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• W2114255736 abstract "No AccessJournal of UrologyTestis1 Sep 1997A Platelet Activating Factor Antagonist Attenuates the Effects of Testicular Ischemia Jeffrey S. Palmer, William J. Cromie, Louis F. Plzak, and Alan R. Leff Jeffrey S. PalmerJeffrey S. Palmer More articles by this author , William J. CromieWilliam J. Cromie More articles by this author , Louis F. PlzakLouis F. Plzak More articles by this author , and Alan R. LeffAlan R. Leff More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64420-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Platelet activating factor, a biochemical marker and lipid mediator of ischemic injury, has been demonstrated in several organ systems. The objective of this study was to investigate the possible role of platelet activating factor in testicular ischemic injury. Materials and Methods: Five groups of 6 male Sprague-Dawley rats were studied, including group 1-nonoperated controls, group 2-sham operated controls, group 3-those that underwent administration of 10 micro g./kg. exogenous platelet activating factor into the left testicular artery, group 4-those that underwent 4 hours of testicular ischemia and group 5-those that received pretreatment with 0.4 mg./kg. of the platelet activating factor antagonist CV-6209 intravenously before 4 hours of testicular ischemia. Ipsilateral and contralateral testes were examined histologically and seminiferous tubular diameters were measured. Results: Exogenous platelet activating factor administration in group 3 and 4 hours of ischemia in group 4 resulted in a similar extent of histological degeneration of the experimental testicle. Pretreatment with CV-6209 in group 5 resulted in a marked decrease in hemorrhagic discoloration, vascular congestion and histological changes noted with ischemia in group 4. Conclusions: The results of this study suggest that platelet activating factor has a biochemical role in tissue injury associated with testicular ischemia. Also, administration of a platelet activating factor antagonist before the ischemic event decreases seminiferous tubule degeneration. References 1 : Testicular salvage and age-related delay in the presentation of testicular torsion.. J. Urol.1989; 142: 746. Abstract, Google Scholar 2 : The testes after torsion.. Brit. J. Urol.1978; 50: 43. Google Scholar 3 : Testicular ischemia-reperfusion injury is attenuated by a mild surfactant.. Surg. Forum1996; 47: 794. Google Scholar 4 : An experimental study of the effect of ischemia on testicular structure in the rat: efficacy of intravenous inosine.. J. Androl.1983; 4: 378. Google Scholar 5 : Morphologic changes induced by short-term ischemia in the rat testis are not affected by treatment with superoxide dismutase and catalase.. J. Androl.1988; 9: 15. Google Scholar 6 : Effects of hypothermia on testicular ischemia.. J. Urol.1990; 143: 1046. Abstract, Google Scholar 7 : Cellular changes from graded testicular ischemia.. J. Urol.1955; 73: 355. Abstract, Google Scholar 8 : Experimental torsion of the spermatic cord.. Surg. Forum1961; 12: 502. Google Scholar 9 : Histopathology of prepubertal rat tested subjected to various durations of spermatic cord torsion.. J. Androl.1986; 7: 23. Google Scholar 10 : Enzymes as markers of testicular growth and development in the rat.. Endocrinology1973; 93: 985. Google Scholar 11 : Long-term study of the immuno-pathological consequences of sympathetic orchiopathia in the rat.. J. Reprod. Fertil.1987; 80: 641. Google Scholar 12 : Deleterious effects of testicular venous occlusion in young rats.. Surg., Gynec. & Obst.1990; 171: 382. Google Scholar 13 : Immunohistochemical demonstration of platelet activating factor (PAF) in rat hippocampus after global brain ischemia.. FASEB J.1992; 6: A1317. abstract 2203. Google Scholar 14 : Changes in [3H]PAF binding and PAF concentrations in gerbil brain after bilateral common carotid artery occlusion: a quantitative autoradiographic study.. Brain Res.1994; 640: 268. Google Scholar 15 : Glomeruli from ischemic rat kidney produce increased amount of platelet activating factor.. Biochem. Biophys. Res. Comm.1988; 152: 129. Google Scholar 16 : Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury.. Prostagl. Leukotr. Ess. Fatty Acids1988; 34: 53. Google Scholar 17 : Role of thromboxane A2 and platelet-activating factor in allergic bronchoconstriction in guinea pig airway in vivo.. J. Lipid Mediat. Cell Sig.1995; 11: 1. Google Scholar 18 : Detection of platelet activating factor in exudate of rats with phorbolmyristate acetate-induced pleurisy.. Thromb. Res.1987; 48: 299. Google Scholar 19 : Platelet-activating factor-induced coronary