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• W2114311013 startingPage "27" @default.
• W2114311013 abstract "Summary: Murine listeriosis was introduced 35 years ago as a model with which to analyze mechanisms of antibacterial defense that are independent of antibodies. Listeria monocytogenes was shown to be an intramacrophage pathogen with capacity to induce the generation of a state of specific immunity in the form of DTH and a macrophage system with enhanced non-specific bactericidal activity The demonstration that anti-Listeria immunity and DTH can be passively transferred with T cells was taken to indicate that the T cells responsible for DTH function upregulate the listericidal function of macrophages. This interpretation is contradicted by recent research showing that CDS T cells, rather than CD4 T cells, are responsible for mediating adoptive immunity. However, T-cell depletion studies show that primary infection can eventually be resolved in the absence of either CDS or CD4 T cells. On the other hand, infection becomes lethal in the absence of neutrophils or NK cells. It is apparent, therefore, that the most important defense against primary listeriosis resides with the functions of neutrophils and NK cells that are mobilized early in infection. Antigen-specific T cells function at a later time to infection more efficiently. It is apparent that T cells are much more important in defense against secondary infection." @default.
• W2114311013 created "2016-06-24" @default.
• W2114311013 creator A5007115947 @default.
• W2114311013 creator A5007179531 @default.
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• W2114311013 date "1997-08-01" @default.
• W2114311013 modified "2023-09-27" @default.
• W2114311013 title "Murine listeriosis as a model of antimicrobial defense" @default.
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• W2114311013 doi "https://doi.org/10.1111/j.1600-065x.1997.tb00989.x" @default.
• W2114311013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9314071" @default.
• W2114311013 hasPublicationYear "1997" @default.
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