Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114299877> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2114299877 endingPage "3107" @default.
- W2114299877 startingPage "3102" @default.
- W2114299877 abstract "Although bedtime salivary cortisol measurement has been proposed as the optimal screening test for the diagnosis of Cushing's syndrome, its performance using commercially available assays has not been widely evaluated.Our objective was to compare RIA and tandem mass spectrometry (LC-MS/MS) measurement of salivary cortisol in obese subjects and healthy volunteers.We conducted a cross-sectional prospective study of outpatients.We studied 261 obese subjects (186 female) with at least two additional features of Cushing's syndrome and 60 healthy volunteers (30 female). Subjects provided split bedtime salivary samples for cortisol measurement by commercially available RIA and LC-MS/MS. Results were considered normal or abnormal based on the laboratory reference range. Subjects with abnormal results underwent evaluation for Cushing's syndrome.In paired samples, RIA gave a lower specificity than LC-MS/MS in obese subjects (86 vs. 94%, P = 0.008) but not healthy volunteers (86 vs. 82%, P = 0.71). Among subjects with at least one abnormal result, both values were abnormal in 44% (confidence interval 26-62%) of obese and 75% (confidence interval 33-96%) of healthy volunteers. In obese subjects, salivary cortisol concentrations were less than 4.0 to 643 ng/dl (<0.11-17.7 nmol/liter; normal, < or =100 ng/dl, 2.80 nmol/liter) by LC-MS/MS and less than 50 to 2800 ng/dl (1.4-77.3 nmol/liter; normal, < or =170 ng/dl, 4.7 nmol/liter) by RIA. Cushing's syndrome was not diagnosed in any subject.Salivary cortisol levels should not be used as the sole test to diagnose Cushing's syndrome if laboratory-provided reference ranges are used for diagnostic interpretation." @default.
- W2114299877 created "2016-06-24" @default.
- W2114299877 creator A5015205366 @default.
- W2114299877 creator A5042333408 @default.
- W2114299877 creator A5043403667 @default.
- W2114299877 creator A5049689973 @default.
- W2114299877 creator A5060266336 @default.
- W2114299877 date "2007-08-01" @default.
- W2114299877 modified "2023-09-27" @default.
- W2114299877 title "Radioimmunoassay and Tandem Mass Spectrometry Measurement of Bedtime Salivary Cortisol Levels: A Comparison of Assays to Establish Hypercortisolism" @default.
- W2114299877 cites W1917375005 @default.
- W2114299877 cites W1941083590 @default.
- W2114299877 cites W1976461290 @default.
- W2114299877 cites W1998981829 @default.
- W2114299877 cites W2004140568 @default.
- W2114299877 cites W2015795623 @default.
- W2114299877 cites W2023934963 @default.
- W2114299877 cites W2033314834 @default.
- W2114299877 cites W2089490142 @default.
- W2114299877 cites W2147773011 @default.
- W2114299877 cites W2150814515 @default.
- W2114299877 cites W2152269109 @default.
- W2114299877 cites W2153233391 @default.
- W2114299877 cites W2168487042 @default.
- W2114299877 cites W2419324624 @default.
- W2114299877 doi "https://doi.org/10.1210/jc.2006-2861" @default.
- W2114299877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17550962" @default.
- W2114299877 hasPublicationYear "2007" @default.
- W2114299877 type Work @default.
- W2114299877 sameAs 2114299877 @default.
- W2114299877 citedByCount "122" @default.
- W2114299877 countsByYear W21142998772012 @default.
- W2114299877 countsByYear W21142998772013 @default.
- W2114299877 countsByYear W21142998772014 @default.
- W2114299877 countsByYear W21142998772015 @default.
- W2114299877 countsByYear W21142998772016 @default.
- W2114299877 countsByYear W21142998772017 @default.
- W2114299877 countsByYear W21142998772018 @default.
- W2114299877 countsByYear W21142998772019 @default.
- W2114299877 countsByYear W21142998772020 @default.
- W2114299877 countsByYear W21142998772021 @default.
- W2114299877 countsByYear W21142998772022 @default.
- W2114299877 countsByYear W21142998772023 @default.
- W2114299877 crossrefType "journal-article" @default.
- W2114299877 hasAuthorship W2114299877A5015205366 @default.
- W2114299877 hasAuthorship W2114299877A5042333408 @default.
- W2114299877 hasAuthorship W2114299877A5043403667 @default.
- W2114299877 hasAuthorship W2114299877A5049689973 @default.
- W2114299877 hasAuthorship W2114299877A5060266336 @default.
- W2114299877 hasBestOaLocation W21142998771 @default.
- W2114299877 hasConcept C126322002 @default.
- W2114299877 hasConcept C134018914 @default.
- W2114299877 hasConcept C176674119 @default.
- W2114299877 hasConcept C176685330 @default.
- W2114299877 hasConcept C2778537899 @default.
- W2114299877 hasConcept C2779435821 @default.
- W2114299877 hasConcept C2780221984 @default.
- W2114299877 hasConcept C44249647 @default.
- W2114299877 hasConcept C504460877 @default.
- W2114299877 hasConcept C71924100 @default.
- W2114299877 hasConceptScore W2114299877C126322002 @default.
- W2114299877 hasConceptScore W2114299877C134018914 @default.
- W2114299877 hasConceptScore W2114299877C176674119 @default.
- W2114299877 hasConceptScore W2114299877C176685330 @default.
- W2114299877 hasConceptScore W2114299877C2778537899 @default.
- W2114299877 hasConceptScore W2114299877C2779435821 @default.
- W2114299877 hasConceptScore W2114299877C2780221984 @default.
- W2114299877 hasConceptScore W2114299877C44249647 @default.
- W2114299877 hasConceptScore W2114299877C504460877 @default.
- W2114299877 hasConceptScore W2114299877C71924100 @default.
- W2114299877 hasIssue "8" @default.
- W2114299877 hasLocation W21142998771 @default.
- W2114299877 hasLocation W21142998772 @default.
- W2114299877 hasOpenAccess W2114299877 @default.
- W2114299877 hasPrimaryLocation W21142998771 @default.
- W2114299877 hasRelatedWork W1980166143 @default.
- W2114299877 hasRelatedWork W1982640511 @default.
- W2114299877 hasRelatedWork W2027340926 @default.
- W2114299877 hasRelatedWork W2027703819 @default.
- W2114299877 hasRelatedWork W2043105234 @default.
- W2114299877 hasRelatedWork W2069848618 @default.
- W2114299877 hasRelatedWork W2072014172 @default.
- W2114299877 hasRelatedWork W2075131187 @default.
- W2114299877 hasRelatedWork W2153052119 @default.
- W2114299877 hasRelatedWork W2159598174 @default.
- W2114299877 hasVolume "92" @default.
- W2114299877 isParatext "false" @default.
- W2114299877 isRetracted "false" @default.
- W2114299877 magId "2114299877" @default.
- W2114299877 workType "article" @default.