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• W2114312977 abstract "Macrophages have been implicated in myelin damage in experimental autoimmune neuritis (EAN). We examined a possible pathogenetic role of toxic oxygen species elaborated by macrophages in EAN by administering oxygen radical scavengers. Early treatment of rats with either catalase or superoxide dismutase (10,000 U/kg/day) protected animals from the development of EAN. Treatment delayed until there was clinical manifestation of EAN (day 13) still markedly attenuated the severity of the disease, as evidenced by clinical assessment, electrophysiological studies, and morphological observation. In cell culture, macrophages from sham-treated controls generated heightened oxidative metabolic responses indicating in vivo macrophage activation. Addition of catalase or superoxide dismutase abrogated or diminished chemiluminescence and production of reactive oxygen intermediates by macrophages ex vivo. Our findings underscore the importance of macrophages in EAN and provide evidence that, in this model, macrophage-derived reactive oxygen intermediates contribute to damage of the myelin sheath." @default.
• W2114312977 created "2016-06-24" @default.
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• W2114312977 date "1988-05-01" @default.
• W2114312977 modified "2023-09-27" @default.
• W2114312977 title "Suppression of experimental autoimmune neuritis by the oxygen radical scavengers superoxide dismutase and catalase" @default.
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• W2114312977 doi "https://doi.org/10.1002/ana.410230505" @default.
• W2114312977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3260463" @default.
• W2114312977 hasPublicationYear "1988" @default.
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