W2114242407 hasConcept C1491633281 @default.
- W2114242407 hasConcept C159654299 @default.
- W2114242407 hasConcept C185592680 @default.
- W2114242407 hasConcept C190062978 @default.
- W2114242407 hasConcept C203014093 @default.
- W2114242407 hasConcept C204232928 @default.
- W2114242407 hasConcept C2778236600 @default.
- W2114242407 hasConcept C55493867 @default.
- W2114242407 hasConcept C78383274 @default.
- W2114242407 hasConcept C79879829 @default.
- W2114242407 hasConcept C86803240 @default.
- W2114242407 hasConcept C95444343 @default.
- W2114242407 hasConceptScore W2114242407C137738243 @default.
- W2114242407 hasConceptScore W2114242407C142669718 @default.
- W2114242407 hasConceptScore W2114242407C147447768 @default.
- W2114242407 hasConceptScore W2114242407C1491633281 @default.
- W2114242407 hasConceptScore W2114242407C159654299 @default.
- W2114242407 hasConceptScore W2114242407C185592680 @default.
- W2114242407 hasConceptScore W2114242407C190062978 @default.
- W2114242407 hasConceptScore W2114242407C203014093 @default.
- W2114242407 hasConceptScore W2114242407C204232928 @default.
- W2114242407 hasConceptScore W2114242407C2778236600 @default.
- W2114242407 hasConceptScore W2114242407C55493867 @default.
- W2114242407 hasConceptScore W2114242407C78383274 @default.