FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114429672> ?p ?o ?g. }

• W2114429672 endingPage "827" @default.
• W2114429672 startingPage "823" @default.
• W2114429672 abstract "Stroke trials often analyze patients with heterogeneous prognoses using a single definition of outcome, which may not be applicable to all subgroups. We aimed to evaluate the treatment effects of MCL601 among patients stratified by prognosis in the Chinese Medicine Neuroaid Efficacy on Stroke Recovery (CHIMES) study.Analyses were performed using data from the CHIMES study, an international, randomized, placebo-controlled, double-blind trial comparing MLC601 with placebo in patients with ischemic stroke of intermediate severity in the preceding 72 hours. All subjects with baseline data and the modified Rankin Scale (mRS) score at 3 months were included.Data from 1006 subjects were analyzed. The predictive variables for mRS score greater than 1 at month 3 were age older than 60 years (P < .001), baseline National Institutes of Health Stroke Scale score 10-14 (P < .001), stroke onset to initiation of study treatment of more than 48 hours (P < .001), and female sex (P = .026). A higher number of predictors was associated with poorer mRS score at month 3 for both placebo (P < .001) and treatment (P < .001) groups. The odds ratio (OR) for achieving a good outcome increased with the number of predictors and reached statistical significance in favor of MLC601 among patients with 2 to 4 predictors combined (unadjusted OR = 1.44, 95% confidence interval, 1.02-2.03; adjusted OR = 1.60, 95% confidence interval, 1.10-2.34).Age, sex, baseline National Institutes of Health Stroke Scale score, and time to first dose are predictors of functional outcome in the CHIMES study. Stratification by prognosis showed that patients with 2 or more predictors of poorer outcome have better treatment effect with MLC601 than patients with single or no prognostic factor. These results have implications on designing future stroke trials." @default.
• W2114429672 created "2016-06-24" @default.
• W2114429672 creator A5008989080 @default.
• W2114429672 creator A5009523088 @default.
• W2114429672 creator A5020503013 @default.
• W2114429672 creator A5022789521 @default.
• W2114429672 creator A5024061954 @default.
• W2114429672 creator A5034374147 @default.
• W2114429672 creator A5038328686 @default.
• W2114429672 creator A5057300628 @default.
• W2114429672 creator A5060145640 @default.
• W2114429672 creator A5062096569 @default.
• W2114429672 creator A5064634288 @default.
• W2114429672 date "2015-04-01" @default.
• W2114429672 modified "2023-10-01" @default.
• W2114429672 title "Prognostic Factors and Treatment Effect in the CHIMES Study" @default.
• W2114429672 cites W148053018 @default.
• W2114429672 cites W1521155577 @default.
• W2114429672 cites W1597830591 @default.
• W2114429672 cites W1936428049 @default.
• W2114429672 cites W1989883289 @default.
• W2114429672 cites W2006667907 @default.
• W2114429672 cites W2016997908 @default.
• W2114429672 cites W2026726977 @default.
• W2114429672 cites W2053979603 @default.
• W2114429672 cites W2055866433 @default.
• W2114429672 cites W2066919448 @default.
• W2114429672 cites W2071445982 @default.
• W2114429672 cites W2074858975 @default.
• W2114429672 cites W2078120261 @default.
• W2114429672 cites W2112161237 @default.
• W2114429672 cites W2118660285 @default.
• W2114429672 cites W2142640478 @default.
• W2114429672 cites W2148207944 @default.
• W2114429672 cites W2153237761 @default.
• W2114429672 cites W2159186412 @default.
• W2114429672 cites W2159515166 @default.
• W2114429672 cites W2161864397 @default.
• W2114429672 cites W2163915075 @default.
• W2114429672 cites W2529787649 @default.
• W2114429672 cites W4235543847 @default.
• W2114429672 cites W2147466032 @default.
• W2114429672 doi "https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.11.017" @default.
• W2114429672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25680658" @default.
• W2114429672 hasPublicationYear "2015" @default.
• W2114429672 type Work @default.
• W2114429672 sameAs 2114429672 @default.
• W2114429672 citedByCount "15" @default.
• W2114429672 countsByYear W21144296722015 @default.
• W2114429672 countsByYear W21144296722016 @default.
• W2114429672 countsByYear W21144296722018 @default.
• W2114429672 countsByYear W21144296722020 @default.
• W2114429672 countsByYear W21144296722022 @default.
• W2114429672 countsByYear W21144296722023 @default.
• W2114429672 crossrefType "journal-article" @default.
• W2114429672 hasAuthorship W2114429672A5008989080 @default.
• W2114429672 hasAuthorship W2114429672A5009523088 @default.
• W2114429672 hasAuthorship W2114429672A5020503013 @default.
• W2114429672 hasAuthorship W2114429672A5022789521 @default.
• W2114429672 hasAuthorship W2114429672A5024061954 @default.
• W2114429672 hasAuthorship W2114429672A5034374147 @default.
• W2114429672 hasAuthorship W2114429672A5038328686 @default.
• W2114429672 hasAuthorship W2114429672A5057300628 @default.
• W2114429672 hasAuthorship W2114429672A5060145640 @default.
• W2114429672 hasAuthorship W2114429672A5062096569 @default.
• W2114429672 hasAuthorship W2114429672A5064634288 @default.
• W2114429672 hasBestOaLocation W21144296721 @default.
• W2114429672 hasConcept C126322002 @default.
• W2114429672 hasConcept C127413603 @default.
• W2114429672 hasConcept C142724271 @default.
• W2114429672 hasConcept C156957248 @default.
• W2114429672 hasConcept C168563851 @default.
• W2114429672 hasConcept C1862650 @default.
• W2114429672 hasConcept C204787440 @default.
• W2114429672 hasConcept C27081682 @default.
• W2114429672 hasConcept C2780645631 @default.
• W2114429672 hasConcept C2780931571 @default.
• W2114429672 hasConcept C3020199598 @default.
• W2114429672 hasConcept C44249647 @default.
• W2114429672 hasConcept C541997718 @default.
• W2114429672 hasConcept C71924100 @default.
• W2114429672 hasConcept C78519656 @default.
• W2114429672 hasConceptScore W2114429672C126322002 @default.
• W2114429672 hasConceptScore W2114429672C127413603 @default.
• W2114429672 hasConceptScore W2114429672C142724271 @default.
• W2114429672 hasConceptScore W2114429672C156957248 @default.
• W2114429672 hasConceptScore W2114429672C168563851 @default.
• W2114429672 hasConceptScore W2114429672C1862650 @default.
• W2114429672 hasConceptScore W2114429672C204787440 @default.
• W2114429672 hasConceptScore W2114429672C27081682 @default.
• W2114429672 hasConceptScore W2114429672C2780645631 @default.
• W2114429672 hasConceptScore W2114429672C2780931571 @default.
• W2114429672 hasConceptScore W2114429672C3020199598 @default.
• W2114429672 hasConceptScore W2114429672C44249647 @default.
• W2114429672 hasConceptScore W2114429672C541997718 @default.
• W2114429672 hasConceptScore W2114429672C71924100 @default.
• W2114429672 hasConceptScore W2114429672C78519656 @default.
• W2114429672 hasIssue "4" @default.

• next