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• W2114313124 abstract "Study objective To investigate the acute effect ofmannitol on the clearance of mucus, and (1) the 24-h mucus retention, and (2) the mucus clearance rate and lung function 24 h afterinhalation of a single dose of mannitol. Design Clearance of mucus was measured on 3 consecutive days using99mTc-sulfur colloid radioaerosol and a gamma camera. Interventions Mannitol, 330 ± 68 mg (mean± SD), wasinhaled using a dry powder inhaler only on day 2. Patients Eight patients with bronchiectasis (age range, 29to 70 years). Measurements and results On each day, lung images were collected over 2 h and at 24 h. Key findingsof the study are as follows: (1) the 24-h retention of mucus wasreduced the day after mannitol had been inhaled, compared to the daywithout mannitol (day 1) in the whole right lung (57.6 ± 6.2% vs68.1 ± 5.9%), central (47.5 ± 6.7% vs 56.9 ± 6.5%),intermediate (61.7 ± 5.6% vs 73.8 ± 5.5%), and peripheralregions (70.9 ± 4.3% vs 86.6 ± 4.6%)(p < 0.02); and (2)mannitol helped patients clear mucus within 2 h that mightotherwise take up to 24 h, from the whole right lung and definedregions. However, clearance over 60 min measured 24 h aftermannitol inhalation was not significantly different to baselineclearance without mannitol (8.7 ± 1.9% on day 1 vs 9.7 ± 3.7%24 h after mannitol; p > 0.8). The patients maintained the samelung function the day before and after mannitol had been inhaled: FEV1 (percent predicted), 79 ± 5 on day 1 vs 80 ± 5on day 3; and forced expiratory flow, midexpiratory phase (percentpredicted), 50 ± 6 on day 1 vs 51 ± 6 on day 3;p > 0.6). Conclusions Mannitol inhalationacutely increases clearance of mucus, and this effect extends beyondthe acute study period, resulting in decreased mucus retention at24 h. To investigate the acute effect ofmannitol on the clearance of mucus, and (1) the 24-h mucus retention, and (2) the mucus clearance rate and lung function 24 h afterinhalation of a single dose of mannitol. Clearance of mucus was measured on 3 consecutive days using99mTc-sulfur colloid radioaerosol and a gamma camera. Mannitol, 330 ± 68 mg (mean± SD), wasinhaled using a dry powder inhaler only on day 2. Eight patients with bronchiectasis (age range, 29to 70 years). On each day, lung images were collected over 2 h and at 24 h. Key findingsof the study are as follows: (1) the 24-h retention of mucus wasreduced the day after mannitol had been inhaled, compared to the daywithout mannitol (day 1) in the whole right lung (57.6 ± 6.2% vs68.1 ± 5.9%), central (47.5 ± 6.7% vs 56.9 ± 6.5%),intermediate (61.7 ± 5.6% vs 73.8 ± 5.5%), and peripheralregions (70.9 ± 4.3% vs 86.6 ± 4.6%)(p < 0.02); and (2)mannitol helped patients clear mucus within 2 h that mightotherwise take up to 24 h, from the whole right lung and definedregions. However, clearance over 60 min measured 24 h aftermannitol inhalation was not significantly different to baselineclearance without mannitol (8.7 ± 1.9% on day 1 vs 9.7 ± 3.7%24 h after mannitol; p > 0.8). The patients maintained the samelung function the day before and after mannitol had been inhaled: FEV1 (percent predicted), 79 ± 5 on day 1 vs 80 ± 5on day 3; and forced expiratory flow, midexpiratory phase (percentpredicted), 50 ± 6 on day 1 vs 51 ± 6 on day 3;p > 0.6). Mannitol inhalationacutely increases clearance of mucus, and this effect extends beyondthe acute study period, resulting in decreased mucus retention at24 h." @default.
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• W2114313124 date "2001-02-01" @default.
• W2114313124 modified "2023-09-24" @default.
• W2114313124 title "The 24-h Effect of Mannitol on the Clearance of Mucus in Patients With Bronchiectasis" @default.
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• W2114313124 doi "https://doi.org/10.1378/chest.119.2.414" @default.
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