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• W2114370284 abstract "In sub-Saharan Africa a causal relationship has been established between hepatitis B virus (HBV) infection and membranous nephropathy (MN), especially in Black children. The most common method of treatment is interferon therapy, which is however, only effective in 30-40% of patients. The reason for this is unclear. The objective of this pilot study was to determine whether mutations in the complete surface gene of HBV isolated from Black children with HBV-associated MN before, during and after treatment with interferon, had any effect on treatment response and vice versa. HBV DNA was extracted from the serum of a responder, reverter and non-responder patient before, during (4 and 16 weeks) and after (40 weeks) IFN treatment. The preS1/preS2/S region was amplified and cloned, and the clones sequenced. Sequence analyses revealed the preS2 region to be the most variable in the reverter and non-responder and HBsAg was the most variable in the non-responder. Phylogenetic analysis showed that the viral population dynamics between the responder strains and the reverter/non-responder strains differed as a result of various mutations found within the surface gene. Thus the presence of mutations in preS2 and HBsAg of the non-responding patients may carry predictive markers for nonresponse but further investigation would be needed to conclusively prove this." @default.
• W2114370284 created "2016-06-24" @default.
• W2114370284 creator A5082846351 @default.
• W2114370284 date "2008-08-06" @default.
• W2114370284 modified "2023-09-27" @default.
• W2114370284 title "A RETROSPECTIVE STUDY CHARACTERIZING THE COMPLETE S OPEN READING FRAME OF HEPATITIS B VIRUS FROM BLACK CHILDREN WITH MEMBRANOUS NEPHROPATHY TREATED WITH INTERFERON ALPHA-2b" @default.
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