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• W2114313145 abstract "We have used immunofluorescence imaging to study binding of a monoclonal antibody fragment to subcutaneously implanted human melanoma cells in nude mice. The data acquired using this nontraditional approach was then analyzed using standard pharmacokinetic methods to produce estimates of k(e) (0.06h(-1)), t 1/2 (16 h), mean residency time (23.4 h) and percent exposure of the antibody to the tumor (40%). To our knowledge this is the first time standard pharmacokinetic analyzes have been conducted on immunofluorescence imaging data. The combination of this novel imaging technique and standard pharmacokinetic analytical methods should prove to be a useful tool for comparing the properties of antibody fragments in animal models." @default.
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• W2114313145 date "2002-10-01" @default.
• W2114313145 modified "2023-09-25" @default.
• W2114313145 title "Immunofluorescence imaging as a tool for studying the pharmacokinetics of a human monoclonal single chain fragment antibody" @default.
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• W2114313145 doi "https://doi.org/10.1109/tmi.2002.806275" @default.
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