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- W2114401934 abstract "Abstract Introduction The safety and efficacy of liraglutide in combination with an oral antidiabetic drug ( OAD ) compared with combination of two OAD s were assessed in Japanese patients with type 2 diabetes. Materials and Methods This was a 52‐week, open‐label, parallel‐group trial in which patients whose type 2 diabetes was inadequately controlled with a single OAD (glinide, metformin, α‐glucosidase inhibitor or thiazolidinedione) were randomized 2:1 to either pretrial OAD in combination with liraglutide 0.9 mg/day (liraglutide group; n = 240) or pretrial OAD in combination with an additional OAD (additional OAD group; n = 120). The primary outcome measure was the incidence of adverse events ( AE s). Results Overall, 86.3% of patients in the liraglutide group and 85.0% of patients in the additional OAD group experienced AE s; these were similar in nature and severity. Adverse event rates were 361 and 331 per 100 patient‐years of exposure, respectively. Confirmed hypoglycemia was rare (seven episodes in two patients on liraglutide, and two in two patients on additional OAD ). There were no reported pancreatitis events, and no unexpected safety signals were identified. Mean reductions in glycosylated hemoglobin were significantly greater in the liraglutide group than the additional OAD group [estimated mean treatment difference −0.27% (95% confidence interval (CI) −0.44, −0.09; P = 0.0026)]; reductions in mean fasting plasma glucose levels were also greater with liraglutide [estimated mean difference −5.47 mg/ dL (−0.30 mmol/L; 95% CI: −10.83, −0.10; P = 0.0458)]. Conclusions Liraglutide was well tolerated and effective as combination therapy with an OAD in Japanese patients with type 2 diabetes." @default.
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- W2114401934 date "2015-07-14" @default.
- W2114401934 modified "2023-09-27" @default.
- W2114401934 title "Liraglutide is effective and well tolerated in combination with an oral antidiabetic drug in Japanese patients with type 2 diabetes: A randomized, 52‐week, open‐label, parallel‐group trial" @default.
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- W2114401934 doi "https://doi.org/10.1111/jdi.12367" @default.
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