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• W2114388859 endingPage "207" @default.
• W2114388859 startingPage "201" @default.
• W2114388859 abstract "D-glucose at 5.6 mM reduces the progression of in vitro-produced (IVP) bovine embryos from the morula to the blastocyst stage and skews sex ratio towards males. Possibly, the presence of two transcriptionally active X-chromosomes compromises female embryo development through imbalance in glucose metabolism. Here, we have determined the threshold of embryo sensitivity to glucose, whether substitution of D-fructose for glucose reduces the selective loss of female embryos, and whether inhibition of an X-linked gene product, glucose 6-phosphate dehydrogenase (G6PD), normalizes sex ratio among bovine blastocysts. IVP zygotes were cultured in glucose-free medium to 72 hr post-insemination, at which time 8-cell embryos were selected for treatment and cultured until 144 hr post-insemination. Addition of 4 mM glucose at the 8-cell stage reduced (P < 0.05) the number of blastocyst that formed, whereas 2.5 and 1 mM glucose had no effect. Sex ratio in the presence of 4 and 2.5 mM glucose differed significantly from 0.5, while 1 mM glucose had no effect. D-fructose (5.6 mM) did not compromise development to blastocyst and did not alter the sex ratio of blastocysts that formed. When G6PD inhibitors (dehydroepiandrosterone: DHEA and 6-aminonicotinamide: 6-AN), which effectively inhibit the reduction of the NADPH-sensitive dye, brilliant cresyl blue (BCB) in bovine morulae, were added to the culture medium containing 4 mM glucose, embryo development was moderately reduced, but sex ratio skewing was corrected (with 6-AN) or lowered (with DHEA). In conclusion, glucose above 2.5 mM impairs bovine embryo development and increases sex ratio, most likely as a result of increased pentose-phosphate (PP) pathway activity in female embryos." @default.
• W2114388859 created "2016-06-24" @default.
• W2114388859 creator A5030373564 @default.
• W2114388859 creator A5062870602 @default.
• W2114388859 creator A5080355462 @default.
• W2114388859 creator A5084208131 @default.
• W2114388859 date "2005-01-01" @default.
• W2114388859 modified "2023-09-23" @default.
• W2114388859 title "Effects ofD-glucose concentration,D-fructose, and inhibitors of enzymes of the pentose phosphate pathway on the development and sex ratio of bovine blastocysts" @default.
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• W2114388859 doi "https://doi.org/10.1002/mrd.20342" @default.
• W2114388859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15968626" @default.
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