FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114375471> ?p ?o ?g. }

• W2114375471 endingPage "375" @default.
• W2114375471 startingPage "369" @default.
• W2114375471 abstract "The tyrosine kinase JAK1 and the transcription factors STAT1 and STAT3 are phosphorylated in response to epidermal growth factor (EGF) and other growth factors. We have used EGF receptor-transfected cell lines defective in individual JAKs to assess the roles of these kinases in STAT activation and signal transduction in response to EGF. Although JAK1 is phosphorylated in response to EGF, it is not required for STAT activation or for induction of the c-fos gene. STAT activation in JAK2- and TYK2-defective cells is also normal, and the tyrosine phosphorylation of these two kinases does not increase upon EGF stimulation in wild-type or JAK1-negative cells. In cells transfected with a kinase-negative mutant EGF receptor, there is no STAT activation in response to EGF and c-fos is not induced, showing that the kinase activity of the receptor is required, directly or indirectly, for these two responses. The data do not support a role for any of the three JAK family members tested in STAT activation and are consistent with a JAK-independent pathway in which the intrinsic kinase domain of the EGF receptor is crucial. Furthermore, data from transient transfection experiments in HeLa cells, using c-fos promoters lacking the STAT regulatory element c-sis-inducible element, indicate that this element may play only a minor role in the induction of c-fos by EGF in these cells." @default.
• W2114375471 created "2016-06-24" @default.
• W2114375471 creator A5028429493 @default.
• W2114375471 creator A5029776635 @default.
• W2114375471 creator A5037641016 @default.
• W2114375471 creator A5056924383 @default.
• W2114375471 creator A5067994300 @default.
• W2114375471 creator A5068788861 @default.
• W2114375471 creator A5086233725 @default.
• W2114375471 creator A5090427988 @default.
• W2114375471 date "1996-01-01" @default.
• W2114375471 modified "2023-10-16" @default.
• W2114375471 title "Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor" @default.
• W2114375471 cites W127609430 @default.
• W2114375471 cites W1425979353 @default.
• W2114375471 cites W1498102997 @default.
• W2114375471 cites W1521367633 @default.
• W2114375471 cites W1573821584 @default.
• W2114375471 cites W1743711678 @default.
• W2114375471 cites W1965398762 @default.
• W2114375471 cites W1968800299 @default.
• W2114375471 cites W1971013842 @default.
• W2114375471 cites W1971475788 @default.
• W2114375471 cites W1974027176 @default.
• W2114375471 cites W1979676829 @default.
• W2114375471 cites W1980632540 @default.
• W2114375471 cites W1981799488 @default.
• W2114375471 cites W1983630074 @default.
• W2114375471 cites W1984212762 @default.
• W2114375471 cites W1986021037 @default.
• W2114375471 cites W1994584656 @default.
• W2114375471 cites W1997785224 @default.
• W2114375471 cites W1997935194 @default.
• W2114375471 cites W1999028040 @default.
• W2114375471 cites W2000082154 @default.
• W2114375471 cites W2003579974 @default.
• W2114375471 cites W2003996476 @default.
• W2114375471 cites W2006650216 @default.
• W2114375471 cites W2007157318 @default.
• W2114375471 cites W2008577129 @default.
• W2114375471 cites W2012438019 @default.
• W2114375471 cites W2012588545 @default.
• W2114375471 cites W2014188686 @default.
• W2114375471 cites W2015469705 @default.
• W2114375471 cites W2016188929 @default.
• W2114375471 cites W2027286533 @default.
• W2114375471 cites W2029275361 @default.
• W2114375471 cites W2030828553 @default.
• W2114375471 cites W2032359283 @default.
• W2114375471 cites W2034974668 @default.
• W2114375471 cites W2036944273 @default.
• W2114375471 cites W2043006415 @default.
• W2114375471 cites W2044075747 @default.
• W2114375471 cites W2045798063 @default.
• W2114375471 cites W2052172628 @default.
• W2114375471 cites W2052977964 @default.
• W2114375471 cites W2059796872 @default.
• W2114375471 cites W2061236267 @default.
• W2114375471 cites W2062005942 @default.
• W2114375471 cites W2070242833 @default.
• W2114375471 cites W2073557222 @default.
• W2114375471 cites W2074664341 @default.
• W2114375471 cites W2077739943 @default.
• W2114375471 cites W2081350964 @default.
• W2114375471 cites W2090105988 @default.
• W2114375471 cites W2094111001 @default.
• W2114375471 cites W2095416319 @default.
• W2114375471 cites W2103174300 @default.
• W2114375471 cites W2109389988 @default.
• W2114375471 cites W2120056767 @default.
• W2114375471 cites W2136690547 @default.
• W2114375471 cites W2151712105 @default.
• W2114375471 cites W2167604659 @default.
• W2114375471 cites W2173560213 @default.
• W2114375471 cites W240647565 @default.
• W2114375471 cites W318497777 @default.
• W2114375471 cites W344384229 @default.
• W2114375471 cites W4553897 @default.
• W2114375471 doi "https://doi.org/10.1128/mcb.16.1.369" @default.
• W2114375471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/231011" @default.
• W2114375471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8524316" @default.
• W2114375471 hasPublicationYear "1996" @default.
• W2114375471 type Work @default.
• W2114375471 sameAs 2114375471 @default.
• W2114375471 citedByCount "218" @default.
• W2114375471 countsByYear W21143754712012 @default.
• W2114375471 countsByYear W21143754712013 @default.
• W2114375471 countsByYear W21143754712014 @default.
• W2114375471 countsByYear W21143754712016 @default.
• W2114375471 countsByYear W21143754712017 @default.
• W2114375471 countsByYear W21143754712018 @default.
• W2114375471 countsByYear W21143754712019 @default.
• W2114375471 countsByYear W21143754712020 @default.
• W2114375471 countsByYear W21143754712021 @default.
• W2114375471 countsByYear W21143754712023 @default.
• W2114375471 crossrefType "journal-article" @default.
• W2114375471 hasAuthorship W2114375471A5028429493 @default.
• W2114375471 hasAuthorship W2114375471A5029776635 @default.

• next