FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114391710> ?p ?o ?g. }

• W2114391710 endingPage "719" @default.
• W2114391710 startingPage "705" @default.
• W2114391710 abstract "This observer-blind study compared the prophylactic human papillomavirus (HPV) vaccines, Cervarix (GlaxoSmithKline) and Gardasil (Merck), by assessing immunogenicity and safety through one month after completion of the three-dose vaccination course. Women (n = 1106) were stratified by age (18-26, 27-35, 36-45 years) and randomized (1:1) to receive Cervarix (Months 0, 1, 6) or Gardasil (Months 0, 2, 6). At Month 7 after first vaccination, all women in the according-to-protocol cohort who were seronegative/DNA negative before vaccination for the HPV type analyzed had seroconverted for HPV-16 and HPV-18 serum neutralizing antibodies, as measured by pseudovirion-based neutralization assay (PBNA), except for two women aged 27-35 years in the Gardasil group who did not seroconvert for HPV-18 (98%). Geometric mean titers of serum neutralizing antibodies ranged from 2.3-4.8-fold higher for HPV-16 and 6.8-9.1-fold higher for HPV-18 after vaccination with Cervarix compared with Gardasil, across all age strata. In the total vaccinated cohort (all women who received at least one vaccine dose, regardless of their serological and DNA status prior to vaccination), Cervarix induced significantly higher serum neutralizing antibody titers in all age strata (p < 0.0001). Positivity rates for anti-HPV-16 and -18 neutralizing antibodies in cervicovaginal secretions and circulating HPV-16 and -18 specific memory B-cell frequencies were also higher after vaccination with Cervarix compared with Gardasil. Both vaccines were generally well tolerated. The incidence of unsolicited adverse events was comparable between vaccinated groups. The incidence of solicited symptoms was generally higher after Cervarix, injection site reactions being most common. However, compliance rates with the three-dose schedules were similarly high (>or= 84%) for both vaccines. Although the importance of differences in magnitude of immune response between these vaccines is unknown, they may represent determinants of duration of protection against HPV-16/18. Long-term studies evaluating duration of efficacy after vaccination are needed for both vaccines." @default.
• W2114391710 created "2016-06-24" @default.
• W2114391710 creator A5003127549 @default.
• W2114391710 creator A5019152388 @default.
• W2114391710 creator A5024186639 @default.
• W2114391710 creator A5039170447 @default.
• W2114391710 creator A5044659175 @default.
• W2114391710 creator A5044846996 @default.
• W2114391710 creator A5051264386 @default.
• W2114391710 creator A5058719258 @default.
• W2114391710 creator A5070555068 @default.
• W2114391710 creator A5075451688 @default.
• W2114391710 creator A5076088778 @default.
• W2114391710 date "2009-10-01" @default.
• W2114391710 modified "2023-10-12" @default.
• W2114391710 title "Comparison of the immunogenicity and safety of<i>Cervarix</i>™ and<i>Gardasil</i>^®human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18–45 years" @default.
• W2114391710 cites W146717125 @default.
• W2114391710 cites W1550722396 @default.
• W2114391710 cites W1966410885 @default.
• W2114391710 cites W1967699866 @default.
• W2114391710 cites W1969392374 @default.
• W2114391710 cites W1973196190 @default.
• W2114391710 cites W1978500243 @default.
• W2114391710 cites W1981726005 @default.
• W2114391710 cites W1983225666 @default.
• W2114391710 cites W1987350137 @default.
• W2114391710 cites W1988405618 @default.
• W2114391710 cites W1992519297 @default.
• W2114391710 cites W1993809002 @default.
• W2114391710 cites W2000659418 @default.
• W2114391710 cites W2001429203 @default.
• W2114391710 cites W2004594897 @default.
• W2114391710 cites W2005304154 @default.
• W2114391710 cites W2010057931 @default.
• W2114391710 cites W2020830322 @default.
• W2114391710 cites W2021427213 @default.
• W2114391710 cites W2023179470 @default.
• W2114391710 cites W2037099233 @default.
• W2114391710 cites W2045603270 @default.
• W2114391710 cites W2047580791 @default.
• W2114391710 cites W2048017469 @default.
• W2114391710 cites W2049095033 @default.
• W2114391710 cites W2050922850 @default.
• W2114391710 cites W2059707463 @default.
• W2114391710 cites W2069122035 @default.
• W2114391710 cites W2073678729 @default.
• W2114391710 cites W2081619150 @default.
• W2114391710 cites W2086404290 @default.
• W2114391710 cites W2088517066 @default.
• W2114391710 cites W2091001058 @default.
• W2114391710 cites W2094296437 @default.
• W2114391710 cites W2095426035 @default.
• W2114391710 cites W2098353281 @default.
• W2114391710 cites W2098491904 @default.
• W2114391710 cites W2099660384 @default.
• W2114391710 cites W2101196984 @default.
• W2114391710 cites W2106787323 @default.
• W2114391710 cites W2114550075 @default.
• W2114391710 cites W2114813165 @default.
• W2114391710 cites W2115532578 @default.
• W2114391710 cites W2116458521 @default.
• W2114391710 cites W2130891798 @default.
• W2114391710 cites W2130983220 @default.
• W2114391710 cites W2135053575 @default.
• W2114391710 cites W2147477922 @default.
• W2114391710 cites W2149768001 @default.
• W2114391710 cites W2150436558 @default.
• W2114391710 cites W2152869702 @default.
• W2114391710 cites W2156961356 @default.
• W2114391710 cites W2159416556 @default.
• W2114391710 cites W2159831861 @default.
• W2114391710 cites W2160498668 @default.
• W2114391710 cites W2160874245 @default.
• W2114391710 cites W2166559731 @default.
• W2114391710 cites W2166632132 @default.
• W2114391710 cites W2170592973 @default.
• W2114391710 cites W2171315155 @default.
• W2114391710 cites W2185678922 @default.
• W2114391710 cites W2288105023 @default.
• W2114391710 doi "https://doi.org/10.4161/hv.5.10.9518" @default.
• W2114391710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19684472" @default.
• W2114391710 hasPublicationYear "2009" @default.
• W2114391710 type Work @default.
• W2114391710 sameAs 2114391710 @default.
• W2114391710 citedByCount "363" @default.
• W2114391710 countsByYear W21143917102012 @default.
• W2114391710 countsByYear W21143917102013 @default.
• W2114391710 countsByYear W21143917102014 @default.
• W2114391710 countsByYear W21143917102015 @default.
• W2114391710 countsByYear W21143917102016 @default.
• W2114391710 countsByYear W21143917102017 @default.
• W2114391710 countsByYear W21143917102018 @default.
• W2114391710 countsByYear W21143917102019 @default.
• W2114391710 countsByYear W21143917102020 @default.
• W2114391710 countsByYear W21143917102021 @default.
• W2114391710 countsByYear W21143917102022 @default.
• W2114391710 countsByYear W21143917102023 @default.
• W2114391710 crossrefType "journal-article" @default.

• next