FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114245875> ?p ?o ?g. }

• W2114245875 endingPage "129" @default.
• W2114245875 startingPage "122" @default.
• W2114245875 abstract "The purpose of this study was to produce mucoadhesive nanocarriers made from chitosan (CS) and hyaluronic acid (HA), and containing the macromolecular drug heparin, suitable for pulmonary delivery. For the first time, this drug was tested in ex vivo experiments performed in mast cells, in order to investigate the potential of the heparin-loaded nanocarriers in antiasthmatic therapy. CS and mixtures of HA with unfractionated or low-molecular-weight heparin (UFH and LMWH, respectively) were combined to form nanoparticles by the ionotropic gelation technique. The resulting nanoparticles loaded with UFH were between 162 and 217 nm in size, and those prepared with LMWH were 152 nm. The zeta potential of the nanoparticle formulations ranged from +28.1 to +34.6 mV, and in selected nanosystems both types of heparin were associated with a high degree of efficiency, which was approximately 70%. The nanosystems were stable in phosphate buffered saline (PBS), pH 7.4, for at least 24h, and released 10.8% of UFH and 79.7% of LMWH within 12h of incubation. Confocal microscopy experiments showed that fluorescent heparin-loaded CS-HA nanoparticles were effectively internalized by rat mast cells. Ex vivo experiments aimed at evaluating the capacity of heparin to prevent histamine release in rat mast cells indicated that the free or encapsulated drug exhibited the same dose-response behaviour." @default.
• W2114245875 created "2016-06-24" @default.
• W2114245875 creator A5015194083 @default.
• W2114245875 creator A5031298057 @default.
• W2114245875 creator A5058712463 @default.
• W2114245875 creator A5060553322 @default.
• W2114245875 creator A5064817004 @default.
• W2114245875 date "2009-11-01" @default.
• W2114245875 modified "2023-10-17" @default.
• W2114245875 title "Chitosan–hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma" @default.
• W2114245875 cites W109957402 @default.
• W2114245875 cites W1883311425 @default.
• W2114245875 cites W1978128526 @default.
• W2114245875 cites W1982431512 @default.
• W2114245875 cites W1982643537 @default.
• W2114245875 cites W198388497 @default.
• W2114245875 cites W2004934441 @default.
• W2114245875 cites W2013168158 @default.
• W2114245875 cites W2019853172 @default.
• W2114245875 cites W2025164642 @default.
• W2114245875 cites W2035263671 @default.
• W2114245875 cites W2051845904 @default.
• W2114245875 cites W2073259676 @default.
• W2114245875 cites W2073649604 @default.
• W2114245875 cites W2073687825 @default.
• W2114245875 cites W2074677088 @default.
• W2114245875 cites W2079881663 @default.
• W2114245875 cites W2079990868 @default.
• W2114245875 cites W2081337060 @default.
• W2114245875 cites W2089973870 @default.
• W2114245875 cites W2093850349 @default.
• W2114245875 cites W2106169256 @default.
• W2114245875 cites W2112515081 @default.
• W2114245875 cites W2134726909 @default.
• W2114245875 cites W2142810940 @default.
• W2114245875 cites W2149695880 @default.
• W2114245875 cites W2161245887 @default.
• W2114245875 doi "https://doi.org/10.1016/j.ijpharm.2009.04.009" @default.
• W2114245875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19467809" @default.
• W2114245875 hasPublicationYear "2009" @default.
• W2114245875 type Work @default.
• W2114245875 sameAs 2114245875 @default.
• W2114245875 citedByCount "189" @default.
• W2114245875 countsByYear W21142458752012 @default.
• W2114245875 countsByYear W21142458752013 @default.
• W2114245875 countsByYear W21142458752014 @default.
• W2114245875 countsByYear W21142458752015 @default.
• W2114245875 countsByYear W21142458752016 @default.
• W2114245875 countsByYear W21142458752017 @default.
• W2114245875 countsByYear W21142458752018 @default.
• W2114245875 countsByYear W21142458752019 @default.
• W2114245875 countsByYear W21142458752020 @default.
• W2114245875 countsByYear W21142458752021 @default.
• W2114245875 countsByYear W21142458752022 @default.
• W2114245875 countsByYear W21142458752023 @default.
• W2114245875 crossrefType "journal-article" @default.
• W2114245875 hasAuthorship W2114245875A5015194083 @default.
• W2114245875 hasAuthorship W2114245875A5031298057 @default.
• W2114245875 hasAuthorship W2114245875A5058712463 @default.
• W2114245875 hasAuthorship W2114245875A5060553322 @default.
• W2114245875 hasAuthorship W2114245875A5064817004 @default.
• W2114245875 hasConcept C105702510 @default.
• W2114245875 hasConcept C1122143 @default.
• W2114245875 hasConcept C150903083 @default.
• W2114245875 hasConcept C155672457 @default.
• W2114245875 hasConcept C171250308 @default.
• W2114245875 hasConcept C178790620 @default.
• W2114245875 hasConcept C18150654 @default.
• W2114245875 hasConcept C185592680 @default.
• W2114245875 hasConcept C192562407 @default.
• W2114245875 hasConcept C202751555 @default.
• W2114245875 hasConcept C204399865 @default.
• W2114245875 hasConcept C207001950 @default.
• W2114245875 hasConcept C26291073 @default.
• W2114245875 hasConcept C2776884760 @default.
• W2114245875 hasConcept C2777529286 @default.
• W2114245875 hasConcept C2777557582 @default.
• W2114245875 hasConcept C2779732960 @default.
• W2114245875 hasConcept C2779820397 @default.
• W2114245875 hasConcept C55493867 @default.
• W2114245875 hasConcept C71924100 @default.
• W2114245875 hasConcept C86181022 @default.
• W2114245875 hasConcept C86803240 @default.
• W2114245875 hasConcept C98274493 @default.
• W2114245875 hasConceptScore W2114245875C105702510 @default.
• W2114245875 hasConceptScore W2114245875C1122143 @default.
• W2114245875 hasConceptScore W2114245875C150903083 @default.
• W2114245875 hasConceptScore W2114245875C155672457 @default.
• W2114245875 hasConceptScore W2114245875C171250308 @default.
• W2114245875 hasConceptScore W2114245875C178790620 @default.
• W2114245875 hasConceptScore W2114245875C18150654 @default.
• W2114245875 hasConceptScore W2114245875C185592680 @default.
• W2114245875 hasConceptScore W2114245875C192562407 @default.
• W2114245875 hasConceptScore W2114245875C202751555 @default.
• W2114245875 hasConceptScore W2114245875C204399865 @default.
• W2114245875 hasConceptScore W2114245875C207001950 @default.
• W2114245875 hasConceptScore W2114245875C26291073 @default.
• W2114245875 hasConceptScore W2114245875C2776884760 @default.

• next