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• W2114383777 abstract "Myeloproliferation, myeloaccumulation (decreased apoptosis), inflammation, bone marrow fibrosis and angiogenesis are cardinal features of the Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). Histone deacetylases (HDACs) have a critical role in modulating gene expression and, accordingly, in the control of cell pathobiology and cancer development. HDAC inhibition has been shown to inhibit tumor growth (impaired myeloproliferation), to modulate the balance between pro- and antiapoptotic proteins in favor of apoptosis (enhanced apoptosis) and also to inhibit angiogenesis. Recently, enhanced HDAC enzyme activity has been found in CD34+cells from patients with PMF, enzyme activity levels highly exceeding those recorded in other chronic myeloproliferative neoplasms (CMPNs). The raised levels correlated to the degree of splenomegaly, suggesting that HDAC might be recruited as ET or PV progresses into myelofibrosis or PMF progresses into a more advanced stage. Accordingly, HDAC inhibition is an obvious novel therapeutic approach in these neoplasms. Using global gene expression profiling of whole blood from patients with CMPNs, we have found a pronounced deregulation of HDAC genes, involving significant up-regulation of the HDAC genes 9 and 11, with the highest expression levels being found in patients with ET (HDAC9 and 11), PMF (HDAC9) and CMPNs (both HDAC9 and HDAC11). Furthermore, we have identified that the HDAC6 gene is progressively expressed in patients with ET, PV and PMF, reflecting a steady accumulation of abnormally expressed HDAC6 during disease evolution. Our results lend further support to HDACs as important epigenetic targets in the future treatment of patients with CMPNs. Since the highest expression levels of HDAC genes were recorded in ET, in PMF and in the entire CMPN group, their down-regulation by HDAC inhibitors might be associated with decreased disease activity, including reduction of splenomegaly." @default.
• W2114383777 created "2016-06-24" @default.
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• W2114383777 date "2011-08-01" @default.
• W2114383777 modified "2023-09-30" @default.
• W2114383777 title "Increased gene expression of histone deacetylases in patients with Philadelphia-negative chronic myeloproliferative neoplasms" @default.
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• W2114383777 cites W1968972540 @default.
• W2114383777 cites W1969323007 @default.
• W2114383777 cites W1970658265 @default.
• W2114383777 cites W1979832500 @default.
• W2114383777 cites W1980334255 @default.
• W2114383777 cites W1983094204 @default.
• W2114383777 cites W1985845937 @default.
• W2114383777 cites W1990011854 @default.
• W2114383777 cites W1993230181 @default.
• W2114383777 cites W1995902306 @default.
• W2114383777 cites W2001519534 @default.
• W2114383777 cites W2002698073 @default.
• W2114383777 cites W2007268478 @default.
• W2114383777 cites W2009121506 @default.
• W2114383777 cites W2013186220 @default.
• W2114383777 cites W2019967976 @default.
• W2114383777 cites W2023437193 @default.
• W2114383777 cites W2029644449 @default.
• W2114383777 cites W2037362944 @default.
• W2114383777 cites W2039139796 @default.
• W2114383777 cites W2041204347 @default.
• W2114383777 cites W2046316599 @default.
• W2114383777 cites W2054240721 @default.
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• W2114383777 cites W2058943350 @default.
• W2114383777 cites W2059045913 @default.
• W2114383777 cites W2062845857 @default.
• W2114383777 cites W2065399757 @default.
• W2114383777 cites W2072669480 @default.
• W2114383777 cites W2075625882 @default.
• W2114383777 cites W2078901327 @default.
• W2114383777 cites W2079003739 @default.
• W2114383777 cites W2081098333 @default.
• W2114383777 cites W2086426033 @default.
• W2114383777 cites W2088314595 @default.
• W2114383777 cites W2091767482 @default.
• W2114383777 cites W2092722802 @default.
• W2114383777 cites W2093216476 @default.
• W2114383777 cites W2094855567 @default.
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• W2114383777 cites W2099803844 @default.
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• W2114383777 cites W2103612496 @default.
• W2114383777 cites W2106875723 @default.
• W2114383777 cites W2107040737 @default.
• W2114383777 cites W2107733280 @default.
• W2114383777 cites W2108017291 @default.
• W2114383777 cites W2110787699 @default.
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• W2114383777 cites W2121296685 @default.
• W2114383777 cites W2123032057 @default.
• W2114383777 cites W2123927456 @default.
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• W2114383777 cites W2326795317 @default.
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• W2114383777 doi "https://doi.org/10.3109/10428194.2011.597905" @default.
• W2114383777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21806350" @default.
• W2114383777 hasPublicationYear "2011" @default.
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