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- W2114352610 abstract "Non-hemolytic reactions are common adverse transfusion-associated events, and febrile episodes have been defined as febrile non-hemolytic transfusion reactions (FNHTR) (1). Leukoagglutinins of recipients or donors are believed to be the primary cause of many of these febrile reactions [1]. Recently, pre-storage white blood cell reduction was found to reduce the number of FNHTR from 0.45% to 0.11% [2]. We describe herein a patient with FNHTR after the transfusion of leukoreduced single-donor apheresis platelet concentrates (LR-PC). A 24-year-old Chinese woman was hospitalized with severe anemia (hemoglobin level of 2.8 g/dL), thrombocytopenia (24 10 lL), and leukocytosis (10,910 lL, blasts 75%). She was diagnosed with acute myeloid leukemia. She had no history of transfusion or pregnancy. The serum level of haptoglobin was 75 mg/dL (normal range; 17–169) on admission. She received 4 units of leukoreduced red cell concentrates (LR-RCC). On day 4 after admission, she received transfusion of 10 units of LR-PC for thrombocytopenia, with no allergic reaction. In Japan, equivalent to 10 units (=2000 mL) of whole-blood-derived platelet concentrates has been generally prepared by apheresis of a single-donor for one bag of LR-PC. In this patient, premed-" @default.
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- W2114352610 date "2009-12-01" @default.
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- W2114352610 title "Anti-haptoglobin antibody detection after febrile non-hemolytic transfusion reactions in a non-haptoglobin-deficient patient" @default.
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- W2114352610 doi "https://doi.org/10.1016/j.transci.2009.09.003" @default.
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