Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114300510> ?p ?o ?g. }
- W2114300510 endingPage "10292" @default.
- W2114300510 startingPage "10286" @default.
- W2114300510 abstract "The results of seroepidemiological studies suggest that infection with adeno-associated virus type 2 (AAV2) is negatively correlated with the incidence of human papillomavirus (HPV)-associated cervical cancer. We studied the potential of AAV2 oncosuppression of HPV and showed that HPV/AAV2 coinfection of cells culminated in apoptotic death, as determined by DNA laddering and caspase-3 cleavage. The induction of apoptosis coincided with AAV2 Rep protein expression; increased S-phase progression; upregulated pRb displaying both hyper- and hypophosphorylated forms; increased levels of p21(WAF1), p16(INK4), and p27(KIP1) proteins; and diminished levels of E7 oncoprotein. In contrast, normal keratinocytes that were infected with AAV2 or transfected with the cloned full-length AAV2 genome failed to express Rep proteins or undergo apoptosis. The failure of AAV2 to productively infect normal keratinocytes could be clinically advantageous. The delineation of the molecular mechanisms underlying the HPV/AAV2 interaction could be harnessed for developing novel AAV2-derived therapeutics for cervical cancer." @default.
- W2114300510 created "2016-06-24" @default.
- W2114300510 creator A5010485889 @default.
- W2114300510 creator A5027544951 @default.
- W2114300510 date "2009-10-01" @default.
- W2114300510 modified "2023-09-26" @default.
- W2114300510 title "Adeno-Associated Virus Type 2 Induces Apoptosis in Human Papillomavirus-Infected Cell Lines but Not in Normal Keratinocytes" @default.
- W2114300510 cites W1504161778 @default.
- W2114300510 cites W1562069246 @default.
- W2114300510 cites W1570055816 @default.
- W2114300510 cites W1572539012 @default.
- W2114300510 cites W1621865896 @default.
- W2114300510 cites W1987106185 @default.
- W2114300510 cites W1993076319 @default.
- W2114300510 cites W1993616429 @default.
- W2114300510 cites W1998497535 @default.
- W2114300510 cites W1999082138 @default.
- W2114300510 cites W2002489396 @default.
- W2114300510 cites W2008757142 @default.
- W2114300510 cites W2012250005 @default.
- W2114300510 cites W2013534167 @default.
- W2114300510 cites W2023860639 @default.
- W2114300510 cites W2027217514 @default.
- W2114300510 cites W2028043537 @default.
- W2114300510 cites W2029206805 @default.
- W2114300510 cites W2031753415 @default.
- W2114300510 cites W2039334966 @default.
- W2114300510 cites W2066825523 @default.
- W2114300510 cites W2091965894 @default.
- W2114300510 cites W2107307536 @default.
- W2114300510 cites W2108071106 @default.
- W2114300510 cites W2110160400 @default.
- W2114300510 cites W2114208687 @default.
- W2114300510 cites W2122191644 @default.
- W2114300510 cites W2128595345 @default.
- W2114300510 cites W2151390094 @default.
- W2114300510 cites W2154713717 @default.
- W2114300510 cites W2163278605 @default.
- W2114300510 cites W2170075776 @default.
- W2114300510 cites W68610681 @default.
- W2114300510 doi "https://doi.org/10.1128/jvi.00343-09" @default.
- W2114300510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2748052" @default.
- W2114300510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19625406" @default.
- W2114300510 hasPublicationYear "2009" @default.
- W2114300510 type Work @default.
- W2114300510 sameAs 2114300510 @default.
- W2114300510 citedByCount "7" @default.
- W2114300510 countsByYear W21143005102012 @default.
- W2114300510 countsByYear W21143005102014 @default.
- W2114300510 countsByYear W21143005102016 @default.
- W2114300510 countsByYear W21143005102019 @default.
- W2114300510 countsByYear W21143005102021 @default.
- W2114300510 crossrefType "journal-article" @default.
- W2114300510 hasAuthorship W2114300510A5010485889 @default.
- W2114300510 hasAuthorship W2114300510A5027544951 @default.
- W2114300510 hasBestOaLocation W21143005101 @default.
- W2114300510 hasConcept C155878803 @default.
- W2114300510 hasConcept C159047783 @default.
- W2114300510 hasConcept C190283241 @default.
- W2114300510 hasConcept C2522874641 @default.
- W2114300510 hasConcept C31573885 @default.
- W2114300510 hasConcept C43759708 @default.
- W2114300510 hasConcept C502942594 @default.
- W2114300510 hasConcept C54009773 @default.
- W2114300510 hasConcept C54355233 @default.
- W2114300510 hasConcept C81885089 @default.
- W2114300510 hasConcept C86803240 @default.
- W2114300510 hasConceptScore W2114300510C155878803 @default.
- W2114300510 hasConceptScore W2114300510C159047783 @default.
- W2114300510 hasConceptScore W2114300510C190283241 @default.
- W2114300510 hasConceptScore W2114300510C2522874641 @default.
- W2114300510 hasConceptScore W2114300510C31573885 @default.
- W2114300510 hasConceptScore W2114300510C43759708 @default.
- W2114300510 hasConceptScore W2114300510C502942594 @default.
- W2114300510 hasConceptScore W2114300510C54009773 @default.
- W2114300510 hasConceptScore W2114300510C54355233 @default.
- W2114300510 hasConceptScore W2114300510C81885089 @default.
- W2114300510 hasConceptScore W2114300510C86803240 @default.
- W2114300510 hasIssue "19" @default.
- W2114300510 hasLocation W21143005101 @default.
- W2114300510 hasLocation W21143005102 @default.
- W2114300510 hasLocation W21143005103 @default.
- W2114300510 hasLocation W21143005104 @default.
- W2114300510 hasOpenAccess W2114300510 @default.
- W2114300510 hasPrimaryLocation W21143005101 @default.
- W2114300510 hasRelatedWork W1487857142 @default.
- W2114300510 hasRelatedWork W1971489322 @default.
- W2114300510 hasRelatedWork W2015509069 @default.
- W2114300510 hasRelatedWork W2110509379 @default.
- W2114300510 hasRelatedWork W2156128416 @default.
- W2114300510 hasRelatedWork W2165332541 @default.
- W2114300510 hasRelatedWork W2166379079 @default.
- W2114300510 hasRelatedWork W2337834220 @default.
- W2114300510 hasRelatedWork W2567016505 @default.
- W2114300510 hasRelatedWork W1605849848 @default.
- W2114300510 hasVolume "83" @default.
- W2114300510 isParatext "false" @default.
- W2114300510 isRetracted "false" @default.