Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114414114> ?p ?o ?g. }
- W2114414114 endingPage "55" @default.
- W2114414114 startingPage "48" @default.
- W2114414114 abstract "Molecular mechanism of differentiation in lipogenic tumor is still unknown in detail. Low-density lipoprotein receptor-related protein (LRP) and peroxisome proliferator-activated receptor gamma (PPAR-gamma), representative regulatory molecules of lipogenic differentiation, have been reported today as multi-functional molecules and to modulate tumorigenesis in various kind of cancer. To date, diagnostic and therapeutic significance of the expression of these molecules in lipogenic tumors are not defined.The immunohistochemical expression status of LRP and PPAR-gamma in various grades of 54 lipogenic tumors was analyzed. Correlation between the expression levels and the differentiation of the tumors was confirmed. For statistical analyses, the Kruskal-Wallis test, the Steel-Dwass test and the Mann-Whitney U test were used.LRP and PPAR-gamma expression was detected in 50 (92.6%) and 44 (81.5%) cases, respectively. The expression level in LRP was significantly higher in cases with well differentiated liposarcoma, pleomorphic liposarcoma and dedifferentiated liposarcoma than in lipoma. Compared with lipoma or well differentiated liposarcoma, significant elevation in expression level of PPAR-gamma was confirmed in myxoid liposarcoma, pleomorphic liposarcoma, dedifferentiated liposarcoma and the differentiated area of dedifferentiated liposarcoma.The up-regulation of LRP and PPAR-gamma in higher grade cases, i.e. less differentiated tumors than in low grade cases was shown, suggesting the candidate role of these molecules as tumor progression modulators rather than regulatory molecules of differentiation in lipogenic tumors." @default.
- W2114414114 created "2016-06-24" @default.
- W2114414114 creator A5032143524 @default.
- W2114414114 creator A5039802660 @default.
- W2114414114 creator A5048658487 @default.
- W2114414114 creator A5061154739 @default.
- W2114414114 creator A5066873100 @default.
- W2114414114 creator A5073515868 @default.
- W2114414114 creator A5079623922 @default.
- W2114414114 date "2010-02-03" @default.
- W2114414114 modified "2023-10-14" @default.
- W2114414114 title "Significance of LRP and PPAR-γ Expression in Lipomatous Soft Tissue Tumors" @default.
- W2114414114 cites W1559792721 @default.
- W2114414114 cites W1586597239 @default.
- W2114414114 cites W1600759390 @default.
- W2114414114 cites W1604729942 @default.
- W2114414114 cites W1820449832 @default.
- W2114414114 cites W1896807099 @default.
- W2114414114 cites W1925149569 @default.
- W2114414114 cites W19522397 @default.
- W2114414114 cites W1963900745 @default.
- W2114414114 cites W1967398770 @default.
- W2114414114 cites W1975160900 @default.
- W2114414114 cites W1975884121 @default.
- W2114414114 cites W1975927677 @default.
- W2114414114 cites W1982244552 @default.
- W2114414114 cites W1993342645 @default.
- W2114414114 cites W2029501542 @default.
- W2114414114 cites W2040829463 @default.
- W2114414114 cites W2046604129 @default.
- W2114414114 cites W2050352100 @default.
- W2114414114 cites W2054154194 @default.
- W2114414114 cites W2065430193 @default.
- W2114414114 cites W2070984749 @default.
- W2114414114 cites W2080174127 @default.
- W2114414114 cites W2091321756 @default.
- W2114414114 cites W2117938858 @default.
- W2114414114 cites W2118488782 @default.
- W2114414114 cites W2127192086 @default.
- W2114414114 cites W2141553512 @default.
- W2114414114 cites W2143975632 @default.
- W2114414114 cites W2145965997 @default.
- W2114414114 cites W2146597835 @default.
- W2114414114 cites W2149883884 @default.
- W2114414114 cites W2161276143 @default.
- W2114414114 cites W2169889638 @default.
- W2114414114 cites W2182240147 @default.
- W2114414114 cites W2462235201 @default.
- W2114414114 cites W4248025115 @default.
- W2114414114 doi "https://doi.org/10.2174/1874325001004010048" @default.
- W2114414114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2835867" @default.
- W2114414114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20224740" @default.
- W2114414114 hasPublicationYear "2010" @default.
- W2114414114 type Work @default.
- W2114414114 sameAs 2114414114 @default.
- W2114414114 citedByCount "3" @default.
- W2114414114 countsByYear W21144141142013 @default.
- W2114414114 countsByYear W21144141142016 @default.
- W2114414114 crossrefType "journal-article" @default.
- W2114414114 hasAuthorship W2114414114A5032143524 @default.
- W2114414114 hasAuthorship W2114414114A5039802660 @default.
- W2114414114 hasAuthorship W2114414114A5048658487 @default.
- W2114414114 hasAuthorship W2114414114A5061154739 @default.
- W2114414114 hasAuthorship W2114414114A5066873100 @default.
- W2114414114 hasAuthorship W2114414114A5073515868 @default.
- W2114414114 hasAuthorship W2114414114A5079623922 @default.
- W2114414114 hasBestOaLocation W21144141141 @default.
- W2114414114 hasConcept C121608353 @default.
- W2114414114 hasConcept C126322002 @default.
- W2114414114 hasConcept C142724271 @default.
- W2114414114 hasConcept C170493617 @default.
- W2114414114 hasConcept C187345961 @default.
- W2114414114 hasConcept C204232928 @default.
- W2114414114 hasConcept C2776730994 @default.
- W2114414114 hasConcept C2778256501 @default.
- W2114414114 hasConcept C2779568860 @default.
- W2114414114 hasConcept C2781225692 @default.
- W2114414114 hasConcept C502942594 @default.
- W2114414114 hasConcept C555283112 @default.
- W2114414114 hasConcept C71924100 @default.
- W2114414114 hasConceptScore W2114414114C121608353 @default.
- W2114414114 hasConceptScore W2114414114C126322002 @default.
- W2114414114 hasConceptScore W2114414114C142724271 @default.
- W2114414114 hasConceptScore W2114414114C170493617 @default.
- W2114414114 hasConceptScore W2114414114C187345961 @default.
- W2114414114 hasConceptScore W2114414114C204232928 @default.
- W2114414114 hasConceptScore W2114414114C2776730994 @default.
- W2114414114 hasConceptScore W2114414114C2778256501 @default.
- W2114414114 hasConceptScore W2114414114C2779568860 @default.
- W2114414114 hasConceptScore W2114414114C2781225692 @default.
- W2114414114 hasConceptScore W2114414114C502942594 @default.
- W2114414114 hasConceptScore W2114414114C555283112 @default.
- W2114414114 hasConceptScore W2114414114C71924100 @default.
- W2114414114 hasIssue "1" @default.
- W2114414114 hasLocation W21144141141 @default.
- W2114414114 hasLocation W21144141142 @default.
- W2114414114 hasLocation W21144141143 @default.
- W2114414114 hasLocation W21144141144 @default.