constriction in the isolated perfused guinea pig heart and antagonistic effects of the PAF antagonist WEB 2086.. J. Lipid Mediat.1990; 2: 9. Google Scholar 20 : Ischemia aggravating effect of platelet activating factor in acute myocardial ischemia.. Basic Res. Cardiol.1985; 80: 135. Google Scholar 21 : Platelet-activating factor (PAF) in male reproductive organs of guinea pigs and rats: effect of androgen on PAF in seminal vesicles.. Biol. Reprod.1993; 48: 386. Google Scholar 22 : Biochim. The CoA-independent transacylase in PAF biosynthesis: tissue distribution and molecular species selectivity.. Biophys. Acta1995; 1254: 295. Google Scholar 23 : CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo.. J. Pharmacol. Exp. Ther.1987; 242: 263. Google Scholar 24 : Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia.. J. Pharmacol. Exp. Ther.1988; 244: 898. Google Scholar 25 : Effects of a platelet-activating factor antagonist, CV-6209, on gastric mucosal lesions induced by ischemia-reperfusion.. Lipids1992; 27: 1058. Google Scholar 26 : Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats.. Surgery1993; 113: 76. Google Scholar 27 : Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.. J. Clin. Invest.1985; 76: 271. Google Scholar 28 : Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked.. Biochem. J.1985; 229: 811. Google Scholar 29 : Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds.. Brit. J. Pharmacol.1992; 105: 87. Google Scholar 30 : Platelet activating factor (PAF): a review of its effects, antagonists and possible future clinical implications (part I).. Drugs1991; 42: 9. Google Scholar 31 : Platelet activating factor (PAF): a review of its effects, antagonists and possible future clinical implications (Part II).. Drugs1991; 42: 174. Google Scholar 32 : Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor).. J. Immunol.1981; 127: 1250. Google Scholar 33 : Monocyte aggregation and superoxide anion release in response to formylmethionyl-leucyl-phenyalanine (FMLP) and platelet-activating factor (PAF).. J. Immunol.1982; 128: 1939. Google Scholar 34 : Platelet activating factor antagonists.. Adv. Pharmacol.1995; 32: 67. Google Scholar 35 : Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients: a preliminary study.. Prostaglandins1987; 34: 723. Google Scholar 36 : Treatment of adult systemic mastocytosis with a PAF-acether antagonist BN 52063. Letter to the Editor.. Lancet1988; 2: 114. Google Scholar 37 : Inhibitory effects of the new PAF acether antagonist WEB 2086 on pharmacologic changes induced by PAF inhalation in human beings.. Clin. Pharmacol. Ther.1990; 47: 456. Google Scholar 38 : Platelet activating factor involvement in splanchnic artery occlusion shock in rats.. Eur. J. Pharmacol.1991; 192: 47. Google Scholar 39 : Effects of Gingko biloba on changes induced by quantitative cerebral microembolization in rats.. Arch. Int. Pharmacodyn. Ther.1980; 243: 236. Google Scholar 40 : Platelet-activating factor and cerebral vasospasm following subarachnoid hemorrhage.. J. Neurosurg.1993; 78: 592. Google Scholar 41 : Experimental model of ischemic bowel necrosis: the role of platelet-activating factor and endotoxin.. Amer. J. Path.1983; 112: 127. Google Scholar 42 : Platelet-activating factor: a potent constrictor of cerebral arterioles in newborn pigs.. Circ. Res.1988; 62: 1. Google Scholar 43 : Effect of PAF on parasympathetic contraction of canine airways.. J. App. Physiol.1989; 66: 2629. Google Scholar 44 : PAF-antagonists as potential therapeutic agents in cardiac anaphylaxis and myocardial ischemia.. Cardiovasc. Drug Rev.1989; 7: 177. Google Scholar 45 : Platelet-activating factor and progressive brain damage following focal brain injury.. J. Neurosurg.1990; 73: 223. Google Scholar 46 : Histological changes occurring in the contralateral testes of prepubertal rats subjected to various durations of unilateral spermatic cord torsion.. J. Urol.1985; 133: 906. Abstract, Google Scholar 47 : The action of platelet activating factor and its antagonism by WEB 2086 on human isolated airways.. Eur. Resp. J.1990; 3: 55. Google Scholar From the Sections of Urology and Pulmonary/Critical Care Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byPalmer L (2012) Editorial CommentJournal of Urology, VOL. 188, NO. 4S, (1422-1422), Online publication date: 1-Oct-2012. Volume 158Issue 3September 1997Page: 1186-1190 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Jeffrey S. Palmer More articles by this author William J. Cromie More articles by this author Louis F. Plzak More articles by this author Alan R. Leff More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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