FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114352296> ?p ?o ?g. }

• W2114352296 abstract "Chronic Obstructive Pulmonary Disease (COPD) is characterized by lung and systemic inflammation as well as airway goblet cell hyperplasia (GCH). Mucin production is activated in part by stimulation of the epidermal growth factor (EGF) receptor pathway through neutrophils and macrophages. How circulating cytokine levels relate to GCH is not clear.We performed phlebotomy and bronchoscopy on 25 subjects (six nonsmokers, 11 healthy smokers, and eight COPD subjects FEV1 30-60 %). Six endobronchial biopsies per subject were performed. GCH was measured by measuring mucin volume density (MVD) using stereological techniques on periodic acid fast-Schiff stained samples. We measured the levels of chemokines CXCL8/IL-8, CCL2/MCP-1, CCL7/MCP-3, CCL22/MCD, CCL3/MIP-1α, and CCL4/MIP-1β, and the cytokines IL-1, IL-4, IL-6, IL-9, IL-17, EGF, and vascular endothelial growth factor (VEGF). Differences between groups were assessed using one-way ANOVA, t test, or Chi squared test. Post hoc tests after ANOVA were performed using Bonferroni correction.MVD was highest in healthy smokers (27.78 ± 10.24 μL/mm(2)) compared to COPD subjects (16.82 ± 16.29 μL/mm(2), p = 0.216) and nonsmokers (3.42 ± 3.07 μL/mm(2), p < 0.0001). Plasma CXCL8 was highest in healthy smokers (11.05 ± 8.92 pg/mL) compared to nonsmokers (1.20 ± 21.92 pg/mL, p = 0.047) and COPD subjects (6.01 ± 5.90 pg/mL, p = 0.366). CCL22 and CCL4 followed the same trends. There were no significant differences in the other cytokines measured. When the subjects were divided into current smokers (healthy smokers and COPD current smokers) and non/ex-smokers (nonsmokers and COPD ex-smokers), plasma CXCL8, CCL22, CCL4, and MVD were greater in current smokers. No differences in other cytokines were seen. Plasma CXCL8 moderately correlated with MVD (r = 0.552, p = 0.003).In this small cohort, circulating levels of the chemokines CXCL8, CCL4, and CCL22, as well as MVD, attain the highest levels in healthy smokers compared to nonsmokers and COPD subjects. These findings seem to be driven by current smoking and are independent of airflow obstruction.These data suggest that smoking upregulates a systemic pattern of neutrophil and macrophage chemoattractant expression, and this correlates significantly with the development of goblet cell hyperplasia." @default.
• W2114352296 created "2016-06-24" @default.
• W2114352296 creator A5009003396 @default.
• W2114352296 creator A5054579636 @default.
• W2114352296 creator A5058140335 @default.
• W2114352296 creator A5063270831 @default.
• W2114352296 creator A5074854724 @default.
• W2114352296 creator A5075817809 @default.
• W2114352296 date "2015-09-30" @default.
• W2114352296 modified "2023-10-08" @default.
• W2114352296 title "Plasma Chemokine signature correlates with lung goblet cell hyperplasia in smokers with and without chronic obstructive pulmonary disease" @default.
• W2114352296 cites W1595890420 @default.
• W2114352296 cites W1961573346 @default.
• W2114352296 cites W1965763596 @default.
• W2114352296 cites W1974431676 @default.
• W2114352296 cites W1982275890 @default.
• W2114352296 cites W1982820261 @default.
• W2114352296 cites W1983264988 @default.
• W2114352296 cites W1984753107 @default.
• W2114352296 cites W1991265445 @default.
• W2114352296 cites W1991875400 @default.
• W2114352296 cites W1995902693 @default.
• W2114352296 cites W2004030776 @default.
• W2114352296 cites W2019099336 @default.
• W2114352296 cites W2044372590 @default.
• W2114352296 cites W2049021995 @default.
• W2114352296 cites W2067438849 @default.
• W2114352296 cites W2069641201 @default.
