FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114391838> ?p ?o ?g. }

• W2114391838 endingPage "680" @default.
• W2114391838 startingPage "668" @default.
• W2114391838 abstract "Chronic lymphocytic leukemia (CLL) is a common disease with highly variable clinical course. Several recurrent chromosomal alterations are associated with prognosis and may guide risk-adapted therapy. We have developed a targeted genome-wide array to provide a robust tool for ascertaining abnormalities in CLL and to overcome limitations of the 4-marker fluorescence in situ hybridization (FISH). DNA from 180 CLL patients were hybridized to the qChip®Hemo array with a high density of probes covering commonly altered loci in CLL (11q22-q23, 13q14, and 17p13), nine focal regions (2p15-p16.1, 2p24.3, 2q13, 2q36.3-q37.1, 3p21.31, 8q24.21, 9p21.3, 10q24.32, and 18q21.32-q21.33) and two larger regions (6q14.1-q22.31 and 7q31.33-q33). Overall, 86% of the cases presented copy number alterations (CNA) by array. There was a high concordance of array findings with FISH (84% sensitivity, 100% specificity); all discrepancies corresponded to subclonal alterations detected only by FISH. A chromothripsis-like pattern was detected in eight cases. Three showed concomitant shattered 5p with gain of TERT along with isochromosome 17q. Presence of 11q loss was associated with shorter time to first treatment (P = 0.003), whereas 17p loss, increased genomic complexity, and chromothripsis were associated with shorter overall survival (P < 0.001, P = 0.001, and P = 0.02, respectively). In conclusion, we have validated a targeted array for the diagnosis of CLL that accurately detects, in a single experiment, all relevant CNAs, genomic complexity, chromothripsis, copy number neutral loss of heterozygosity, and CNAs not covered by the FISH panel. This test may be used as a practical tool to stratify CLL patients for routine diagnostics or clinical trials. © 2015 The Authors. Genes, Chromosomes & Cancer Published by Wiley Periodicals, Inc." @default.
• W2114391838 created "2016-06-24" @default.
• W2114391838 creator A5006053526 @default.
• W2114391838 creator A5010733763 @default.
• W2114391838 creator A5020702876 @default.
• W2114391838 creator A5024516606 @default.
• W2114391838 creator A5033486428 @default.
• W2114391838 creator A5034573068 @default.
• W2114391838 creator A5039660745 @default.
• W2114391838 creator A5043549091 @default.
• W2114391838 creator A5048051369 @default.
• W2114391838 creator A5050933998 @default.
• W2114391838 creator A5059097260 @default.
• W2114391838 creator A5059971180 @default.
• W2114391838 creator A5068724005 @default.
• W2114391838 creator A5070169057 @default.
• W2114391838 creator A5074453036 @default.
• W2114391838 creator A5076083064 @default.
• W2114391838 creator A5077551755 @default.
• W2114391838 creator A5078999372 @default.
• W2114391838 creator A5081421128 @default.
• W2114391838 creator A5081516283 @default.
• W2114391838 creator A5081889907 @default.
• W2114391838 creator A5088901076 @default.
• W2114391838 creator A5088963827 @default.
• W2114391838 creator A5090007935 @default.
• W2114391838 date "2015-08-25" @default.
• W2114391838 modified "2023-10-16" @default.
• W2114391838 title "Detection of chromothripsis‐like patterns with a custom array platform for chronic lymphocytic leukemia" @default.
• W2114391838 cites W146673805 @default.
• W2114391838 cites W1574122583 @default.
• W2114391838 cites W1608820084 @default.
• W2114391838 cites W1766895399 @default.
• W2114391838 cites W1917864116 @default.
• W2114391838 cites W1969665013 @default.
• W2114391838 cites W1972822870 @default.
• W2114391838 cites W1978406461 @default.
• W2114391838 cites W1980260104 @default.
• W2114391838 cites W1980417277 @default.
• W2114391838 cites W1985758276 @default.
• W2114391838 cites W1990826225 @default.
• W2114391838 cites W1994979282 @default.
• W2114391838 cites W1998493020 @default.
• W2114391838 cites W1999233413 @default.
• W2114391838 cites W2015299436 @default.
• W2114391838 cites W2018034694 @default.
• W2114391838 cites W2022054497 @default.
• W2114391838 cites W2022565871 @default.
• W2114391838 cites W2023976667 @default.
• W2114391838 cites W2024927918 @default.
• W2114391838 cites W2027210182 @default.
• W2114391838 cites W2028777633 @default.
• W2114391838 cites W2031121711 @default.
• W2114391838 cites W2033740225 @default.
• W2114391838 cites W2035117018 @default.
• W2114391838 cites W2039356250 @default.
• W2114391838 cites W2042567225 @default.
• W2114391838 cites W2055898543 @default.
• W2114391838 cites W2060766609 @default.
• W2114391838 cites W2065377819 @default.
• W2114391838 cites W2066254965 @default.
• W2114391838 cites W2069401990 @default.
• W2114391838 cites W2072839232 @default.
• W2114391838 cites W2080959192 @default.
• W2114391838 cites W2091168608 @default.
• W2114391838 cites W2091838381 @default.
• W2114391838 cites W2093774016 @default.
• W2114391838 cites W2095969626 @default.
• W2114391838 cites W2096036897 @default.
• W2114391838 cites W2096643040 @default.
• W2114391838 cites W2102036352 @default.
• W2114391838 cites W2102284860 @default.
• W2114391838 cites W2104383933 @default.
• W2114391838 cites W2121906867 @default.
• W2114391838 cites W2140606816 @default.
• W2114391838 cites W2141524442 @default.
• W2114391838 cites W2142099365 @default.
• W2114391838 cites W2154911534 @default.
• W2114391838 cites W2156169904 @default.
• W2114391838 cites W2157596388 @default.
• W2114391838 cites W2159140367 @default.
• W2114391838 cites W2163702290 @default.
• W2114391838 cites W2165603851 @default.
• W2114391838 cites W2167045537 @default.
• W2114391838 cites W2169559274 @default.
• W2114391838 cites W2318933236 @default.
• W2114391838 cites W2323897083 @default.
• W2114391838 cites W4245197960 @default.
• W2114391838 doi "https://doi.org/10.1002/gcc.22277" @default.
• W2114391838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4832286" @default.
• W2114391838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26305789" @default.
• W2114391838 hasPublicationYear "2015" @default.
• W2114391838 type Work @default.
• W2114391838 sameAs 2114391838 @default.
• W2114391838 citedByCount "23" @default.
• W2114391838 countsByYear W21143918382016 @default.
• W2114391838 countsByYear W21143918382017 @default.
• W2114391838 countsByYear W21143918382018 @default.

• next