FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114328886> ?p ?o ?g. }

• W2114328886 endingPage "1776" @default.
• W2114328886 startingPage "1771" @default.
• W2114328886 abstract "Postmenopausal estrogen replacement therapy (ERT) has an antioxidant effect that opposes the oxidation of LDL particles. Oral ERT-induced increases in plasma triglyceride, however, decrease LDL particle size, which may counteract this antioxidant effect. Because transdermal ERT decreases plasma triglyceride, it may not decrease LDL particle size and may preserve estrogen's antioxidant effect. The present study investigates whether transdermal ERT can eliminate the adverse effects of oral ERT on the size and oxidative susceptibility of LDL in postmenopausal women.Postmenopausal women received no treatment (n=12) or were treated with either 0.625 mg oral conjugated equine estrogen daily (n=16) or with transdermal estradiol (50 microg/d, n=16) for 3 months. Plasma lipids and the diameter of LDL particles were determined. Susceptibility of LDL to oxidation was analyzed by incubation with CuSO4 and subsequent measurement of thiobarbituric acid reactive substance (TBARS) concentrations. Oral ERT significantly increased plasma triglyceride and decreased LDL diameter but did not affect LDL-derived TBARS concentrations. In contrast, transdermal ERT significantly decreased the concentrations of plasma triglyceride and LDL-derived TBARS and significantly increased LDL diameter. Estrogen-induced changes in LDL diameter correlated negatively with changes in plasma triglyceride (r=-0.51, P<0.001) and LDL-derived TBARS (r=-0.50, P<0.001).Because transdermal, but not oral ERT, decreases plasma triglyceride and produces larger LDL particles that are resistant to oxidation, the antioxidant effect of estrogen can be preserved." @default.
• W2114328886 created "2016-06-24" @default.
• W2114328886 creator A5029867190 @default.
• W2114328886 creator A5030869139 @default.
• W2114328886 creator A5042683248 @default.
• W2114328886 creator A5057229680 @default.
• W2114328886 date "2002-10-01" @default.
• W2114328886 modified "2023-10-10" @default.
• W2114328886 title "Different Effects of Oral Conjugated Equine Estrogen and Transdermal Estrogen Replacement Therapy on Size and Oxidative Susceptibility of Low-Density Lipoprotein Particles in Postmenopausal Women" @default.
• W2114328886 cites W1946263363 @default.
• W2114328886 cites W1974381755 @default.
• W2114328886 cites W1981027567 @default.
• W2114328886 cites W1983310681 @default.
• W2114328886 cites W1988032344 @default.
• W2114328886 cites W1996810831 @default.
• W2114328886 cites W2012974823 @default.
• W2114328886 cites W2017215786 @default.
• W2114328886 cites W2039264048 @default.
• W2114328886 cites W2051034159 @default.
• W2114328886 cites W2051086756 @default.
• W2114328886 cites W2051170697 @default.
• W2114328886 cites W2054131763 @default.
• W2114328886 cites W2058386687 @default.
• W2114328886 cites W2068729533 @default.
• W2114328886 cites W2073737196 @default.
• W2114328886 cites W2078551570 @default.
• W2114328886 cites W2079731016 @default.
• W2114328886 cites W2093383681 @default.
• W2114328886 cites W2105194226 @default.
• W2114328886 cites W2113264115 @default.
• W2114328886 cites W2117492262 @default.
• W2114328886 cites W2164083481 @default.
• W2114328886 cites W2188087478 @default.
• W2114328886 cites W2332056249 @default.
• W2114328886 doi "https://doi.org/10.1161/01.cir.0000032261.12632.d7" @default.
• W2114328886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12356628" @default.
• W2114328886 hasPublicationYear "2002" @default.
• W2114328886 type Work @default.
• W2114328886 sameAs 2114328886 @default.
• W2114328886 citedByCount "60" @default.
• W2114328886 countsByYear W21143288862012 @default.
• W2114328886 countsByYear W21143288862014 @default.
• W2114328886 countsByYear W21143288862015 @default.
• W2114328886 countsByYear W21143288862016 @default.
• W2114328886 countsByYear W21143288862017 @default.
• W2114328886 countsByYear W21143288862020 @default.
• W2114328886 countsByYear W21143288862022 @default.
• W2114328886 countsByYear W21143288862023 @default.
• W2114328886 crossrefType "journal-article" @default.
• W2114328886 hasAuthorship W2114328886A5029867190 @default.
• W2114328886 hasAuthorship W2114328886A5030869139 @default.
• W2114328886 hasAuthorship W2114328886A5042683248 @default.
• W2114328886 hasAuthorship W2114328886A5057229680 @default.
• W2114328886 hasBestOaLocation W21143288861 @default.
• W2114328886 hasConcept C126322002 @default.
• W2114328886 hasConcept C134018914 @default.
• W2114328886 hasConcept C185592680 @default.
• W2114328886 hasConcept C205679159 @default.
• W2114328886 hasConcept C2776151105 @default.
• W2114328886 hasConcept C2777164284 @default.
• W2114328886 hasConcept C2777352226 @default.
• W2114328886 hasConcept C2778004101 @default.
• W2114328886 hasConcept C2778163477 @default.
• W2114328886 hasConcept C2778913445 @default.
• W2114328886 hasConcept C2780072125 @default.
• W2114328886 hasConcept C2780829032 @default.
• W2114328886 hasConcept C55493867 @default.
• W2114328886 hasConcept C71924100 @default.
• W2114328886 hasConcept C98274493 @default.
• W2114328886 hasConceptScore W2114328886C126322002 @default.
• W2114328886 hasConceptScore W2114328886C134018914 @default.
• W2114328886 hasConceptScore W2114328886C185592680 @default.
• W2114328886 hasConceptScore W2114328886C205679159 @default.
• W2114328886 hasConceptScore W2114328886C2776151105 @default.
• W2114328886 hasConceptScore W2114328886C2777164284 @default.
• W2114328886 hasConceptScore W2114328886C2777352226 @default.
• W2114328886 hasConceptScore W2114328886C2778004101 @default.
• W2114328886 hasConceptScore W2114328886C2778163477 @default.
• W2114328886 hasConceptScore W2114328886C2778913445 @default.
• W2114328886 hasConceptScore W2114328886C2780072125 @default.
• W2114328886 hasConceptScore W2114328886C2780829032 @default.
• W2114328886 hasConceptScore W2114328886C55493867 @default.
• W2114328886 hasConceptScore W2114328886C71924100 @default.
• W2114328886 hasConceptScore W2114328886C98274493 @default.
• W2114328886 hasIssue "14" @default.
• W2114328886 hasLocation W21143288861 @default.
• W2114328886 hasLocation W21143288862 @default.
• W2114328886 hasOpenAccess W2114328886 @default.
• W2114328886 hasPrimaryLocation W21143288861 @default.
• W2114328886 hasRelatedWork W1022173204 @default.
• W2114328886 hasRelatedWork W2032611441 @default.
• W2114328886 hasRelatedWork W2048452294 @default.
• W2114328886 hasRelatedWork W2105213195 @default.
• W2114328886 hasRelatedWork W2313417905 @default.
• W2114328886 hasRelatedWork W2338884341 @default.
• W2114328886 hasRelatedWork W2408368051 @default.
• W2114328886 hasRelatedWork W2431433609 @default.
• W2114328886 hasRelatedWork W3135427317 @default.

• next