• W2114352296 cites W2079699037 @default.
• W2114352296 cites W2085671780 @default.
• W2114352296 cites W2088958973 @default.
• W2114352296 cites W2096700673 @default.
• W2114352296 cites W2099004448 @default.
• W2114352296 cites W2101549766 @default.
• W2114352296 cites W2105062499 @default.
• W2114352296 cites W2108782014 @default.
• W2114352296 cites W2110416990 @default.
• W2114352296 cites W2120374931 @default.
• W2114352296 cites W2127951128 @default.
• W2114352296 cites W2128685087 @default.
• W2114352296 cites W2140295891 @default.
• W2114352296 cites W2141979512 @default.
• W2114352296 cites W2144400988 @default.
• W2114352296 cites W2145466675 @default.
• W2114352296 cites W2151041131 @default.
• W2114352296 cites W2151137229 @default.
• W2114352296 cites W2151949719 @default.
• W2114352296 cites W2154204110 @default.
• W2114352296 cites W2159680207 @default.
• W2114352296 cites W2161357018 @default.
• W2114352296 cites W2161713331 @default.
• W2114352296 cites W2164192318 @default.
• W2114352296 cites W2164236314 @default.
• W2114352296 cites W2184267658 @default.
• W2114352296 cites W2394580196 @default.
• W2114352296 doi "https://doi.org/10.1186/s12890-015-0103-2" @default.
• W2114352296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4589974" @default.
• W2114352296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26424214" @default.
• W2114352296 hasPublicationYear "2015" @default.
• W2114352296 type Work @default.
• W2114352296 sameAs 2114352296 @default.
• W2114352296 citedByCount "12" @default.
• W2114352296 countsByYear W21143522962016 @default.
• W2114352296 countsByYear W21143522962017 @default.
• W2114352296 countsByYear W21143522962018 @default.
• W2114352296 countsByYear W21143522962019 @default.
• W2114352296 countsByYear W21143522962021 @default.
• W2114352296 crossrefType "journal-article" @default.
• W2114352296 hasAuthorship W2114352296A5009003396 @default.
• W2114352296 hasAuthorship W2114352296A5054579636 @default.
• W2114352296 hasAuthorship W2114352296A5058140335 @default.
• W2114352296 hasAuthorship W2114352296A5063270831 @default.
• W2114352296 hasAuthorship W2114352296A5074854724 @default.
• W2114352296 hasAuthorship W2114352296A5075817809 @default.
• W2114352296 hasBestOaLocation W21143522961 @default.
• W2114352296 hasConcept C126322002 @default.
• W2114352296 hasConcept C13373296 @default.
• W2114352296 hasConcept C142724271 @default.
• W2114352296 hasConcept C16020263 @default.
• W2114352296 hasConcept C165637977 @default.
• W2114352296 hasConcept C203014093 @default.
• W2114352296 hasConcept C2775941134 @default.
• W2114352296 hasConcept C2776780178 @default.
• W2114352296 hasConcept C2776914184 @default.
• W2114352296 hasConcept C2777714996 @default.
• W2114352296 hasConcept C2778690821 @default.
• W2114352296 hasConcept C3018587741 @default.
• W2114352296 hasConcept C529295009 @default.
• W2114352296 hasConcept C68324877 @default.
• W2114352296 hasConcept C71924100 @default.
• W2114352296 hasConcept C90924648 @default.
• W2114352296 hasConceptScore W2114352296C126322002 @default.
• W2114352296 hasConceptScore W2114352296C13373296 @default.
• W2114352296 hasConceptScore W2114352296C142724271 @default.
• W2114352296 hasConceptScore W2114352296C16020263 @default.
• W2114352296 hasConceptScore W2114352296C165637977 @default.
• W2114352296 hasConceptScore W2114352296C203014093 @default.
• W2114352296 hasConceptScore W2114352296C2775941134 @default.
• W2114352296 hasConceptScore W2114352296C2776780178 @default.
• W2114352296 hasConceptScore W2114352296C2776914184 @default.

• next